Pending approval, CAM2038 may be the first long-acting treatment for OUD in both weekly and monthly formulations.

Duration of preoperative opioid use was the demographic and clinical factors that most predicted continued opioid use following a surgical procedure.

Gottlieb said "The charge to this new task force is to look for holistic solutions to addressing the underlying causes for these [drug] shortages."

Women prescribed long- vs short-term opioids for chronic musculoskeletal pain may be at increased risk for menopause and abnormal menstruation.

Of 81 samples of kratom collected for testing, 42 (52%) were contaminated with Salmonella, indicating that a high proportion of kratom being shipped into the United States may be contaminated.

In their article, the authors report on two patients who used kratom to self-treat their chronic pain after they could no longer receive opioid analgesics from healthcare providers.

Although the huge death toll from opioids needs to be reduced, physicians are concerned about how to provide adequate chronic pain management for patients.

Remoxy ER contains oxycodone, a full opioid agonist, and utilizes the Company's ORADUR technology which is designed to deter abuse via non-oral routes.

Overall, 11.1% of buprenorphine exposures were for adolescents; 77.1% of these were intentional, including 12% involving suspected suicide, and multiple substances were involved in 27.7%.

The highest risk of overdose was seen on the first days of concurrent opioid and benzodiazepine use, with a decrease in risk over time.

Through their predictive analytics, Cigna can identify customers most likely to suffer from an overdose and can prompt interventions.

Pain management could be enhanced by research to develop a better understanding of chronic pain and development of new non-addictive pain treatments. To speed movement of non-addictive treatments through the clinical pipeline, a public-private HEAL partnership is planned.

Minority of opioid overdose survivors receive MOUD; buprenorphine, MMT linked to reduced mortality

The treatment combines buprenorphine, a partial-opioid agonist, with naloxone, an opioid antagonist.

The effects of the US Drug Enforcement Administration's 2014 ruling to reschedule hydrocodone combination products on the trade in opioids through cryptomarkets was analyzed by researchers.

The researchers found that being age 65 years or older (40.9 versus 29.5%; P=.026), being in an ICU (medical ICU/cardiac ICU: 27.3 versus 3.4%; P<.001; surgical ICU: 18.1 versus 5.7%; P=.031), and having renal impairment (estimated glomerular filtration rate ≤60: 50 vs 28.4%; P=.034) were associated with opioid overdose.

Electrical pulses are sent through small needles that are inserted in the ear to combat the early stages of detoxification, leading to stabilization.

Researchers assessed factors associated with post-discharge persistent opioid use of up to 6 months in a group of 86 children and adolescents (median age, 12 years) who had undergone cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.

The U.S. Food and Drug Administration has issued warnings to 9 online companies selling illegal opioid medications on 53 websites, in direct violation of the Federal Food, Drug, and Cosmetic Act.

The researchers found that 168,315,458 patients filled IR formulations and 10,216,570 filled extended-release/long-acting (ER/LA) formulations.

NKTR-181 is a long-acting selective full mu-opioid agonist.

Impact of medications on mother-infant dyad should be considered, as many women breastfeed

There was a positive correlation for subsequent opioid overdose with successively greater numbers of prescribers or pharmacies or higher opioid quantities during the index period.

In this multicenter, double-blind, placebo-controlled trial, patients (N=409) were randomized 1:1:1 to a postoperative regimen of IV tramadol 50mg, IV tramadol 25mg, or placebo administered over 15 minutes at hours 0, 2, 4, and once every 4 hours thereafter (up to 13 doses).

The highest percentage of unused medications (70%) was seen for cystectomy, which was the most invasive surgery; the lowest percentage of unused medications was seen for cystoscopy-based procedures (37.5%).