Narcotic Analgesics

FDA to Review Long-Acting Treatment for Opioid Use Disorder

By July 16, 2018

Pending approval, CAM2038 may be the first long-acting treatment for OUD in both weekly and monthly formulations.

Most Back Pain Patients Halt Opioid Use After Surgery

July 13, 2018

Duration of preoperative opioid use was the demographic and clinical factors that most predicted continued opioid use following a surgical procedure.

FDA Announces New Drug Shortages Task Force

By July 12, 2018

Gottlieb said "The charge to this new task force is to look for holistic solutions to addressing the underlying causes for these [drug] shortages."

Reproductive Dysfunction Risk in Women Taking Long-Term Pain Meds

July 10, 2018

Women prescribed long- vs short-term opioids for chronic musculoskeletal pain may be at increased risk for menopause and abnormal menstruation.

High Rates of <i>Salmonella</i> Contamination ID'd in Kratom

July 10, 2018

Of 81 samples of kratom collected for testing, 42 (52%) were contaminated with Salmonella, indicating that a high proportion of kratom being shipped into the United States may be contaminated.

Case Report Details Use of Buprenorphine for Treatment of Kratom Dependence

By July 06, 2018

In their article, the authors report on two patients who used kratom to self-treat their chronic pain after they could no longer receive opioid analgesics from healthcare providers.

New Rules May Constrain Docs' Ability to Treat Chronic Pain

June 29, 2018

Although the huge death toll from opioids needs to be reduced, physicians are concerned about how to provide adequate chronic pain management for patients.

FDA Committees Vote on Remoxy ER for Severe Pain Management

By June 27, 2018

Remoxy ER contains oxycodone, a full opioid agonist, and utilizes the Company's ORADUR technology which is designed to deter abuse via non-oral routes.

Nearly Half of All Pediatric Buprenorphine Exposures Result in Hospitalization

June 25, 2018

The majority of buprenorphine exposures in children 19 years and younger reported to the National Poison Data System (NPDS) were among children 6 years old and unintentional. However, the majority of exposures among adolescents aged 13 to 19 years were intentional and more commonly involved multiple substances.

Poison Control Center Data Detail Peds Exposure to Buprenorphine

June 25, 2018

Overall, 11.1% of buprenorphine exposures were for adolescents; 77.1% of these were intentional, including 12% involving suspected suicide, and multiple substances were involved in 27.7%.

Risk of OD Highest for First Days of Opioid &#43; Benzodiazepine Use

June 25, 2018

The highest risk of overdose was seen on the first days of concurrent opioid and benzodiazepine use, with a decrease in risk over time.

Insurance Company Sets Goal for Reducing Opioid Overdoses by 25%

By June 22, 2018

Through their predictive analytics, Cigna can identify customers most likely to suffer from an overdose and can prompt interventions.

NIH Initiative Aims to Address Opioid Misuse Over Long Term

June 21, 2018

Pain management could be enhanced by research to develop a better understanding of chronic pain and development of new non-addictive pain treatments. To speed movement of non-addictive treatments through the clinical pipeline, a public-private HEAL partnership is planned.

Meds for Opioid Use Disorder May Reduce Mortality in OD Survivors

June 20, 2018

Minority of opioid overdose survivors receive MOUD; buprenorphine, MMT linked to reduced mortality

First Generic Versions of Suboxone Get FDA Approval for Opioid Dependence

By June 15, 2018

The treatment combines buprenorphine, a partial-opioid agonist, with naloxone, an opioid antagonist.

Illicit Opioid Trade Up With Restrictions on Hydrocodone

June 14, 2018

The effects of the US Drug Enforcement Administration's 2014 ruling to reschedule hydrocodone combination products on the trade in opioids through cryptomarkets was analyzed by researchers.

Older Age, ICU, Poor Renal Fcn Up Risk of Opioid OD in Hospital

June 13, 2018

The researchers found that being age 65 years or older (40.9 versus 29.5%; P=.026), being in an ICU (medical ICU/cardiac ICU: 27.3 versus 3.4%; P<.001; surgical ICU: 18.1 versus 5.7%; P=.031), and having renal impairment (estimated glomerular filtration rate ≤60: 50 vs 28.4%; P=.034) were associated with opioid overdose.

Wearable Device Cleared for Use During Opioid Detoxification

By June 12, 2018

Electrical pulses are sent through small needles that are inserted in the ear to combat the early stages of detoxification, leading to stabilization.

Factors ID'd for Persistent Opioid Use After Pediatric Surgery

June 07, 2018

Researchers assessed factors associated with post-discharge persistent opioid use of up to 6 months in a group of 86 children and adolescents (median age, 12 years) who had undergone cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.

FDA Issue Warnings to 9 Online Sellers of Illegal Opioids

June 06, 2018

The U.S. Food and Drug Administration has issued warnings to 9 online companies selling illegal opioid medications on 53 websites, in direct violation of the Federal Food, Drug, and Cosmetic Act.

Studies ID Impact of US Opioid-Related Mortality, Rx Patterns

June 04, 2018

The researchers found that 168,315,458 patients filled IR formulations and 10,216,570 filled extended-release/long-acting (ER/LA) formulations.

NDA for First-of-Its-Kind Opioid Analgesic Submitted to FDA

By June 01, 2018

NKTR-181 is a long-acting selective full mu-opioid agonist.

Physicians should look for misuse patterns that lead to overdose before prescribing opioids

May 29, 2018

All opioid misuse patterns examined had a positive association with opioid overdose and death.

Recommendations for Managing Postpartum Pain Published

May 23, 2018

Impact of medications on mother-infant dyad should be considered, as many women breastfeed

Standard of practice intervention linked to reduced total and IV opioids for inpatients

May 22, 2018

A standard of practice and educational intervention aimed to reduce intravenous opioids in favor of subcutaneous route resulted in reduced frequency of intravenous opioids.

Patterns of Potential Misuse Help Assess Risk of Opioid Overdose

May 22, 2018

There was a positive correlation for subsequent opioid overdose with successively greater numbers of prescribers or pharmacies or higher opioid quantities during the index period.

IV Tramadol Significantly Reduces Post-Op Pain in Phase 3 Study

By May 21, 2018

In this multicenter, double-blind, placebo-controlled trial, patients (N=409) were randomized 1:1:1 to a postoperative regimen of IV tramadol 50mg, IV tramadol 25mg, or placebo administered over 15 minutes at hours 0, 2, 4, and once every 4 hours thereafter (up to 13 doses).

AUA: Many Have Unused Opioids After Urologic Procedures

May 21, 2018

The highest percentage of unused medications (70%) was seen for cystectomy, which was the most invasive surgery; the lowest percentage of unused medications was seen for cystoscopy-based procedures (37.5%).

First Non-Opioid Drug Approved for Managing Opioid Withdrawal Symptoms

By May 17, 2018

Lucemyra, a selective alpha 2-adrenergic receptor agonist, works by reducing the release of norepinephrine and decreasing sympathetic tone.