Oliceridine, a G-protein biased mu-opioid receptor (MOR) ligand, has a unique mechanism of action that allows for more selective pathway activation while avoiding a pathway associated with opioid-related adverse events.

Parents use unregulated cannabinoids to manage neurological disorders in children, including seizures, spasticity, and irritability in children with epilepsy, autism-spectrum disorder, and cerebral palsy.

An investigational treatment - CAM2038 (Braeburn) - currently under review for the treatment of moderate-to-severe opioid use disorder, has demonstrated a reduction in Chronic Low Back Pain (CLBP) compared to placebo in patients previously on long-term daily opioid therapy.

Five different committees submitted more than 70 proposals to help craft the bill, called the Opioid Crisis Response Act of 2018.

As part of the REMS program, drug companies with approved opioid analgesics must make training available to prescribers and provide unrestricted grants to accredited continuing education providers for the development of education courses.

The prevalences of both chronic pain and high-impact chronic pain were higher among women; older adults; adults who were previously, but not currently, employed; adults living in poverty; those with public health insurance; and rural residents.

Cassipa combines buprenorphine, an opioid (partial agonist-antagonist), and naloxone, an opioid antagonist.

But in the longer term, the majority of opioid prescriptions come from primary care physicians

The new plan will break out the current guidance into 4 separate guidances.

For patients receiving both treatments, the group receiving opioids first had mean hip-related downstream costs that were significantly higher than the group receiving physical therapy first ($18,806 versus $16,955).

Americans who buy prescription medicines such as opioids from illegal online pharmacies may be putting their health at risk because the drugs may be counterfeit, contaminated, expired, or otherwise unsafe, according to the FDA.

After expansion, there was a significant increase in buprenorphine with naloxone fills per 100,000 county residents in expansion vs non-expansion counties (8.7).

The prevalence of prenatal marijuana use was 5.3% by self-report or toxicologic test findings; prevalence was greater among females with severe and mild versus no NVP (11.3 and 8.4, respectively, vs 4.5%).

In the 6 months before the mandatory PDMP requirement, the mean number of opioid pills prescribed decreased from 30.8 to 24 (22.1%); in the 6 months after the legislation, the decrease was less, from 22.8 to 21.9 pills (3.9%).

The researchers found that the mean oral morphine equivalents (OMEs) filled in the initial opioid prescription increased by about 35 after the schedule change (β = 35.1; P<.01), which was equivalent to seven hydrocodone tablets (5mg).

Dose-response association with highest odds of opioid-related death with high-dose prefabbing

Last year, the DEA proposed a 20% reduction in the manufacturing of controlled substances for 2018 compared to 2017.

"All health care providers have a role in combating the OUD epidemic and its infectious disease consequences. Those who treat infectious complications of OUD are well-suited to screen for OUD and begin treatment with effective US Food and Drug Administration-approved medications," the authors write.

This increase mirrored the 79.7% increase in opioid overdose mortality from 7.4 (deaths per 100,000 persons) to 13.3.

Rate of opioid use disorder at time of delivery quadrupled from 1999 to 2014

Studies comparing MMT to buprenorphine maintenance treatment (BMT) over 5-years found buprenorphine to be a safer drug for opioid maintenance treatment as it had no significant effect on QT prolongation.

Lucemyra is not indicated as a treatment for opioid use disorder.

In June 2018, the FDA's Anesthetic and Analgesic Drug Products Advisory Committee and Drug Safety and Risk Management Advisory Committee met and voted against (14-3) the approval of Remoxy upon data review.

This novel agent has low permeability across the blood-brain barrier, which slows its rate of entry into the brain and reduces dopamine release.

Dental procedures, outpatient procedure and/or surgery, trauma, and infections were the most common opioid indications.