Narcotic Analgesics

Opioid Prescribing, Use Continues Even After Overdose

August 23, 2017

Of the 3,945 who had overdosed on prescription opioids, prescriptions decreased from 32.4% before the overdose to 28.3% after. Meanwhile, the number of patients receiving medication-assisted treatment rose from 29.4 to 33.0% after a heroin overdose.

Opioids Greatly Overused as Migraine Treatment, Study Finds

By August 17, 2017

For abortive medications, results showed that overall 18.9% of patients received all high quality abortive medication, 27% received some low quality abortive while 15.2% received opioids.

Is ED-Initiated Buprenorphine for Opioid Dependence Cost Effective?

By August 16, 2017

Results showed that the mean costs over the next 30 days after ED visits were $1,752, $1,805 and $1,977 for ED-initiated buprenorphine, referral alone and brief intervention with facilitated referral, respectively.

Necessity of Opioid Rx Examined Post-Hernia Repair

August 15, 2017

The researchers found that 85.9% of patients reported using four or fewer opioid tablets, with 59.5% reporting that they used no opioid analgesics postoperatively.

Cannabis Efficacy Examined in Patients with Chronic Pain, PTSD

August 15, 2017

The researchers found low-strength evidence that cannabis alleviates neuropathic pain based on 27 chronic pain trials; insufficient evidence was found in other pain populations.

Severe Rise in Opioid Overdose ICU Admissions From 2009 to 2015

August 14, 2017

There was a 34% increase in opioid overdose admissions requiring intensive care during this time period, from 44 to 59 per 10,000 ICU admissions. The average mortality rate of patients with ICU admissions with overdoses was 7%, but this increased to 10% in 2015.

Opioid Epidemic Declared National Emergency

By August 11, 2017

Among the areas likely to benefit from increased funding are treatment centers, with the White House panel recommending rules be waived so that Medicaid recipients can get treatment for their addictions.

DEA Issues Comprehensive 'Drug Slang' List to Aid in Abuse Identification

August 11, 2017

In light of the plethora of street names used to refer to a number of drugs, the DEA has issued a comprehensive list for common drugs.

Does the FDA's 'Flush List' Pose a Toxic Threat?

By August 10, 2017

The full results, published in Science of The Total Environment, found that even if the entire mass supplied for clinical use was flushed that the release of 10 'flush list' APIs poses a 'negligible' eco-toxicological risk (including buprenorphine, diazepam, fentanyl, hydromorphone, meperidine, methadone, methylphenidate, morphine, oxycodone, tapentadol).

Marijuana Use May Increase Risk of Death from Hypertension

August 10, 2017

Over 19,569 person-years of follow-up, the adjusted hazard ratios for death from hypertension among marijuana users was 3.42 (95% confidence interval, 1.20 to 9.79).

Opioid Prescribing Trends Among Cancer Survivors

August 10, 2017

Significantly higher prescribing rates were seen in individuals from lower income quintiles, who were younger, who were from rural neighborhoods, and who had a greater number of comorbidities.

Interactions Identified Between Cannabidiol, Antiepileptic Drugs

August 08, 2017

The researchers observed significant increases in topiramate, rufinamide, and N-desmethylclobazam and a significant decrease in clobazam serum levels with increasing cannabidiol dose.

DEA Proposes Cut in Controlled Substance Manufacturing for 2018

By August 04, 2017

The DEA's manufacturing reduction applies to commonly prescribed Schedule II opioids.

Study Suggests 'Reservoir' of Unused Rx Opioids in U.S.

August 04, 2017

Researchers found that between 67 and 92% of patients reported unused opioids (42 to 71% of all the opioid tablets).

Reasons for Buprenorphine Underuse ID'd in Physician Survey

August 04, 2017

The main reasons that physicians with waivers indicated no willingness to increase prescribing were lack of belief in agonist treatment (odds ratio, 3.98), lack of time for additional patients (odds ratio, 5.54), and belief that reimbursement rates are insufficient (odds ratio, 2.50).

Neonatal Drug Withdrawal Risk Up with In Utero Exposure to Opioids, Psychotropics

August 03, 2017

The researchers observed variation in the absolute risk for neonatal drug withdrawal from 1.0 to 11.4% for infants exposed in utero to prescription opioids alone and opioids co-prescribed with gabapentin, respectively.

Sefria Fentanyl Screening Test Gets FDA Clearance

By August 03, 2017

The test has demonstrated cross-reactivity with acetyl fentanyl, butyryl fentanyl, despropionyl fentanyl, and sufentanil.

Study Reports on Prevalence of Rx Opioid Use, Misuse, and Use Disorders

August 02, 2017

Nearly 92 million Americans used legitimately prescribed opioids in 2015, survey shows

Opioid Epidemic Needs to Be Declared a National Emergency, Says Special Commission

By August 01, 2017

The final recommendations - expected in the Fall - if implemented, will ensure that the Federal Government operates as a strong partner in the fight against addiction and the opioid crisis.

Morphine Effects Examined in RA, Chronic Fatigue Syndrome/Fibromyalgia

July 27, 2017

Anti-hyperalgesic effects of morphine also similar to placebo in chronic fatigue/fibromyalgia

SAMHSA Evaluate Opioid Abuse Among Over 50s in the U.S.

July 27, 2017

Rates of opioid abuse among young adults - aged 18 to 25 - decreased from 11.5% in 2002 to 8.1% in 2014. But in adults 50 years and older, opioid abuse doubled, from 1.1 to 2.0%

New Urine Test Quickly Detects Commonly Abused Rx Drugs

By July 19, 2017

The rapid detection tests consists of a self-contained collection cup and test device with auto-activated results seen in 5 minutes with no tipping of the cup.

Outcomes of Tapering Long-Term Opioid Tx Examined

July 19, 2017

The researchers found improvement in pain severity, function, and quality of life. The team said, however, that the quality of the evidence in the studies was very low.

DEA Proposes Rule to Deschedule Naldemedine

By July 18, 2017

Recently, Shionogi and Purdue received Food and Drug Administration (FDA) approval for naldemedine (Symproic) in the treatment of opioid-induced constipation in adults with chronic non-cancer pain.

What Effect Did FDA's APAP Limit Have on Liver Injury Incidence?

By July 17, 2017

Of the total 18,259 calls during the study period, 5.16% led to N-acetylcysteine administration in 2013 and 5.01% in 2015. Naloxone was administered in 3.63% and 4.02% of cases in 2013 and 2015, respectively.

Tramadol ER Looks Promising for Opioid Withdrawal Management

July 14, 2017

The data showed patients receiving buprenorphine (90.3%) were significantly more likely to be retained at the end of the taper vs. patients receiving clonidine (66.1%) but retention with tramadol ER (72.2%) was moderate and did not significantly differ from that of the other treatment arms (P=0.01).

Errors Common with Handwritten Opioid Rxs

July 14, 2017

For 42% of prescriptions there was at least 1 error. Nine percent of prescriptions deviated from best practice guidelines, 21% did not include 2 patient identifiers, and 41% were not compliant with the Drug Enforcement Agency rules.

Report Investigates Non-Medical Opioid Use State-by-State

July 14, 2017

Nonmedical opioid use was most common in Oklahoma, Alabama, Arkansas, and Nevada, all with rates exceeding 5%. The lowest rates - less than 3.5% - were in Massachusetts, Vermont, Florida, Montana, and Minnesota, the report noted.

FDA Commissioner Announces New Steps for Combating the Opioid Epidemic

July 12, 2017

The new FDA Commissioner of Food and Drugs, Dr. Scott Gottlieb, presented a list of new initiatives the Agency will undertake in order to tackle the opioid epidemic.

The Rate of At-Home Medication Errors Has Doubled

July 11, 2017

The rate of serious medication errors rose from 1.09 for every 100,000 Americans in 2000 to 2.28 per 100,000 by 2012.