Nabumetone Rx

Select the drug indication to add to your list

Nabumetone

Arthritis/rheumatic disorders
Only 4 drugs may be compared at once

Generic Name and Formulations:

Nabumetone 500mg, 750mg; tabs.

Select therapeutic use:

Indications for Nabumetone:

Rheumatoid arthritis. Osteoarthritis.

Adult:

Initially 1g once daily; max 2g/day in 1 or 2 divided doses. Renal insufficiency (CrCl 30–49mL/min): initial max 750mg once daily, may increase to 1.5g/day; (CrCl <30mL/min): initial max 500mg once daily, may increase to 1g/day.

Children:

Not recommended.

Contraindications:

Aspirin allergy. 3rd trimester pregnancy. Coronary artery bypass graft surgery.

Warnings/Precautions:

Advanced renal disease: not recommended. History of upper GI disease or other ulcer risk. Cardiovascular disease. Renal or severe hepatic impairment. Fluid retention. Heart failure. Hypertension. Asthma. Monitor BP, renal and hepatic function. Discontinue if hepatic dysfunction or skin rash occurs. Monitor hemoglobin or hematocrit if signs of anemia occur. Avoid sun, UV light. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Renal toxicity potentiated with diuretics. May potentiate lithium. May antagonize ACE inhibitors. Monitor oral anticoagulants (eg, warfarin). Caution with methotrexate.

Pharmacological Class:

NSAID (naphthylalkanone).

Adverse Reactions:

GI bleeding or upset, edema, photosensitivity, dry mouth, dizziness, headache, fatigue, sweating, insomnia, nervousness, somnolence, rash (discontinue if occurs), pruritus, tinnitus. See literature re: risk of cardiovascular events.

Note:

Formerly known under the brand name Relafen.

How Supplied:

Contact supplier