Musculoskeletal Disorders

Discontinuation Rates Examined After Switch to Biosimilar

By October 18, 2017

Study authors aimed to assess the pharmacokinetics, efficacy, immunogenicity, safety, and drug discontinuation after switching from infliximab (Remicade) to the biosimilar CT-P13 in 192 patients with rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis in daily practice.

Stelara Approved to Treat Adolescent Patients With Plaque Psoriasis

By October 16, 2017

The expanded approval was supported by data from a Phase 3 study that evaluated the safety and efficacy of subcutaneous Stelara in adolescents aged ≥12 years.

Has Mass Media Criteria for What Constitutes Beauty Evolved?

October 12, 2017

In 1990, Fitzpatrick skin types I to III represented 88% of the celebrities on the list and Fitzpatrick skin types IV to VI represented 12%; in contrast, in 2017, Fitzpatrick skin types I to III and IV to VI represented 70.4 and 29.6%, respectively

Duzallo Now Available for the Treatment of Uncontrolled Gout

By October 10, 2017

The fixed-dose product combines lesinurad, a uric acid transporter 1 (URAT1) inhibitor, with allopurinol, a xanthine oxidase inhibitor in one tablet.

Zilretta Approved to Treat Osteoarthritis Knee Pain

By October 10, 2017

Phase 3 results found that Zilretta achieved statistically significant reductions on the Western Ontario and McMaster Universities Arthritis Index (WOMAC) sections for pain, stiffness and function compared to immediate-release TCA.

CombiPatch, Minivelle Patches No Longer in Shortage

By October 03, 2017

Noven announced that CombiPatch (estradiol/norethindrone acetate transdermal system) and Minivelle (estradiol transdermal system) are now readily available following a temporary product shortage.

Uloric Dosing Updated to Include Patients with Severe Renal Impairment

By September 27, 2017

The new labeling now recommends patients with severe renal impairment be limited to a dose of 40mg once daily.

FDA: More Data Needed for Sirukumab for Active RA

By September 27, 2017

The CRL indicated a request for additional clinical data in order to evaluate the safety of sirukumab in the treatment of RA.

USPSTF Issues New Fall Prevention Recommendations

September 27, 2017

Multifactorial interventions to prevent falls should be offered selectively by clinicians; the overall net benefit of routinely offering multifactorial interventions is small.

Movement Disorder Symptoms Found to Diminish with Alcohol Intake

September 22, 2017

The researchers found that patients showed a significantly reduced number of conditioned eyeblink responses before alcohol administration versus controls.

UTI Treatment Gains Qualified Infectious Disease Product Designation

By September 21, 2017

"We expect to begin enrolling patients as early as December in a proof-of-concept Phase 2 study of omadacycline in uUTI, and an indication in this type of infection would broaden the opportunities for oral omadacycline in community-acquired infections," said Evan Loh, MD, COO and CMO of Paratek.

Efficacy of Steroid Injection Examined in Carpal Tunnel

September 21, 2017

Only the steroid group saw improvement in finger dexterity. The steroid group also had higher patient satisfaction scores and, as a group, the patients took fewer painkillers after treatment.

Long-Term Effectiveness of Adalimumab Examined in RA

By September 14, 2017

The authors reported that of the patients who continued taking adalimumab for ≥1 year, 67.0% were considered in low disease activity (LDA)/remission (CDAI ≥10).

Romosozumab Followed by Alendronate Superior in Reducing Fracture Risk

By September 12, 2017

ARCH (Active-contRolled FraCture Study in Postmenopausal Women with Osteoporosis at High Risk of Fracture) was a multicenter, international, randomized, double-blind, alendronate-controlled study (n=4,093) in postmenopausal women with osteoporosis at high risk for fracture based on previous fracture history.

Fracture Risk Reduced with Abaloparatide Followed by Alendronate

By September 11, 2017

The data showed a statistically significant fracture risk reduction through 3.5 years.

Alendronate Safe, Effective in Elderly Patients with Prior Fracture

September 07, 2017

Alendronate treatment reduced risk of hip fracture with sustained safety

Durolane Approved to Treat Knee Osteoarthritis Pain

By September 05, 2017

In clinical trials, treatment with Durolane effectively relieved pain and restored function for up to six months in patients with knee osteoarthritis.

Limiting Sedentary Time 'Necessary' to Avoid Mobility Loss

August 31, 2017

At the study's end, 29% of participants were either unable to walk or had difficulty doing so.

Increases in BP, Hypertension Incidence Linked to Certain NSAIDs

By August 28, 2017

The PRECISION-ABPM study included 444 patients (408 with osteoarthritis; 36 RA) who had evidence of, or were at increased risk for, coronary artery disease.

FDA Reveals Stem Cell Policy Plans Amid Clinic Crackdowns

By August 28, 2017

An FDA inspection of the clinic found that adipose tissue was being processed into stromal vascular fraction (stem cells derived from body fat) which was then administered intravenously or directly into the spinal cord of patients.

Biosimilar Cyltezo Gets FDA Approval for Multiple Indications

By August 28, 2017

This marks the second approval of a biosimilar for adalimumab.

Fixed-Dose Combo Tx Duzallo Approved for Uncontrolled Gout

By August 21, 2017

This fixed-dose combination product combines lesinurad, a uric acid transporter 1 (URAT1) inhibitor, with allopurinol, a xanthine oxidase inhibitor in one tablet.

Oral Contraceptives May Reduce Rheumatoid Arthritis Risk

August 21, 2017

The researchers found that ever and past OC users had a reduced risk of anticitrullinated protein antibodies (ACPA)-positive RA compared with never users.

Psoriatic Arthritis Treatment Trends Investigated

By August 15, 2017

Researchers used claims data between 2004-2015 from a large commercial database to identify patients with psoriatic arthritis who were initiated on DMARDs.

Are OTC Lidocaine Patches as Effective as Rx for Localized Pain?

By August 15, 2017

Study authors sought to compare OTC lidocaine 3.6% with menthol 1.25% patches vs. Rx lidocaine 5% as well as to placebo.

Necessity of Opioid Rx Examined Post-Hernia Repair

August 15, 2017

The researchers found that 85.9% of patients reported using four or fewer opioid tablets, with 59.5% reporting that they used no opioid analgesics postoperatively.

Certain Occupations May Increase the Risk for Rheumatoid Arthritis

August 11, 2017

Assistant nurses and attendants had a moderately increased risk of ACPA+ RA among women (odds ratio, 1.3; 95% CI, 1.1 to 1.6), while no occupations correlated significantly with ACPA− RA.

Osteoporosis Drugs Assessed for Secondary Fracture Prevention

By August 10, 2017

Results showed a significant reduction in the risk for secondary vertebral fracture with all of the of anti-osteoporotic drugs (risk ratio [RR] 0.38-0.77).

Arthritis Treatments: DMARDS and Other Immune Modulators

August 10, 2017

A comparative list of treatment options for arthritis including DMARDS and other immune modulators.

Osteoporosis Med Efficacy Assessed in Nonmetastatic Prostate CA

August 09, 2017

The researchers found that BMD was effectively increased with bisphosphonates, but no trial was sufficiently powered to detect a decrease in fractures.