Musculoskeletal Disorders

RA Treatment During Pregnancy: Is Infection Risk Greater in Offspring?

By May 18, 2018

Offspring were followed from birth until 12 months, first indication of serious infection, end of commercial insurance eligibility, death or end of study period, whichever came first.

Adding Chiropractic to Usual Care Beneficial for Low Back Pain

May 18, 2018

"This trial provides additional support for the inclusion of chiropractic care as a component of multidisciplinary health care for low back pain, as currently recommended in existing guidelines," the authors write.

Certolizumab Pegol Beneficial in Non-Radiographic Axial Spondyloarthritis

By May 17, 2018

During the 52-week trial period, the treatment group received a 400mg dose of CZP subcutaneously at weeks 0, 2, and 4, followed by 200mg of CZP every 2 weeks starting at week 6; or placebo.

Actemra SC Approved to Treat Rare Form of Juvenile Arthritis

By May 14, 2018

Approval of the SC formulation for this patient population was supported by data from the Phase 1b JIGSAW-117 trial, a 52-week, open-label multicenter, pharmacokinetic/pharmacodynamic bridging study (N=52) that aimed to determine the appropriate dosing regimen of Actemra SC based on body weight in children with PJIA.

Corticosteroid-Related Adverse Events Examined Based on Dose, Duration

By May 14, 2018

Using a privately-insured administrative database, researchers examined a total of 78,704 patients with autoimmune or inflammatory disease diagnoses between 2006 and 2015.

Anxiety Levels Tied to Bone Mineral Density Post-Menopause

May 14, 2018

There was a significant correlation for anxiety levels with age, menopausal age, years since menopause, and depressive symptoms; multiple regression analysis predicted reduced BMD in the lumbar spine.

Adverse Effect of Osteoporosis Drug May Help Treat Hair Loss

By May 11, 2018

Researchers found that a non-immunosuppressant drug originally designed to treat osteoporosis (WAY-316606) targeted the same mechanism by antagonizing SFRP1, and after treating hair follicles with WAY-316606 for 6 days, the authors found enhanced human hair growth.

Osteoporosis Drug Shows Cardioprotective Potential at 10-Year Follow-Up

By May 11, 2018

The 1-year cardiovascular mortality hazard ratio (HR) for alendronate users was 0.33 (95% CI, 0.17 to 0.65) and 0.55 for incident myocardial infarction (95% CI, 0.34 to 0.89).

Vertebroplasty Does Not Up Pain Relief in Osteoporotic Fracture

May 10, 2018

"Percutaneous vertebroplasty did not result in statistically significantly greater pain relief than a sham procedure during 12 months' follow-up among patients with acute osteoporotic vertebral compression fractures," the authors write.

Provider Counseling for Weight Loss Up for Arthritis, Overweight

May 08, 2018

From 2002 to 2014, 10.4 percent increase in estimates of provider counseling for weight loss

Pharmacists Can Play Role in Identifying Frailty

May 07, 2018

Community pharmacists can identify certain risk factors for frailty, including gender, low socioeconomic status, chronic illnesses, neuroendocrine dysfunctions, and certain medications and medication regimens.

HBV Reactivation Examined in Patients Treated With TNF Antagonists

By May 03, 2018

The authors examined data from 8887 individuals who began TNF antagonist treatment for an autoimmune disease from 2001 through 2010 and were followed through 2012; 52% of these patients were screened for HBV before treatment.

Lightning Can Affect Deep Brain Stimulation Devices

May 03, 2018

Case report of 66-year-old woman whose implantable pulse generator switched off after lightning strike

Facioscapulohumeral Muscular Dystrophy Treatment Gets Fast Track Status

By May 02, 2018

ACE-083 is currently being studied in a Phase 2 trial for FSHD and another for Charcot-Marie-Tooth (CMT) disease.

Severe Obesity Tied to Faster Progression to Disability With RA

May 01, 2018

The researchers found that at baseline, severely obese patients had higher disability scores versus overweight patients in both Forward and VARA.

First FDA-Approved Treatment for X-Linked Hypophosphatemia Launched

By April 30, 2018

Crysvita, a recombinant fully human monoclonal IgG1 antibody, works by blocking fibroblast growth factor 23 (FGF23), a hormone that causes phosphate urinary excretion and suppresses vitamin D production by the kidney.

Zilretta Benefits 'Real-World' Patients With Knee OA, Says Study

By April 26, 2018

Patients who received a repeat Zilretta injection experienced a 64% improvement in Western Ontario and McMaster Universities Arthritis Index (WOMAC)-A (pain), a 66% improvement in WOMAC-B (stiffness), a 64% improvement on WOMAC-C (function), and improvement represented by a doubling of the KOOS Quality of Life subscale score by Week 4.

FDA Advisory Committee Votes on Novel RA Treatment Baricitinib

By April 24, 2018

The panel's decision was based on four Phase 3 studies which evaluated the impact of baricitinib on RA signs and symptoms, physical function, joint damage progression and other patient-reported outcomes.

One in Four Adults Report Having Arthritis

April 24, 2018

The researchers found that the age-adjusted prevalence of arthritis was 24.7% (OA, 9.7%; RA, 4.2%; other arthritis, 2.8%). Over the study period the prevalence of OA increased from 6.6 to 14.3%, while RA prevalence decreased from 5.9 to 3.8%.

Neuromodulation Therapy Gives Relief From Hand Tremor

April 20, 2018

"Our research suggests that this non-invasive therapy may offer meaningful relief from the symptoms of hand tremor for people with essential tremor," Pahwa said in a statement.

GI Safety Compared for NSAIDs in Patients With Arthritis

By April 19, 2018

The randomized, double-blind, controlled trial (N=24,081) included patients with rheumatoid arthritis or osteoarthritis who required chronic NSAID treatment.

Less Pain Post TKA With Addition of Peripheral Nerve Blocks

April 19, 2018

The researchers found that intervention patients reported lower numeric rating scale pain scores on ambulation than the control group on postoperative day (POD) one (1.7 versus 5.0; P <.001).

New Drug May Help Infants With Spinal Muscular Atrophy

April 19, 2018

The researchers identified a dose-dependent increase in SMN protein levels in blood; compared with baseline, there was up to a 6.5-fold increase after 4 weeks of treatment at the highest dose of RG7916 (range, 2.0 to 6.5).

Certain RA Treatments Tied to Improvements in Blood Pressure

By April 18, 2018

For this study, researchers used the Veterans Affairs electronic medical record databases to identify unique dispensing of methotrexate, leflunomide, sulfasalazine, hydroxychloroquine, tumor necrosis factor inhibitors, and prednisone in order to assess the effect of these treatments on systolic and diastolic blood pressure (SBP and DBP), as well as incident hypertension among RA patients.

FDA-Approved App Allows Clinicians to Objectively Measure Balance

By April 18, 2018

The application assesses 3 key balance metrics: (1) double stance, (2) right tandem stance, and (3) left tandem stance.

Young Adults With T1DM Show Muscle Metabolic Deficiencies

April 18, 2018

Participants with type 1 diabetes had an increase in the size and number of autophagic remnants in muscles; however, levels of the autophagic regulatory protein, phosphorylated AMP-activated protein kinase, and its downstream targets were similar between groups.

USPSTF: Exercise Interventions Prevent Falls in Seniors

April 18, 2018

The harms of exercise and multifactorial interventions was found to be no greater than small. Based on these findings, the USPSFT recommends exercise interventions to prevent falls among those at increased fall risk (B recommendation).

Crysvita Approved for the Treatment of X-Linked Hypophosphatemia

By April 17, 2018

Crysvita is an antibody that blocks fibroblast growth factor 23 (FGF23), a hormone that causes phosphate urinary excretion and suppresses active vitamin D production by the kidney.

Neuroscience Education, Motor Control Training Ease Spinal Pain

April 17, 2018

The researchers found that reduced pain, higher pressure pain thresholds at primary test site at 3 months, and reduced central sensitization inventory scores at 6 and 12 months were experienced by participants in the experimental group.

Untrimmed Toenails: A Marker of Functional Status in Older Patients?

By April 13, 2018

For older patients, toenail length can provide important insight into a patient's functional status.