Musculoskeletal Disorders

Psoriatic Arthritis Treatment Trends Investigated

By August 15, 2017

Researchers used claims data between 2004-2015 from a large commercial database to identify patients with psoriatic arthritis who were initiated on DMARDs.

Are OTC Lidocaine Patches as Effective as Rx for Localized Pain?

By August 15, 2017

Study authors sought to compare OTC lidocaine 3.6% with menthol 1.25% patches vs. Rx lidocaine 5% as well as to placebo.

Necessity of Opioid Rx Examined Post-Hernia Repair

August 15, 2017

The researchers found that 85.9% of patients reported using four or fewer opioid tablets, with 59.5% reporting that they used no opioid analgesics postoperatively.

Certain Occupations May Increase the Risk for Rheumatoid Arthritis

August 11, 2017

Assistant nurses and attendants had a moderately increased risk of ACPA+ RA among women (odds ratio, 1.3; 95% CI, 1.1 to 1.6), while no occupations correlated significantly with ACPA− RA.

Osteoporosis Drugs Assessed for Secondary Fracture Prevention

By August 10, 2017

Results showed a significant reduction in the risk for secondary vertebral fracture with all of the of anti-osteoporotic drugs (risk ratio [RR] 0.38-0.77).

Arthritis Treatments: DMARDS and Other Immune Modulators

August 10, 2017

A comparative list of treatment options for arthritis including DMARDS and other immune modulators.

Osteoporosis Med Efficacy Assessed in Nonmetastatic Prostate CA

August 09, 2017

The researchers found that BMD was effectively increased with bisphosphonates, but no trial was sufficiently powered to detect a decrease in fractures.

Vitamin B Effects on Fracture Risk Examined in Women at High CVD Risk

August 07, 2017

The researchers found that B vitamin supplementation had no significant effect on non-spine fracture risk (relative hazard, 1.08; 95% confidence interval, 0.88 to 1.34).

FDA Panel Recommends Approval of Tofacitinib for Psoriatic Arthritis

By August 04, 2017

The supplemental New Drug Applications (sNDAs) contained data from Phase 3 trials involving patients with psoriatic arthritis, including safety analyses from the larger tofacitinib clinical development program.

FDA Clears Non-Invasive Device to Treat Chronic Intractable Pain

By August 03, 2017

The Stimpod NMS460 includes a nerve-mapping pen-like probe which allows practitioners to locate nerves and evaluate the treatment progress.

FDA Committee Votes Against RA Drug Candidate Approval

By August 03, 2017

Sirukumab, a human monoclonal IgG1 kappa antibody, works differently than current IL-6 inhibitors approved to treat RA by targeting the IL-6 cytokine vs. the IL-6 receptor.

Xatmep Now Available for Pediatric ALL, pJIA

By July 31, 2017

Methotrexate works by inhibiting dihydrofolic acid reductase, which interferes with DNA synthesis, repair, and cellular replication.

Mislabeled Muscle Spasm, Parkinson's Drugs Prompt Recall

By July 28, 2017

Accidental dosing with Cyclobenzaprine HCl may potentially lead to life-threatening serotonin syndrome when the drug is taken in combination with selective serotonin reuptake inhibitors.

Muscle Spasm Treatments

July 28, 2017

Muscle spasm treatment chart with dosing regimens for muscle relaxants and other medications.

Septic Arthritis Outbreak Highlights Need for Better Infection Prevention in Outpatient Settings

By July 27, 2017

Recovered organisms included various Streptococcus, Actinomyces, Haemophilus, Neisseria species, among others; all of the pathogens isolated were oral flora. Two patients also exhibited Staphylococcus aureus bacteria in the blood.

Morphine Effects Examined in RA, Chronic Fatigue Syndrome/Fibromyalgia

July 27, 2017

Anti-hyperalgesic effects of morphine also similar to placebo in chronic fatigue/fibromyalgia

Biosimilar Renflexis Now Available

July 24, 2017

Infliximab products work by neutralizing the biological activity of TNF-alpha by binding with high affinity to the soluble and transmembrane forms of TNF-alpha and inhibiting the binding of TNF-alpha with its receptors.

FDA Requests More Data for Unique Osteoporosis Drug Candidate

By July 17, 2017

Dr. Pascale Richetta, head of bone and executive vice president, UCB, stated, "With all three pivotal romosozumab Phase 3 studies now included in the clinical evidence package, representing data from more than 11,000 patients, we are committed to bringing this important potential new treatment to those people living at risk of fragility fractures."

Octagam 10% Gains Orphan Drug Status for Rare Muscle, Skin Disorder

July 17, 2017

Octagam 10% is currently approved to treat chronic immune thrombocytopenic purpura (ITP) in adult patients. It is supplied as 2g, 5g, 10g, or 20g single-use bottles.

Research Paper Reviews JFK's Chronic Health Issues

By July 14, 2017

A new review published in the Journal of Neurosurgery: Spine details the health issues that troubled JFK the most, specifically his back. His low-back pain was instigated by a football injury sustained while he was at Harvard in 1937. An orthopedic spine specialist diagnosed him in 1940 with a "very unstable lumbosacral joint".

Alendronate May Lower Hip Fracture Risk for Patients on Oral Glucocorticoids

By July 13, 2017

Results showed that after a mean follow-up of 1.32 years, there were 27 hip fractures in the alendronate group and 73 in the non-alendronate group; this corresponded to incident rates of 9.5 (95% CI, 6.5-13.9) and 27.2 (95% CI, 21.6-34.2) fractures per 1000 person-years, respectively.

Shock Wave Therapy Assessed for Efficacy in Arthritis, Arthralgia

July 10, 2017

"To our knowledge, this is the first report using this therapy to treat arthralgia in rheumatoid arthritis," the authors write.

Orencia Approved to Treat Active Psoriatic Arthritis

By July 06, 2017

A greater response to Orencia was observed in the trial regardless of prior anti-TNF treatment and other non-biologic DMARD therapy.

Is Radiofrequency Denervation Effective for Chronic Low Back Pain?

By July 05, 2017

Results showed a statistically significantly, but not a clinically important, improvement in two of the trials which evaluated radiofrequency denervation for the sacroiliac joints (−0.71 (95% CI, −1.35 to −0.06) and a combination of the facet joints, sacroiliac joints or intervertebral disks (−0.99 (95% CI, −1.73 to −0.25) at 3 months.

Rituxan Biosimilar BLA Accepted for FDA Review

By June 29, 2017

The proposed indications are for the treatment of non-Hodgkin's lymphoma (NHL), chronic lymphocytic leukemia (CLL), rheumatoid arthritis (RA), granulomatosis with polyangiitis and microscopic polyangiitis.

Case: Hand Transplant Patient Develops Rheumatoid Arthritis

June 28, 2017

"To our knowledge, this is the first report of rheumatoid arthritis in a hand transplant recipient," the authors write. "Whether it constitutes an atypical transplant rejection is unclear."

Early ART Start Linked to Bone Loss in HIV Patients

By June 27, 2017

Over the 2.2 years mean follow-up, the immediate ART arm demonstrated greater BMD declines vs. the deferred ART arm at the hip (-2.5% vs. -1.0%, 95% CI: -2.2 to -0.8; P<0.001) and at the spine (-1.9% vs. -0.4%, 95% CI: -2.2 to -1.0; P<0.001).

From Treatment to Training: 5 Uses of Virtual Reality in Healthcare

June 27, 2017

Virtual reality is much more than just a new form of entertainment, it is increasingly being used in a wide range of medical applications.

Fish Consumption and RA Symptoms: What's the Link?

June 26, 2017

Researchers suggest most varieties of fish may play a role in controlling symptoms