Musculoskeletal Disorders

Does Hydroxychloroquine Improve Symptoms of Hand Osteoarthritis?

By February 20, 2018

Findings do not support the current practice of off-label use of hydroxychloroquine for treating symptomatic hand osteoarthritis.

Nusinersen Beneficial in Children With Later-Onset Spinal Muscular Atrophy

February 15, 2018

Significant improvement in motor function compared with sham procedure among children with SMA

Positive Results for Ixekizumab in the Treatment of Ankylosing Spondylitis

By February 13, 2018

Taltz demonstrated a statistically significant improvement in the signs and symptoms of AS.

Treating Endothelial Function May Target Root Disease in Marfan Syndrome

February 13, 2018

The researchers found that the MFS/ATR1a-null mice showed unabated aortic root enlargement and remained responsive to losartan, despite being hypotensive and resistant to AngII vasopressor effects.

Mogamulizumab is safe and possibly effective in HTLV-1-associated myelopathy

February 12, 2018

In this combined phase 1-2a study, mogamulizumab used for treatment of human T-lymphotropic virus type 1 (HTLV-1) associated myelopathy was safe and associated with improvement in biomarkers of disease, as well as improvements in spasticity and motor disability.

ACR Issues New Position Statement on the Use of Biosimilars

By February 07, 2018

Healthcare providers should incorporate biosimilars, where appropriate, into their regimens to treat patients with rheumatic diseases.

Does Long-Term ICS Use Increase Fracture Risk in COPD Patients?

By February 05, 2018

Long-term ICS exposure at high doses was associated with a modest but significant increase in the risk of hip or upper extremity fractures.

Antirheumatic Indications: NSAIDs

February 02, 2018

Includes drugs indicated for different types of arthritis as well as the form and strength the medication is available in.

Arthritis Treatments: NSAIDs

February 01, 2018

NSAIDS (Non-steroidal anti-inflammatory drugs) indicated for the treatment of arthritis chart.

Arthritis Treatments: DMARDS and Other Immune Modulators

February 01, 2018

A comparative list of treatment options for arthritis including DMARDS and other immune modulators.

Osteoporosis Treatments

January 31, 2018

Osteoporosis treatment and prevention doses including recommended calcium and vitamin D supplemental doses.

Medical Food Used for Managing Osteoarthritis Recalled at FDA's Request

By January 29, 2018

There have been no deaths reported with the use of Limbrel.

Weight Loss Could Improve Chronic Pain Among Obese Patients

January 29, 2018

A total of 123 obese individuals underwent a 12- to 16-week weight loss intervention with calorie restriction.

Psychoactive Drug Prescribing Linked to Nursing Facility Hip Fractures

January 29, 2018

In combination, state and facility characteristics explained 6.7% of the variation in hip fracture, and resident characteristics accounted for 7.6% of the variation.

Relationship Between Opioid Use and Patient Satisfaction Explored

January 24, 2018

The researchers found that 13.1% of patients with musculoskeletal conditions were opioid users, defined as receiving at least 1 prescription in two 6-month time periods.

Shorter overall survival among patients with monoclonal gammopathy of undetermined significance

January 23, 2018

Patients diagnosed with monoclonal gammopathy of undetermined significance (MGUS) and followed for multiple decades showed shorter overall survival rates compared to matched controls.

Onabotulinum Toxin-A Injections May Benefit Patients With Sleep Bruxism

January 18, 2018

The researchers found that clinical global impression (P<0.05) and visual analog scale of change (P<0.05) in bruxism and in pain favored the BoNT-A group.

A structured exercise program provides mobility benefits to all older patients, regardless of frailty status

January 16, 2018

The effect of physical activity at reducing the likelihood of major mobility disability (MMD) was not impacted by the baseline frailty status of patients in the study.

Trans-Capsaicin Injection Gets Fast Track Status for Knee OA Pain

By January 16, 2018

CNTX-4975 works by targeting the capsaicin receptor (TRPV1) to selectively and rapidly inactivate the local pain fibers transmitting signals to the brain.

USPSTF Updates Recommendation Statement on Scoliosis Screening

January 10, 2018

"Our review of the current evidence has pointed to more questions than answers about the benefits and harms of screening children and teenagers with no symptoms of scoliosis," said USPSTF member Alex R. Kemper, MD, MPH.

Gout Treatments

December 27, 2017

Gout treatment chart for acute attacks or chronic management/prevention.

Do Vitamin D, Calcium Supplements Cut Fracture Risk in Older Patients?

By December 26, 2017

Thirty-three randomized trials (n=51,145) were identified that met the inclusion criteria.

FDA Approves New Indication for Xeljanz, Xeljanz XR

By December 15, 2017

The new PsA approval was based on data from the Phase 3 OPAL Broaden, OPAL Beyond, and OPAL Balance studies.

Biosimilar Ixifi Gets FDA Approval for All Remicade Indications

By December 14, 2017

Ixifi is a chimeric human-murine monoclonal antibody (mAb) against tumor necrosis factor.

RAS Inhibitor Use May Cut Risk of MI in Rheumatoid Arthritis Patients

By December 08, 2017

The use of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) was associated with a reduced risk of myocardial infarction (MI) among patients with rheumatoid arthritis (RA).

Taltz Approved for the Treatment of Active Psoriatic Arthritis

By December 04, 2017

Taltz may be administered alone or in combination with a conventional disease-modifying antirheumatic drug, such as methotrexate.

Certain Drug Classes Tied to Less Frequent Driving Impairment Warnings

By December 01, 2017

More than two-thirds (85%) of those on sedatives and narcotics reported being counseled by a provider on the possibility of impaired driving.

Steroid Injection Site Linked to Bone Changes in Osteoarthritis Patients

By November 29, 2017

Their results found that 22-24% of the hip injection group had new osteonecrosis vs. 5-9% of the hip control group and to 5% of the shoulder injection group.

Hemophilic Arthropathy Treatment Gets Orphan Drug Designation

By November 27, 2017

TRM-201 (rofecoxib) is a highly potent COX-2 selective non-steroidal anti-inflammatory drug (NSAID) with a well-established efficacy profile.

FDA: Potentially Life-Threatening Adverse Events Linked to Limbrel

By November 22, 2017

The FDA is continuing to investigate Primus Pharmaceuticals and the manufacturing process for Limbrel, and will share updates as they become available.