Antares Pharma announced the publication of results from its crossover study comparing the relative bioavailability, safety, and tolerability of Otrexup (methotrexate) to oral methotrexate (MTX) in adults with rheumatoid arthritis in the Annals of the Rheumatic Diseases.
ReCept announced that it is one of the specialty pharmacies selected to distribute Otezla (apremilast; Celgene), a recently approved drug for adults with active psoriatic arthritis.
Ampio announced results of the 20 weeks extension of the SPRING study of Ampion for the treatment of osteoarthritis of the knee (OAK).
A novel therapy that involves electrical stimulation of the spinal cord has resulted in four individuals with paraplegia now being able to voluntarily move previously paralyzed muscles
The FDA has approved Otezla (apremilast; Celgene) tablets for the treatment of adults with active psoriatic arthritis.
Among U.S. patients undergoing spinal fusion, the rates of allogeneic blood transfusion increased from 2000-2009, while predonated autologous blood transfusion rates decreased.
Eagle Pharmaceuticals announced that the FDA has accepted the NDA for Ryanodex (dantrolene sodium) and has granted a priority review classification for the treatment of malignant hyperthermia.
Same-day bilateral total knee arthroplasty (BTKA) is safe in rheumatoid arthritis (RA) patients.
Neuromuscular training of all young athletes is a cost-effective strategy for reducing the costs and morbidity associated with ACL injuries.
The incidence of head and neck injuries (HNIs) resulting from participation in extreme sports increased from 2000-2011.
For patients undergoing primary total knee replacement, surgical, radiographic, and demographic variables associated with postoperative pain have been identified in two studies.
There is a substantially high rate of repeat spine imaging when patients with known spinal injuries are transferred from an outside hospital to a tertiary receiving institution.
Multiple 60-minute massage sessions are effective for neck dysfunction and pain among patients with chronic neck pain.
Oral glucosamine supplementation is not associated with a decrease in knee cartilage deterioration among individuals with chronic knee pain.
Pain Free By Nature announced a recall of Reumofan Plus Tablets because they were found to contain the following undeclared active ingredients: methocarbamol and diclofenac.
An estimated 4.5 million people are living with an artificial hip, and 6.7 million people in the United States are currently living with an artificial knee.
Receipt of a primary elective knee or hip total joint arthroplasty (TJA) for osteoarthritis (OA) provides a cardiovascular protective benefit.
Nonagenarian patients can safely undergo a total hip arthroplasty (THA), according to a recent study.
Patients undergoing lumbar spine surgery at teaching hospitals incur longer hospitalizations and have more postoperative complications compared to those treated at nonteaching hospitals.
Purdue Pharma announced results from a Phase 3 study of an extended-release formulation of hydrocodone bitartrate in patients with chronic low back pain.
Scientists can predict who will respond to NSAID treatment by assessing the nervous system's own capacity to regulate pain
For patients with spinal stenosis without degenerative spondylolisthesis, predominance of back pain versus leg pain is associated with worse surgical outcomes
Health care professionals should currently discourage rheumatology patients from using herbal cannabis as a therapy.
In patients with statin-related myalgia, single-patient randomized trials of statin and placebo can determine whether the myalgia is actually due to the statin.
For patients treated for low back pain, catastrophizing may predict the degree of pain and disability.
There is a significant association between low vitamin D status and markers of inflammation in elderly adults.
Source of funding for spinal research is significantly associated with study outcome and level of evidence.
Exposure to cigarette smoke (passive or active) is associated with lower bone mineral density (BMD) in the femoral neck and lumbar spine of men.
Regional anesthesia, including peripheral nerve block (PNB), does not increase the risk of inpatient falls (IFs) after total knee arthroplasty (TKA).
Anika Therapeutics received FDA marketing approval for Monovisc (sodium hyaluronate [NaHA] in phosphate buffered saline) for the treatment of osteoarthritis (OA) of the knee.
Fever during pregnancy is associated with adverse health outcomes for the offspring.
Pfizer announced that the FDA has approved a sNDA to update the current label of Xeljanz (tofacitinib citrate) tablets to include radiographic data from two Phase 3 studies, ORAL Scan and ORAL Start.
The FDA has accepted Auxilium's supplemental Biologics License Application (sBLA) for Xiaflex (collagenase clostridium histolyticum, or CCH) for the treatment of two Dupuytren's contracture (DC) cords concurrently.
For patients recovering from musculoskeletal trauma, psychological factors, especially catastrophic thinking, are associated with pain intensity and disability.
In chronic disabling occupational lumbar disorder (CDOLD), lumbar fusion outcomes can be improved if opioid dependence and excessive length of disability after surgery are controlled through care.
Obesity is associated with more complex supracondylar humeral fractures in children, as well as with a greater risk of postoperative complications.
For older patients, a home-based exercise program is beneficial after formal hip fracture rehabilitation has ended,
For patients undergoing lower-extremity arthroplasty, a mobile compression device is noninferior to pharmacological protocols for the prevention of venous thromboembolism.
The FDA announced the approval of Vimizim (elosulfase alfa; BioMarin) for the treatment of Mucopolysaccharidosis Type IVA (Morquio A syndrome).
For older men, walking is associated with reduced risk of hip fracture, with more walking and brisker walking correlating with greater risk reduction.
Higher preoperative levels of pain and anxiety may be risk factors for chronic postsurgical pain for patients with adolescent idiopathic scoliosis (AIS) undergoing posterior spinal fusion.
For patients discharged from inpatient rehabilitation facilities, 30-day readmission rates are 11.8% overall.
Pennsaid (diclofenac sodium; Mallinckrodt) topical solution 2% w/w is now available.
Patients with or without diabetes experienced similar outcomes of laminoplasty for cervical spondylotic myelopathy.
Patients with back pain and degenerative disc disease (DDD) have different patterns of lumbar disc degeneration than patients with disc prolapse (DP).
Researchers have developed the first evidence-based diagnostic criteria for temporomandibular disorders (TMD).
A new model can predict the risk of medical complications, including major complications, after spine surgery.
Marital history, including disruptions and age at marriage, is associated with bone health in men, while marital support correlates with bone health in women.
For patients undergoing spinal fusion for adolescent idiopathic scoliosis (AIS), low body mass index (BMI) is associated with greater percent correction of thoracic curves.
Medac Pharma announced that the FDA has accepted for review its New Drug Application (NDA) for its lead product candidate MPI-2505 (methotrexate).
Hormone replacement therapy use (HRT) is associated with a reduction in revision rates for total knee arthroplasty (TKA) and total hip arthroplasty (THA).
The total economic cost to society for treatment of severe knee osteoarthritis is considerably lower with total knee arthroplasty than with nonoperative treatment.
The likelihood of experiencing worse pain at six months post-surgery is increased with a waiting time of 12 weeks or more for elective surgical lumbar discectomy (ESLD).
Most patients with spinal cord injury (SCI) have sleep disordered breathing (SDB).
The FDA has approved Mallinckrodt's NDA Pennsaid (diclofenac sodium) topical solution 2% w/w.
Childhood distal forearm fractures (DFFs) have two distinct etiologies.
The FDA has accepted for review the supplemental New Drug Application (sNDA) for Zorvolex (diclofenac; Iroko), a lower dose nonsteroidal anti-inflammatory drug (NSAID) for the treatment of osteoarthritis pain in adults.
Antares Pharma announced the availability of Otrexup (methotrexate for subcutaneous injection) for once-weekly self-administration with a single-dose disposable auto-injector.
Surgical hospitalization rates for lumbar spinal stenosis vary substantially across racial and ethnic groups.
Rates and patterns of shoulder injuries vary by sport and gender in high school athletes.
Researchers found that 60-day mortality rates significantly improved from 2004-2007 compared with 1989-1991.
For women from South China, breastfeeding is associated with reduced risk of rheumatoid arthritis (RA), especially a longer duration of breastfeeding.
Romosozumab seems safe and effective for increasing bone mineral density in postmenopausal women with low bone mineral density.
Mortality rates are higher in postmenopausal women with rheumatoid arthritis (RA) who have anti-cyclic citrullinated peptide (anti-CCP) antibodies.
Outcomes after arthroscopic partial meniscectomy are no better than outcomes after sham surgery in patients with knee symptoms due to an apparent degenerative medial meniscus tear.
The predictive ability for back injuries from manual handling was acceptable during the long term.
Evidence-based clinical guidelines have been developed for management of lumbar disc herniation with radiculopathy.
The FDA is advising consumers to immediately discontinue use of Mass Destruction, a dietary supplement marketed for muscle growth.
In 2011, 7.8 percent of components were implanted despite lack of evidence for clinical effectiveness.
Auxilium announced that it has submitted a supplemental Biologics License Application (sBLA) to the FDA for Xiaflex (collagenase clostridium histolyticum) for the treatment of multiple Dupuytren's contracture (DC) cords concurrently.
For patients undergoing spinal surgery for a structural lesion, preoperative depression and anxiety are associated with increased preoperative narcotic use.
For patients undergoing decompression for degenerative stenosis, the incidence of epidural hematoma is similar for different surgical approaches; however, there is a tendency toward increased postoperative hematoma in approaches with greater bony decompression area.
Patients admitted to the hospital on weekends for cervical spine fusion resulting from trauma have a greater length of stay and total hospital costs than their weekday counterparts.
The nerve root sedimentation sign, seen on magnetic resonance images, can differentiate lumbar spinal stenosis from asymptomatic controls.
Smaller micropolitan areas, mainly, have no practicing rheumatologists.
There were no significant differences between the referring groups in the mean total number of positive abnormality subtypes per image.
Patients with rheumatoid arthritis experience significantly less psychological stress and physical disability compared with two decades ago, which may be partially due to a reduction in disease activity.
Improvement in functionality, reduction in pain for athletes with Achilles or patellar tendinosis were seen.
Combo of hypoxia treatment, overground walking linked to gains in speed, endurance.
The addition of gabapentin to patient-controlled analgesia (PCA) protocol does not reduce morphine consumption, pain, or opioid-related side effects in patients undergoing total knee arthroplasty.
Sanofi and Regeneron announced that in the SARIL-RA-MOBILITY Phase 3 clinical trial, sarilumab in combination with methotrexate (MTX) improved disease signs and symptoms as well as physical function, and inhibited progression of joint damage in adult patients with active rheumatoid arthritis (RA) who were inadequate responders to MTX therapy.
Researchers find that greater milk consumption during teenage years is not associated with a lower risk of hip fracture in older adults.
Mean levels of total 25-hydroxyvitamin D and vitamin D-binding protein were significantly lower in blacks than in whites.
Pfizer announced that the FDA has approved the supplemental New Drug Application (sNDA) for Xeljanz (tofacitinib citrate) to include additional patient-reported outcomes data in the label.
Short-term chiropractic treatment was superior to sham; however, treatment effects were not clinically important.
BioSpecifics Technologies has announced positive results from its Phase 3b MULTICORD study evaluating Xiaflex (collagenase clostridium histolyticum) for the concurrent treatment of adult Dupuytren's contracture patients with multiple palpable cords.
Recommendations from health care providers are linked with adherence to guidelines for physical activity in adults with arthritis.
Surgeons have dissected and described a new structure in the human knee joint, the anterolateral ligament (ALL), which connects the femur with the anterolateral tibia.
Self-management education and appropriate physical activity can improve outcomes.
Beginning rehabilitation at six weeks as opposed to 12 weeks post-lumbar spinal fusion is associated with higher costs and poorer outcomes.
For Medicare patients with new vertebral compression fractures, kyphoplasty correlates with lower risk of death, but with increased likelihood of subsequent augmentation procedures compared with vertebroplasty.
The top five pediatric rheumatology-related issues that physicians and patients should question have been released by the American College of Rheumatology (ACR) as part of the Choosing Wisely campaign.
Health providers need to provide correct advice about how to swaddle infants safely, to reduce the risk of hip dysplasia.
Over the past decade, pediatric methicillin-resistant Staphylococcus aureus (MRSA) musculoskeletal infections have increased in frequency.
Patients meeting strict criteria benefit more from surgery for degenerative spondylolisthesis (DS), compared to non-operative care, although the treatment effect of surgery is modified by specific patient characteristics.
Musculoskeletal pain in the low back, hips, and the nonoperatively treated knee before total knee replacement is associated with poorer physical function at six months after surgery.
In patients who undergo total hip and knee arthroplasty, 5% have unplanned readmission within 90 days.
Recovery room radiographs provide no incremental clinical value above intraoperative images following lumbar fusion.
Genentech announced that the FDA has approved a subcutaneous (SC) formulation of Actemra (tocilizumab) for the treatment of adults with moderately-to-severely active rheumatoid arthritis (RA).