Otrexup Results Published for Rhuematoid Arthritis

Antares Pharma announced the publication of results from its crossover study comparing the relative bioavailability, safety, and tolerability of Otrexup (methotrexate) to oral methotrexate (MTX) in adults with rheumatoid arthritis in the Annals of the Rheumatic Diseases.

First Oral Psoriatic Arthritis Drug Launched in Specialty Pharmacies

ReCept announced that it is one of the specialty pharmacies selected to distribute Otezla (apremilast; Celgene), a recently approved drug for adults with active psoriatic arthritis.

Results Reinforce Ampion Use in OAK

Ampio announced results of the 20 weeks extension of the SPRING study of Ampion for the treatment of osteoarthritis of the knee (OAK).

Paralyzed Patients Move Muscles with Spinal Stimulation

A novel therapy that involves electrical stimulation of the spinal cord has resulted in four individuals with paraplegia now being able to voluntarily move previously paralyzed muscles

New Oral Tablets Approved for Psoriatic Arthritis

The FDA has approved Otezla (apremilast; Celgene) tablets for the treatment of adults with active psoriatic arthritis.

Blood Transfusions for Spinal Fusion Holding Steady

Among U.S. patients undergoing spinal fusion, the rates of allogeneic blood transfusion increased from 2000-2009, while predonated autologous blood transfusion rates decreased.

Priority Review Granted for Malignant Hyperthermia Drug

Eagle Pharmaceuticals announced that the FDA has accepted the NDA for Ryanodex (dantrolene sodium) and has granted a priority review classification for the treatment of malignant hyperthermia.

Same-Day Double Knee Replacement Safe With RA

Same-day bilateral total knee arthroplasty (BTKA) is safe in rheumatoid arthritis (RA) patients.

Training Young Athletes Could Prevent ACL Injury

Neuromuscular training of all young athletes is a cost-effective strategy for reducing the costs and morbidity associated with ACL injuries.

Increase in Extreme Sport Head, Neck Injuries

The incidence of head and neck injuries (HNIs) resulting from participation in extreme sports increased from 2000-2011.

Risk Factors ID'd for Post-Knee Replacement Pain

For patients undergoing primary total knee replacement, surgical, radiographic, and demographic variables associated with postoperative pain have been identified in two studies.

Repeat Spine Imaging Frequent With Injured Patient Transfers

There is a substantially high rate of repeat spine imaging when patients with known spinal injuries are transferred from an outside hospital to a tertiary receiving institution.

Longer Massage Sessions Effective for Neck Pain

Multiple 60-minute massage sessions are effective for neck dysfunction and pain among patients with chronic neck pain.

Glucosamine for Knee Cartilage Studied

Oral glucosamine supplementation is not associated with a decrease in knee cartilage deterioration among individuals with chronic knee pain.

Pain Supplement Recall Due to Hidden Ingredients

Pain Free By Nature announced a recall of Reumofan Plus Tablets because they were found to contain the following undeclared active ingredients: methocarbamol and diclofenac.

Challenges Ahead for Artificial Hip, Knee Services

An estimated 4.5 million people are living with an artificial hip, and 6.7 million people in the United States are currently living with an artificial knee.

Knee, Hip Arthroplasty Provides Cardiovascular Benefit

Receipt of a primary elective knee or hip total joint arthroplasty (TJA) for osteoarthritis (OA) provides a cardiovascular protective benefit.

Evaluating Total Hip Arthroplasty in Nonagenarians

Nonagenarian patients can safely undergo a total hip arthroplasty (THA), according to a recent study.

More Lumbar Sx Complications at Certain Hospitals

Patients undergoing lumbar spine surgery at teaching hospitals incur longer hospitalizations and have more postoperative complications compared to those treated at nonteaching hospitals.

Extended-Release Drug for Chronic Low Back Pain Meets Endpoint

Purdue Pharma announced results from a Phase 3 study of an extended-release formulation of hydrocodone bitartrate in patients with chronic low back pain.

Internal Opioid System Predicts NSAID Tx Response for Neuropathic Pain

Scientists can predict who will respond to NSAID treatment by assessing the nervous system's own capacity to regulate pain

Pre-Op Pain Patterns Affect Stenosis Surgery Outcomes

For patients with spinal stenosis without degenerative spondylolisthesis, predominance of back pain versus leg pain is associated with worse surgical outcomes

Marijuana Not Recommended for Rheumatic Conditions

Health care professionals should currently discourage rheumatology patients from using herbal cannabis as a therapy.

Single-Patient Trials Determine Statin Tolerability

In patients with statin-related myalgia, single-patient randomized trials of statin and placebo can determine whether the myalgia is actually due to the statin.

Catastrophizing Can Predict Low Back Pain, Disability

For patients treated for low back pain, catastrophizing may predict the degree of pain and disability.

Vitamin D Tied to Markers of Inflammation in Elderly

There is a significant association between low vitamin D status and markers of inflammation in elderly adults.

Spinal Study Outcomes, Levels of Evidence Tied to Funding

Source of funding for spinal research is significantly associated with study outcome and level of evidence.

Cigarette Smoke Exposure Affects Bone Mineral Density

Exposure to cigarette smoke (passive or active) is associated with lower bone mineral density (BMD) in the femoral neck and lumbar spine of men.

Regional Anesthesia Doesn't Up Falls After Knee Replacement

Regional anesthesia, including peripheral nerve block (PNB), does not increase the risk of inpatient falls (IFs) after total knee arthroplasty (TKA).

First Non-Animal HA Inj for Knee Osteoarthritis Approved

Anika Therapeutics received FDA marketing approval for Monovisc (sodium hyaluronate [NaHA] in phosphate buffered saline) for the treatment of osteoarthritis (OA) of the knee.

Fever During Pregnancy Associated With Birth Defects

Fever during pregnancy is associated with adverse health outcomes for the offspring.

Xeljanz Label Gains Radiographic Data Addition

Pfizer announced that the FDA has approved a sNDA to update the current label of Xeljanz (tofacitinib citrate) tablets to include radiographic data from two Phase 3 studies, ORAL Scan and ORAL Start.

FDA Accepts sBLA for Xiaflex for Concurrent Treatment of Multiple Palpable Cords

The FDA has accepted Auxilium's supplemental Biologics License Application (sBLA) for Xiaflex (collagenase clostridium histolyticum, or CCH) for the treatment of two Dupuytren's contracture (DC) cords concurrently.

Psychological Factors Affect Skeletal Trauma Recovery

For patients recovering from musculoskeletal trauma, psychological factors, especially catastrophic thinking, are associated with pain intensity and disability.

Surgeons Can Up Outcomes for Work-Related Lumbar Surgery

In chronic disabling occupational lumbar disorder (CDOLD), lumbar fusion outcomes can be improved if opioid dependence and excessive length of disability after surgery are controlled through care.

Obesity Complicates Elbow Fractures in Children

Obesity is associated with more complex supracondylar humeral fractures in children, as well as with a greater risk of postoperative complications.

Home Exercise Program Boosts Physical Function After Rehab

For older patients, a home-based exercise program is beneficial after formal hip fracture rehabilitation has ended,

Compression Device Noninferior to Meds Post-Arthroplasty

For patients undergoing lower-extremity arthroplasty, a mobile compression device is noninferior to pharmacological protocols for the prevention of venous thromboembolism.

New Treatment for Rare Congenital Enzyme Disorder

The FDA announced the approval of Vimizim (elosulfase alfa; BioMarin) for the treatment of Mucopolysaccharidosis Type IVA (Morquio A syndrome).

More Walking, Brisk Walking Lower Hip Fx Risk in Older Men

For older men, walking is associated with reduced risk of hip fracture, with more walking and brisker walking correlating with greater risk reduction.

Predictors of Post-Op Pain ID'd in Adolescent Idiopathic Scoliosis

Higher preoperative levels of pain and anxiety may be risk factors for chronic postsurgical pain for patients with adolescent idiopathic scoliosis (AIS) undergoing posterior spinal fusion.

30-Day Readmission From Postacute Rehab 11.8%

For patients discharged from inpatient rehabilitation facilities, 30-day readmission rates are 11.8% overall.

Pennsaid 2% Solution Now Available

Pennsaid (diclofenac sodium; Mallinckrodt) topical solution 2% w/w is now available.

Diabetes Does Not Worsen Outcomes of Cervical Laminoplasty

Patients with or without diabetes experienced similar outcomes of laminoplasty for cervical spondylotic myelopathy.

MRI Patterns in Disc Prolapse, Degenerative Disease Described

Patients with back pain and degenerative disc disease (DDD) have different patterns of lumbar disc degeneration than patients with disc prolapse (DP).

First Diagnostic Criteria for TMJ Published

Researchers have developed the first evidence-based diagnostic criteria for temporomandibular disorders (TMD).

Model Can Predict Spine Surgery Complications

A new model can predict the risk of medical complications, including major complications, after spine surgery.

Marital History, Support Linked to Bone Health

Marital history, including disruptions and age at marriage, is associated with bone health in men, while marital support correlates with bone health in women.

Low BMI Tied to Better Surgical Scoliosis Curve Correction

For patients undergoing spinal fusion for adolescent idiopathic scoliosis (AIS), low body mass index (BMI) is associated with greater percent correction of thoracic curves.

FDA to Review MPI-2505 NDA for RA, Psoriasis

Medac Pharma announced that the FDA has accepted for review its New Drug Application (NDA) for its lead product candidate MPI-2505 (methotrexate).

Hormone Therapy Linked to Arthroplasty Revision

Hormone replacement therapy use (HRT) is associated with a reduction in revision rates for total knee arthroplasty (TKA) and total hip arthroplasty (THA).

Total Knee Arthroplasty Has Economic Benefit for Society

The total economic cost to society for treatment of severe knee osteoarthritis is considerably lower with total knee arthroplasty than with nonoperative treatment.

Wait Time to Lumbar Discectomy Linked to Post-Op Pain

The likelihood of experiencing worse pain at six months post-surgery is increased with a waiting time of 12 weeks or more for elective surgical lumbar discectomy (ESLD).

Sleep Disordered Breathing Common With Spinal Cord Injury

Most patients with spinal cord injury (SCI) have sleep disordered breathing (SDB).

New Pennsaid Solution Strength Approved

The FDA has approved Mallinckrodt's NDA Pennsaid (diclofenac sodium) topical solution 2% w/w.

Two Distinct Etiologies for Distal Forearm Fractures in Childhood

Childhood distal forearm fractures (DFFs) have two distinct etiologies.

FDA to Review Zorvolex for Osteoarthritis Pain

The FDA has accepted for review the supplemental New Drug Application (sNDA) for Zorvolex (diclofenac; Iroko), a lower dose nonsteroidal anti-inflammatory drug (NSAID) for the treatment of osteoarthritis pain in adults.

Otrexup Injection Launched for RA, Psoriasis

Antares Pharma announced the availability of Otrexup (methotrexate for subcutaneous injection) for once-weekly self-administration with a single-dose disposable auto-injector.

Lumbar Spinal Stenosis Surgery Rates Vary by Race

Surgical hospitalization rates for lumbar spinal stenosis vary substantially across racial and ethnic groups.

Patterns of Shoulder Injuries Vary in High School Sports

Rates and patterns of shoulder injuries vary by sport and gender in high school athletes.

Survival Improving After Hip and Knee Replacement

Researchers found that 60-day mortality rates significantly improved from 2004-2007 compared with 1989-1991.

Breastfeeding Linked to Reduced RA Risk in Chinese Women

For women from South China, breastfeeding is associated with reduced risk of rheumatoid arthritis (RA), especially a longer duration of breastfeeding.

Romosozumab Increases Bone Mineral Density Post-Menopause

Romosozumab seems safe and effective for increasing bone mineral density in postmenopausal women with low bone mineral density.

Mortality Up in Postmenopausal Women With Anti-CCP+ RA

Mortality rates are higher in postmenopausal women with rheumatoid arthritis (RA) who have anti-cyclic citrullinated peptide (anti-CCP) antibodies.

Meniscus Tear Surgery No Better Than Sham Surgery

Outcomes after arthroscopic partial meniscectomy are no better than outcomes after sham surgery in patients with knee symptoms due to an apparent degenerative medial meniscus tear.

Pre-Employment Assessment Tool Can Predict Injury Risk

The predictive ability for back injuries from manual handling was acceptable during the long term.

Evidence-Based Guidelines Developed for Disc Herniation

Evidence-based clinical guidelines have been developed for management of lumbar disc herniation with radiculopathy.

Liver Injury Linked to Muscle Growth Supplement

The FDA is advising consumers to immediately discontinue use of Mass Destruction, a dietary supplement marketed for muscle growth.

No Evidence for Clinical Effectiveness of Many Hip Implants

In 2011, 7.8 percent of components were implanted despite lack of evidence for clinical effectiveness.

Auxilium Submits Xiaflex sBLA for Concurrent Treatment Of Multiple Palpable Cords

Auxilium announced that it has submitted a supplemental Biologics License Application (sBLA) to the FDA for Xiaflex (collagenase clostridium histolyticum) for the treatment of multiple Dupuytren's contracture (DC) cords concurrently.

Pre-Op Depression Linked to Narcotic Use Before Spinal Sx

For patients undergoing spinal surgery for a structural lesion, preoperative depression and anxiety are associated with increased preoperative narcotic use.

Post-Op Hematoma Incidence Similar for Decompression Types

For patients undergoing decompression for degenerative stenosis, the incidence of epidural hematoma is similar for different surgical approaches; however, there is a tendency toward increased postoperative hematoma in approaches with greater bony decompression area.

Weekend Spine Surgery Linked to Longer Stays, Higher Costs

Patients admitted to the hospital on weekends for cervical spine fusion resulting from trauma have a greater length of stay and total hospital costs than their weekday counterparts.

Nerve Root Sedimentation Sign for Spinal Stenosis Assessed

The nerve root sedimentation sign, seen on magnetic resonance images, can differentiate lumbar spinal stenosis from asymptomatic controls.

Some Areas of United States Have No Rheumatologists

Smaller micropolitan areas, mainly, have no practicing rheumatologists.

Financial Interest May Motivate Higher Knee MRI Referral

There were no significant differences between the referring groups in the mean total number of positive abnormality subtypes per image.

Disability Decreased in Arthritis Patients Over Past 20 Years

Patients with rheumatoid arthritis experience significantly less psychological stress and physical disability compared with two decades ago, which may be partially due to a reduction in disease activity.

Platelet Rich Plasma Treatments Beneficial for Tendinosis

Improvement in functionality, reduction in pain for athletes with Achilles or patellar tendinosis were seen.

Low Oxygen Exposure May Aid Walking With Spinal Injury

Combo of hypoxia treatment, overground walking linked to gains in speed, endurance.

Gabapentin Doesn't Cut Use of Morphine Post-Knee Arthroplasty

The addition of gabapentin to patient-controlled analgesia (PCA) protocol does not reduce morphine consumption, pain, or opioid-related side effects in patients undergoing total knee arthroplasty.

Sarilumab Demonstrates Efficacy in Rheumatoid Arthritis Trial

Sanofi and Regeneron announced that in the SARIL-RA-MOBILITY Phase 3 clinical trial, sarilumab in combination with methotrexate (MTX) improved disease signs and symptoms as well as physical function, and inhibited progression of joint damage in adult patients with active rheumatoid arthritis (RA) who were inadequate responders to MTX therapy.

Drinking Milk As Teen Not Tied to Later Hip Fracture Risk

Researchers find that greater milk consumption during teenage years is not associated with a lower risk of hip fracture in older adults.

Race May Affect Assessment of Vitamin D Status

Mean levels of total 25-hydroxyvitamin D and vitamin D-binding protein were significantly lower in blacks than in whites.

FDA Approves Additional Labeling for Xeljanz

Pfizer announced that the FDA has approved the supplemental New Drug Application (sNDA) for Xeljanz (tofacitinib citrate) to include additional patient-reported outcomes data in the label.

Chiropractic Care Beats Sham Therapy for Spinal Pain

Short-term chiropractic treatment was superior to sham; however, treatment effects were not clinically important.

Positive Results for Xiaflex in MULTICORD Study

BioSpecifics Technologies has announced positive results from its Phase 3b MULTICORD study evaluating Xiaflex (collagenase clostridium histolyticum) for the concurrent treatment of adult Dupuytren's contracture patients with multiple palpable cords.

Arthritis Patients Listen When Doc Tells Them to Exercise

Recommendations from health care providers are linked with adherence to guidelines for physical activity in adults with arthritis.

Surgeons Identify New Ligament in the Knee

Surgeons have dissected and described a new structure in the human knee joint, the anterolateral ligament (ALL), which connects the femur with the anterolateral tibia.

CDC: More Than 1 in 5 Adults Report Having Arthritis

Self-management education and appropriate physical activity can improve outcomes.

Worse Outcomes for Early Post-Lumbar Spinal Fusion Rehab

Beginning rehabilitation at six weeks as opposed to 12 weeks post-lumbar spinal fusion is associated with higher costs and poorer outcomes.

Study Compares Treatments for Vertebral Compression Fx

For Medicare patients with new vertebral compression fractures, kyphoplasty correlates with lower risk of death, but with increased likelihood of subsequent augmentation procedures compared with vertebroplasty.

ACR Issues Five Peds Choosing Wisely Recommendations

The top five pediatric rheumatology-related issues that physicians and patients should question have been released by the American College of Rheumatology (ACR) as part of the Choosing Wisely campaign.

'Safe Swaddling' Recommended to Prevent Hip Dysplasia

Health providers need to provide correct advice about how to swaddle infants safely, to reduce the risk of hip dysplasia.

AAP: Rise Seen in Pediatric MRSA Musculoskeletal Infections

Over the past decade, pediatric methicillin-resistant Staphylococcus aureus (MRSA) musculoskeletal infections have increased in frequency.

Spine Surgery Patients Meeting Strict Criteria Benefit More

Patients meeting strict criteria benefit more from surgery for degenerative spondylolisthesis (DS), compared to non-operative care, although the treatment effect of surgery is modified by specific patient characteristics.

Coexisting Pain Tied to Worse Knee Replacement Outcomes

Musculoskeletal pain in the low back, hips, and the nonoperatively treated knee before total knee replacement is associated with poorer physical function at six months after surgery.

>5 Percent Readmitted After Total Joint Arthroplasty

In patients who undergo total hip and knee arthroplasty, 5% have unplanned readmission within 90 days.

Recovery Room Imaging Has No Extra Value Post-Lumbar Fusion

Recovery room radiographs provide no incremental clinical value above intraoperative images following lumbar fusion.

FDA Approves New Actemra SC Formulation

Genentech announced that the FDA has approved a subcutaneous (SC) formulation of Actemra (tocilizumab) for the treatment of adults with moderately-to-severely active rheumatoid arthritis (RA).

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