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Morphine sulfate oral solution

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Generic Name for Morphine sulfate oral solution

Morphine sulfate 10mg/5mL, 20mg/5mL, 100mg/5mL.

Legal Classification:

CII

Pharmacological Class for Morphine sulfate oral solution

Opioid.

Manufacturer of Morphine sulfate oral solution

Roxane Laboratories, Inc.

Indications for Morphine sulfate oral solution

Moderate to severe pain. 100mg/5mL strength: for use in opioid-tolerant patients only.

Adult dose for Morphine sulfate oral solution

Individualize and periodically reevaluate dose. Tabs: usually 15–30mg every 4hrs as needed. Soln: usually 10–20mg every 4hrs as needed.

Children's dosing for Morphine sulfate oral solution

<18yrs: not recommended.

Also:

Morphine sulfate tablets

Contraindications for Morphine sulfate oral solution

Respiratory depression in the absence of resuscitative equipment. Acute or severe asthma or hypercarbia. Paralytic ileus.

Warnings/Precautions for Morphine sulfate oral solution

Avoid dosing errors between different concentrations or between mg and mL. Head injury. Increased intracranial pressure. Shock. Severe renal or hepatic impairment. Impaired pulmonary, thyroid, or adrenocortical function. GI or GU obstruction. Acute abdomen. Biliary tract disease. Acute pancreatitis. Kyphoscoliosis. Convulsive disorders. Drug abusers. Delirium tremens. Elderly. Debilitated. Pregnancy (Cat.C). Labor & delivery, nursing mothers: not recommended.

Interactions for Morphine sulfate oral solution

Potentiation with alcohol, CNS depressants, anticholinergics, MAOIs, phenothiazines, general anesthetics, antiemetics, p-glycoprotein inhibitors (eg, quinidine). Do not use within 14 days of MAOIs. Severe hypotension with phenothiazines, general anesthetics. Potentiates neuromuscular blockers. Monitor cimetidine. Possible withdrawal symptoms with mixed opioid agonist/antagonists.

Adverse Reactions for Morphine sulfate oral solution

Somnolence, constipation, GI upset, lightheadedness, dizziness, sedation, sweating, respiratory depression, orthostatic hypotension, syncope, euphoria.

How is Morphine sulfate oral solution supplied?

Tabs—100; Soln (10mg/5mL, 20mg/5mL)—100mL, 500mL; (100mg/5mL)—30mL, 120mL (w. oral syringe)

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