Mood Disorders

Paternal SSRI Use Before Conception Linked to Offspring ADHD

December 11, 2017

After adjustment for potential confounders, exposed children had a 26% increased risk of ADHD compared with unexposed children.

Certain Drug Classes Tied to Less Frequent Driving Impairment Warnings

By December 01, 2017

More than two-thirds (85%) of those on sedatives and narcotics reported being counseled by a provider on the possibility of impaired driving.

Are Network Characteristics Prognostic for Long-Term Outcomes in Depression?

December 01, 2017

The researchers found that good responders had higher mean MFQ summary scores at baseline and higher mean levels of suicidality than poor responders.

Physician Burnout Associated With Significant Financial Costs

November 22, 2017

Economic loss at Stanford over two years expected to range from 15.5 million to 55.5 million

Impact of Psoriasis Treatments on Depressive Symptoms Examined

By November 20, 2017

Psoriasis patients may be at increased risk for depression and suicidality.

Impact of Peer Review PA on Child Atypical Antipsychotic Use

November 16, 2017

Researchers used Medicaid administrative claims data from 4 geographically diverse states to examine the impact of peer review PA policies on AAP use among Medicaid-insured youth.

FDA Approves Antipsychotic Agent With Sensor to Track Ingestion

By November 14, 2017

The product is approved for the treatment of schizophrenia, acute treatment of manic and mixed episodes associated with bipolar I disorder and for use as an add-on treatment for depression in adults.

Vraylar Approved as Maintenance Treatment for Schizophrenia

By November 13, 2017

Results showed that cariprazine significantly delayed the time to relapse compared to placebo (P=0.0010). A total of 49.5% (n=49/99) of placebo treated patients relapsed vs. 29.7% (n=30/101) for the cariprazine treated patients.

Does Continuing Lithium Tx in CKD Patients Up the Risk of End-Stage CKD?

By November 10, 2017

In the subcohorts of patients with a diagnosis of bipolar disorder, continuing lithium was associated with decreased end-stage CKD, whereas continuing anticonvulsants was not.

Positive Results for Brexanolone in Postpartum Depression Trials

By November 10, 2017

The Hummingbird Phase 3 program included two Phase 3, multicenter, randomized, double-blind, parallel-group, placebo-controlled trials designed to evaluate the safety and effectiveness of brexanolone in women with moderate and severe PPD.

How Computerized CBT May Aid Depression, Anxiety

November 09, 2017

Completing more CCBT sessions was correlated with greater effect size improvements in mental health-related quality of life and symptoms.

Omega-3 Supplementation Linked to Improved Executive Functioning

By November 08, 2017

In children with mood disorders, Ω3 supplementation was found to decrease impairment in executive function.

Sertraline May Not Benefit Non-Dialysis Dependent CKD Patients With MDD

November 07, 2017

The researchers found that there was a change in the 16-item Quick Inventory of Depression Symptomatology-Clinician Rated of −4.1 in the sertraline group and −4.2 in the placebo group.

Depression Examined During Physician's Internship Year

October 31, 2017

Researchers conducted a prospective longitudinal cohort study of medical internship in the United States in which 3,121 interns (49.7% women) were recruited across all specialties from 44 medical institutions.

Valbenazine Granted Orphan Drug Designation for Tourette Syndrome

By October 25, 2017

Valbenazine is already approved and marketed as Ingrezza in the US to treat adults with tardive dyskinesia

Non-Invasive 'Neuro-Laser' Found to Be Effective for Depression

By October 23, 2017

Results showed that 36 of the 39 participants experienced "a robust response" (decrease of QIDS total score by ≥50%) after 16.82 ± 6.26 treatments.

HBOT Linked to Significant Reduction in PTSD Symptoms

By October 20, 2017

Following completion of all treatments 12 (52%) of the 23 subjects who initially met PTSD Checklist-Military (PCL-M) for diagnosis no longer met the threshold criteria.

Licensure Concerns May Be a Barrier to Clinicians Seeking Mental Health Tx

By October 11, 2017

The survey revealed that almost 40% of physicians would be reluctant to seek formal medical care for treatment of a mental health condition due to perceived repercussions to their medical licensure.

Exercise and Depression Prevention: What's the Link?

October 03, 2017

Correlation was seen for future depression, but not anxiety, regardless of intensity of exercise

Psychosocial Intervention Improves Antidepressant Adherence

September 28, 2017

"The Treatment Initiation and Participation Program is an effective intervention to improve early adherence to pharmacotherapy," the authors write. "Improved adherence can promote improvement in depression."

Suicidal Ingestion Outcomes Compared Between Bupropion and TCAs

By September 26, 2017

Results showed that bupropion users were more likely to have a seizure, have accompanied tachycardia on presentation, and be admitted to the hospital, compared to those who ingested a TCA.

FDA Rejects Vraylar sNDA for Negative Symptoms of Schizophrenia

By September 25, 2017

In the letter the FDA stated that their preliminary appraisal found that the sNDA was not sufficiently complete to permit a substantive review.

Increased Med Use Over Time Seen in Older Patients of All BMI Classes

By September 22, 2017

Researchers aimed to determine whether the rise in prescription drug use over time varied by age and obesity status.

Asthma Drug Linked to Neuropsychiatric Adverse Events

By September 21, 2017

Results found that overall depression was the most commonly reported adverse event in the VigiBase group while headaches were the most frequent adverse event reported for the Dutch database.

Sleep Deprivation: An Effective Antidepressant?

By September 21, 2017

Researchers from the Perelman School of Medicine at the University of Pennsylvania analyzed 66 studies to determine the antidepressant effects of sleep deprivation.

Intranasal Ketamine Evaluated in Fear of Harm Bipolar Phenotype

By September 20, 2017

Findings showed that almost all patients were 'much' to 'very much' improved clinically and in ratings of social function and academic performance.

Depression Found to Be Independently Associated with Recurrent Chest Pain

By September 20, 2017

On multivariable regression models, depression was a significant independent predictor of 30-day chest pain recurrence after adjustment.

Lithium May Be Underused as Antisuicidal Agent, Review Finds

By September 19, 2017

Despite the abundance of evidence published in the past 40 years supporting lithium as an antisuicidal agent, its use is "underrepresented" and should be incorporated into clinical guidelines and practice more assertively.

Suicide Attempts Up; Particularly Evident Among Young Women

September 14, 2017

The researchers observed an increase in the weighted percentage of U.S. adults making a recent suicide attempt from 0.62% in 2004 to 2005 to 0.79% in 2012 to 2013 (risk difference adjusted for age, sex, and race/ethnicity [ARD], 0.17%).

Anxiety Disorders and Maternal, Fetal Outcomes Investigated

September 14, 2017

The researchers observed no correlation for panic disorder or GAD with maternal or neonatal complications of interest, in adjusted models.