Mood Disorders

Sedation Level Does Not Impact Delirium Risk After Hip Fx Repair

August 13, 2018

The researchers found that the overall incident delirium risk was 36.5%; 39 vs 34%, respectively, in the heavier and lighter sedation groups (P=.46).

Antidepressants and Bleeding Risk: What's the Link?

By August 08, 2018

Results showed an increased risk of bleeding with SRIs by 1.16-2.36 times with an even higher 3.17- to 10.9-fold risk with concomitant NSAIDs.

CDC: Use of Unapproved Opioid-Like Antidepressant on the Rise in the US

By August 07, 2018

While approved in Europe, Asia, and Latin America, tianeptine, an opioid receptor agonist, is an unscheduled pharmaceutical agent in the US that has been linked to serious adverse events, including death, when used for recreational purposes.

Medical Boards May Contribute to Mental Health Stigma for Doctors

July 31, 2018

Many state medical boards persist in questioning licensure applicants about their history of treatment for mental health instead of focusing on their current fitness to practice.

Phase 3 Trial of Potential PTSD Treatment Halted

By July 27, 2018

Participants in the trial were randomized to receive Tonmya 5.6mg sublingually at bedtime for 12 weeks or placebo sublingual tablets.

Off-Label Prescribing Common With Certain Psychiatric Medications

By July 26, 2018

Using data from the 2012 and 2013 National Ambulatory Medical Care Surveys, researchers looked at all adult outpatient visits to psychiatric practices for chronic care management in which ≥1 psychiatric medication was prescribed.

Prevalence of Depression 4.4% Among Dads of Infants

July 25, 2018

Overall, 4.4% of the fathers who answered the PSF screened positive for depression, which was comparable to the 5.0% of mothers who screened positive. Fathers accounted for 11.7% of all parents who screened positive for depression.

Escitalopram Cuts MACE Risk in Depressed Patients With ACS

July 25, 2018

Higher risk of major adverse cardiac events with concurrent depression after acute coronary syndrome

FDA Fast-Tracks Novel Treatment for Major Depressive Disorder

By July 23, 2018

AGN-241751 is being developed in tandem with rapastinel, an investigational intravenous formulation of a novel NMDA receptor partial agonist, currently in Phase 3 development for MDD, as both a monotherapy and an adjunctive treatment.

Greening Vacant Land Improves Neighborhood Mental Health

July 23, 2018

A total of 110 clusters were randomly assigned to the greening intervention, the trash cleanup intervention (removal of trash, limited grass mowing, and regular monthly maintenance), or a control group.

Can Omega-3 Fatty Acid Monotherapy Effectively Treat Adolescent Depression?

July 20, 2018

These results challenge existing conceptions that omega-3 fatty acids may be effective in treating adolescent major depressive disorder.

Withdrawal Symptoms Following SNRI Discontinuation Investigated

By July 19, 2018

Results showed that discontinuation of any SNRI was associated with withdrawal symptoms, with the highest prevalence linked to venlafaxine and desvenlafaxine.

Physician Burnout Tied to Higher Risk of Medical Errors

July 17, 2018

Physicians reporting errors were more likely to also report burnout, fatigue, recent suicidal ideation

Treatment for Alzheimer-Related Agitation Gets Fast Track Status

By July 16, 2018

Currently, there are no approved treatments for behavioral symptoms (eg, aggression, agitation) in Alzheimer's disease.

Harmful Internet "Challenges" and Teens: A Guide for Primary Care Providers

July 12, 2018

Discussions involving Internet challenges with children and adolescents should be as sensitive as those about sexuality and drug or alcohol use.

FDA Strengthens Warnings for Fluoroquinolone Antibiotics

By July 10, 2018

The labeling changes are based on a review of postmarketing adverse event reports found in the FDA Adverse Event Reporting System (FAERS) database and published medical literature.

IT Solutions for Easier EHRs Save Physicians Time, Burnout

July 09, 2018

Three IT solutions are enabling Yale Medicine physicians to save hours of time. First, easier login identification, using badges to tap in and out of the EHR system throughout a shift, eliminates repetitive typing of the physician's username and password.

Efavirenz Use and Depression, Suicidal Ideation: Is There a Link?

June 26, 2018

The researchers found that depression or suicidal ideation did not differ at baseline for patients ever exposed to efavirenz versus those never exposed to efavirenz and receiving nevirapine.

Palliative Care Reduces Odds of Suicide in Lung Cancer Patients

June 22, 2018

Only 20% of the patients who died by suicide had a palliative care encounter, compared with 57% among lung cancer patients whose cause of death was not suicide.

Prenatal antidepressant exposure may increase risk of poor motor development

June 21, 2018

A meta-analysis of 18 studies examining the association of prenatal antidepressant exposure with motor development in children showed a small overall effect of worse motor development outcomes among children exposed to antidepressants in pregnancy.

Some Neonatal Risks for Lithium Exposure in Pregnancy

June 20, 2018

Compared with the reference group, lithium-exposed pregnancies had an increased risk for neonatal readmission (27.5 vs 14.3%; pooled adjusted odds ratio, 1.62).

Incidence of Extrapyramidal Symptoms Higher With Certain Antidepressants

By June 18, 2018

Within the cohort, 3838 cases were identified and compared with 38,380 age-matched controls.

Medications with depression as a possible adverse effect associated with increased risk

June 15, 2018

In this cross-sectional study, the use of medications with depression as an adverse effect was associated with a higher prevalence of depression while a similar association was not observed for medications without depression as a possible side effect.

AMA President Calls Physicians to Lead in Addressing Gun Violence

June 14, 2018

For decades the AMA has demonstrated leadership on this issue, recommending common-sense gun safety precautions, waiting periods and background checks for those wishing to purchase a gun, and increased mental health service funding.

Antipsychotic Tx Linked to Adiposity Changes in Youths

June 14, 2018

The researchers found that from baseline to week 12, the dual-energy X-ray absorptiometry percentage total body fat increased by 1.18, 4.12, and 1.66% for risperidone, olanzapine, and aripiprazole, respectively, and was significantly greater for olanzapine than risperidone or aripiprazole.

APA: Suicide Prevention Should Be a Public Health Priority

June 14, 2018

The APA is highlighting the need for more funding for evidence-based treatment and its dissemination, including crisis services, as well as more research focused on risk assessment, evidence-based prevention programs, and treatment to reduce the incidence of suicide.

Work Stress May Increase Risk of Developing Atrial Fibrillation

June 13, 2018

The researchers found that job strain was associated with an almost 50% increased risk of atrial fibrillation (hazard ratio [HR], 1.48; 95% confidence interval, 1.00 to 2.18) after adjustment for age, sex, and education.

Medications With Depression as Adverse Side Effect Commonly Used

June 13, 2018

The number of medications used with depression as a possible adverse effect correlated with increased prevalence of concurrent depression, in analyses excluding antidepressant users.

Suicide Rates On the Rise in Nearly Every State, Says New CDC Report

By June 08, 2018

Using data from the National Vital Statistics System, the CDC researchers examined trends in age-adjusted suicide rates in individuals 10 years of age and older, by state and sex, across 6 consecutive 3-year periods (1999-2016).

Prostate Cancer Treatment Side Effects Linked to Distress

June 08, 2018

This relationship was bidirectional, with men who reported worse distress also subsequently reporting worse urinary, bowel, and sexual functions.