Mood Disorders

Antidepressant Use for Insomnia: Is It Effective?

By May 16, 2018

For this study, researchers identified 23 randomized controlled trials that included a total of 2806 adults with a primary diagnosis of insomnia to examine the relationship between antidepressant use and insomnia treatment.

Children's hospital visits for suicide ideation and attempts are increasing

May 16, 2018

The percentage of patients seen at children's hospital for suicidal ideation (SI) and suicide attempts (SA) more than doubled between 2008 and 2015.

Suicide Ideation, Attempts Increasing Among US Children

May 16, 2018

The researchers identified 115,856 SI and SA encounters during the study period.

Disruption of Circadian Rhythm Negatively Impacts Mental Health

May 16, 2018

"Circadian disruption is reliably associated with various adverse mental health and well-being outcomes, including major depressive disorder and bipolar disorder," the authors write.

FDA Fast-Tracks Treatment for Autism Spectrum Disorder

By May 15, 2018

There are currently no approved pharmacological treatments that address these core symptoms of ASD.

ECT Effective for Treatment-Resistant Depression

May 15, 2018

ECT was projected to reduce time with uncontrolled depression from 50 to 33 to 37% of life-years over 4 years; greater improvements were seen when ECT was offered earlier.

Rates of Major Depression Up Among US Insured, Especially Youth

May 14, 2018

"The high rates for adolescents and millennials could have a substantial health impact for decades to come," Trent Haywood, MD, JD, the senior vice president and chief medical officer for the BCBS Association, said in a statement.

Treating Apathy in Alzheimer's Disease Patients: A Meta-Analysis

By May 11, 2018

Methylphenidate demonstrated an improvement in apathy vs placebo when measured by the apathy evaluation scale, in addition, methylphenidate showed possible improvement in cognition.

Lymphoma, Leukemia Survivors Have Increased Health Care Use

May 10, 2018

The researchers found that survivors of lymphoma and CLL contacted their general practitioner and medical specialist more often within the last year vs the control population.

Depressive Symptoms Tied to Memory, Aging of the Brain

May 10, 2018

With adjustment for sociodemographic, behavioral, and vascular risk factor variables, greater depressive symptoms were also associated with smaller cerebral parenchymal fraction (P=.02) and increased odds of subclinical brain infarcts (odds ratio, 1.55; P=.05).

Teen Sexting Linked to Intimate Partner Violence, Sexual Abuse

May 08, 2018

Independent correlations for having sent a sext were seen for having been sexually abused, IPV perpetration, ever had sex.

Positive Results Announced for Esketamine in Treatment-Resistant Depression

By May 07, 2018

In both studies, the primary efficacy endpoint was change from baseline to Day 28 in Montgomery-Åsberg Depression Rating Scale (MADRS) total score.

Executive Function Improved With Prenatal Exposure to SSRIs

May 07, 2018

The researchers found that even after controlling for MDS (prenatal and when child was age 12 years), maternal education, child's age, and verbal ability, children with pSRI performed better on the most demanding part of the Flanker/Reverse Flanker task.

Antidepressant Medications and Headache: Is There a Link?

By May 03, 2018

Compared to placebo, selective serotonin reuptake inhibitors (SSRIs) were associated with a significantly higher risk of headache (risk ratio [RR] 1.06, 95% CI: 1.00 to 1.13; P =.045).

Trintellix Labeling Updated With Data on Improved Processing Speed in MDD

By May 03, 2018

The approval was based on data from the 8-week, randomized, double-blind, placebo-controlled studies, FOCUS and CONNECT, which investigated the effect of Trintellix on various aspects of cognitive function among adults aged 18 to 65 years with depression.

Prevalence of ASD Estimated at 16.8 per 1,000 for 8-Year-Olds

April 30, 2018

In 2014, prevalence of autism spectrum disorder varied among sites and by sex and race/ethnicity

Anticholinergic Drug Use and Dementia: What's the Link?

By April 26, 2018

A total of 14,453 (35%) cases and 86,403 (30%) controls were prescribed at least 1 anticholingeric drug with an Anticholinergic Cognitive Burden (ACB) score of 3; 1429 (3.5%) cases and 7909 (2.8%) controls were prescribed drugs with an ACB score of 2; most patients (89% of cases and 87% of controls) received a drug with an ACB score of 1 during the drug exposure period (DEP).

People With Opioid Use Disorder Have High Suicide Rate

April 26, 2018

Based on data from the National Death Index and electronic health records, suicide risk was 87 per 100,000 among persons with OUD, 6 times that of people in the general US population. Efforts should be made to change opioid prescribing practices and to expand treatment for people with OUD.

FDA: Lamotrigine Linked to Potentially Life-Threatening Adverse Reaction

By April 25, 2018

Clinicians should conduct a medical evaluation as soon as suspicious symptoms are reported and discontinue lamotrigine if HLH is suspected.

ACOG: Revised Committee Opinion on Postpartum Care Released

By April 25, 2018

Previously, ACOG had recommended a comprehensive postpartum visit occur within the first 6 weeks after birth.

NDA Submitted for Postpartum Depression Treatment Brexanolone

By April 23, 2018

Results in the 202B and 202C trials showed that brexanolone achieved the primary endpoint of mean reduction from baseline in the Hamilton Rating Scale for Depression.

Grip Strength Indicative of Cognition in Major Depression

April 23, 2018

Handgrip strength was positively associated with improved visual memory, reaction time, prospective memory, and reasoning among individuals with bipolar disorder.

Questions Surround Concept of Internet Gaming Disorder

April 23, 2018

Definitions are heterogeneous; the proposed definition in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, provides a good starting point for diagnosing IGD, although there are some disadvantages.

Controversial New Research Changes the Narrative on Hans Asperger

By April 20, 2018

Medical records of 48 children examined by Asperger show that he specifically called for 12 of the children to be transferred to the Am Spieglegrund facility, the 'euthanasia' institution founded in 1940.

Time-Related Deployment Factors Predict Suicide Attempt Risk

April 19, 2018

The researchers found that the odds of SA during or after second deployment were increased among soldiers whose first deployment occurred within the first 12 months of service versus after 12 months and among those with a DT of 6 months or less versus longer than 6 months.

Esketamine Evaluated in MDD Patients at Imminent Risk for Suicide

By April 16, 2018

If approved, esketamine has the potential to be the first treatment for patients with major depressive disorder at imminent risk for suicide.

FDA to Review Opioid System Modulator for Major Depressive Disorder

By April 16, 2018

ALKS 5461 consists of a fixed-dose combination of buprenorphine, a partial mu-opioid receptor agonist and kappa-opioid receptor antagonist, and samidorphan, a mu-opioid receptor antagonist.

Non-Stigmatizing Messages Boost Mental Health Services Support

April 13, 2018

Participants were randomly allocated to a control arm or to read 1 of 3 narratives about SMI emphasizing violence, systemic barriers to treatment, or successful treatment and recovery.

Higher Mortality Risk Seen for 'Night Owls'

April 12, 2018

Data were included in the study for 433,268 adults aged 38 to 73 years at the time of enrollment, who were followed for an average of 6.5 years.

Higher Education, Depression, Pain Factors Associated With Opioid Misuse

April 10, 2018

However, only education, illicit drug use, depression, and pain interference with normal work were significant predictors of misuse.