Mood Disorders

Therapy Shows Significant Reduction in PTSD Symptoms

By October 20, 2017

Following completion of all treatments 12 (52%) of the 23 subjects who initially met PTSD Checklist-Military (PCL-M) for diagnosis no longer met the threshold criteria.

Licensure Concerns May Be a Barrier to Clinicians Seeking Mental Health Tx

By October 11, 2017

The survey revealed that almost 40% of physicians would be reluctant to seek formal medical care for treatment of a mental health condition due to perceived repercussions to their medical licensure.

Can Psychosocial Intervention Improve Antidepressants Adherence

September 28, 2017

"The Treatment Initiation and Participation Program is an effective intervention to improve early adherence to pharmacotherapy," the authors write. "Improved adherence can promote improvement in depression."

Antidepressant Overdose Risk Should Be Considered When Choosing Depression Tx

By September 26, 2017

Results showed that bupropion users were more likely to have a seizure, have accompanied tachycardia on presentation, and be admitted to the hospital, compared to those who ingested a TCA.

FDA Rejects Vraylar sNDA for Negative Symptoms of Schizophrenia

By September 25, 2017

In the letter the FDA stated that their preliminary appraisal found that the sNDA was not sufficiently complete to permit a substantive review.

Increased Med Use Over Time Seen in Older Patients of All BMI Classes

By September 22, 2017

Researchers aimed to determine whether the rise in prescription drug use over time varied by age and obesity status.

Asthma Drug Linked to Neuropsychiatric Adverse Events

By September 21, 2017

Results found that overall depression was the most commonly reported adverse event in the VigiBase group while headaches were the most frequent adverse event reported for the Dutch database.

Sleep Deprivation: An Effective Antidepressant?

By September 21, 2017

Researchers from the Perelman School of Medicine at the University of Pennsylvania analyzed 66 studies to determine the antidepressant effects of sleep deprivation.

Intranasal Ketamine Evaluated in Fear of Harm Bipolar Phenotype

By September 20, 2017

Findings showed that almost all patients were 'much' to 'very much' improved clinically and in ratings of social function and academic performance.

Depression Found to Be Independently Associated with Recurrent Chest Pain

By September 20, 2017

On multivariable regression models, depression was a significant independent predictor of 30-day chest pain recurrence after adjustment.

Lithium May Be Underused as Antisuicidal Agent, Review Finds

By September 19, 2017

Despite the abundance of evidence published in the past 40 years supporting lithium as an antisuicidal agent, its use is "underrepresented" and should be incorporated into clinical guidelines and practice more assertively.

Suicide Attempts Up; Particularly Evident Among Young Women

September 14, 2017

The researchers observed an increase in the weighted percentage of U.S. adults making a recent suicide attempt from 0.62% in 2004 to 2005 to 0.79% in 2012 to 2013 (risk difference adjusted for age, sex, and race/ethnicity [ARD], 0.17%).

Anxiety Disorders and Maternal, Fetal Outcomes Investigated

September 14, 2017

The researchers observed no correlation for panic disorder or GAD with maternal or neonatal complications of interest, in adjusted models.

Oral Tx for Acute Suicidal Ideation and Behavior Gets Fast Track Status

By September 06, 2017

Results from two previously Phase 2 trials of NeuroRx's sequential treatment have shown a 50% reduction in symptoms of depression and a 75% reduction in suicidal ideation in bipolar patients.

Drug-Dietary Supplement Interaction Leads to Surgical Emergency

By September 05, 2017

This case demonstrates how important it is for clinicians to be able to identify dietary supplements that can lead to dangerous drug-drug interactions.

FDA Greenlights MDMA Studies for Posttraumatic Stress Disorder

By August 31, 2017

"Our Phase 2 data was extremely promising with a large effect size, and we are ready to move forward quickly," said Amy Emerson, Executive Director of the MAPS Public Benefit Corporation.

Recall: Antipsychotic Tablets Found in Antidepressant Bottle

By August 29, 2017

A Health Hazard Evaluation indicated a high risk to the patient ingesting the foreign tablet.

Google Updating User Results to Help ID Depression

By August 24, 2017

The feature will take the form of a "Check if you're clinically depressed" button which will appear below the 'depression' panel that appears after the user's search.

Targeting Premenstrual Breakthrough of Depression with OCs: Is it Effective?

By August 18, 2017

Premenstrual exacerbation (PME) of depression has been found to occur in roughly two-thirds of women with depressive disorders.

CDC Report Outlines Antidepressant Use in the U.S. by Sex, Race

August 16, 2017

The researchers found that 12.7% of individuals (8.6% of males and 16.5% of females) took antidepressants in the past month during 2011 to 2014.

Cannabis Efficacy Examined in Patients with Chronic Pain, PTSD

August 15, 2017

The researchers found low-strength evidence that cannabis alleviates neuropathic pain based on 27 chronic pain trials; insufficient evidence was found in other pain populations.

Withdrawal Syndrome Following Online Purchase of 'Cognitive Enhancer'

By August 14, 2017

He was able to find an online health store that sold tianeptine and over three months continued to use the drug, increasing the dose on stressful days. During this time, he also began to experience withdrawal symptoms.

Recall: Antidepressant Tablets Found in Bottle Labeled for Cholesterol Med

By August 10, 2017

While side effects of bupropion are typically minor, some patients may be at greater risk for adverse effects.

Lithium, Divalproex Efficacy Examined in Older Bipolar Patients

By August 09, 2017

Results demonstrated that lithium was more effective in controlling manic signs and symptoms, as defined by a change from baseline Young Mania Rating Scale.

Neuroanatomic Abnormalities Identified in Those at High Risk for Autism

August 09, 2017

"In two genetically related cohorts at high risk for autism spectrum disorder, reciprocal neuroanatomic abnormalities were found and determined to be associated with cognitive and behavioral impairments," the authors write.

Does Aspirin Protect Against Symptoms of Depression?

By August 08, 2017

Research on whether aspirin (which has both anti-inflammatory and anti-atherosclerotic properties) has an impact on depression has been limited.

Vortioxetine Effectiveness Evaluated for Depression in Adults

By August 04, 2017

When compared to individual antidepressants, vortioxetine may be less effective than duloxetine in terms of response rates and depressive symptoms scores.

Neonatal Drug Withdrawal Risk Up with In Utero Exposure to Opioids, Psychotropics

August 03, 2017

The researchers observed variation in the absolute risk for neonatal drug withdrawal from 1.0 to 11.4% for infants exposed in utero to prescription opioids alone and opioids co-prescribed with gabapentin, respectively.

Study: Netflix Show Ups Suicide Awareness, But Also Suicidal Ideation

By July 31, 2017

Some of the searches were positive; 'suicide hotline' (up 12%) and 'suicide prevention' (up 23%), however there was a jump of 26% for the phrase 'how to commit suicide', and 'commit suicide' (up 18%), and 'how to kill yourself' (up 9%).

Abilify Maintena Gains New Bipolar I Disorder Indication

By July 28, 2017

The study's primary endpoint showed Abilify Maintena significantly delayed the time to recurrence of any mood episode in adults having a manic episode at screening vs. placebo.