MONODOX Rx

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MONODOX

Acne
Bacterial infections
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Generic Name and Formulations:

Doxycycline monohydrate 50mg, 100mg; caps.

Select therapeutic use:

Indications for MONODOX:

Adjunct in severe acne.

Adult:

200mg in 2–4 divided doses for 1 day, then 100mg/day in 1–2 doses. Reduce dose after improvement. Take with fluid.

Children:

Not applicable.

Warnings/Precautions:

Monitor blood, renal, and hepatic function in long-term use. Sunlight or UV light. Pregnancy (Cat.D), nursing mothers: not recommended.

Interactions:

May increase digoxin levels. Antacids, iron, zinc, calcium, magnesium reduce absorption. Avoid penicillins, methoxyflurane. Carbamazepine, hydantoins, barbiturates may decrease effectiveness. Monitor prothrombin time with oral anticoagulants. Oral contraceptives may be less effective.

Pharmacological Class:

Tetracycline antibiotic.

Adverse Reactions:

Photosensitivity, GI upset, rash, blood dyscrasias, hepatotoxicity.

How Supplied:

Caps 50mg—100; 100mg—50, 250

MONODOX 100mg capsules (Qty:60)

appx. price $1199.00

Indications for MONODOX:

Tetracycline-susceptible infections including respiratory, genitourinary, rickettsial, trachoma. Postexposure prophylaxis and treatment of anthrax.

Adult:

Take with fluids. 100mg every 12 hours for 1 day; then 100mg daily; max 200mg daily. Postexposure prophylaxis of inhalational anthrax, or treatment of cutaneous anthrax: 100mg orally every 12 hours (start as soon as possible after exposure). Treatment of inhalational, GI, or oropharyngeal anthrax, or cutaneous anthrax with systemic involvement, extensive edema, or head/neck lesions: use an IV form initially at 100mg IV every 12 hours (w. 1 or 2 other antimicrobials), then switch to oral form at 100mg every 12 hours. Treat for a total of 60 days.

Children:

<8 years: usually not recommended. ≥8 years (≤100lbs): 2mg/lb divided in 2 doses for 1 day; then 1–2mg/lb daily in 1–2 doses; max 2mg/lb daily. >100lbs: 100mg orally every 12 hours. Postexposure prophylaxis of inhalational anthrax, or treatment of cutaneous anthrax: >8 years (>45kg): as adult; >8 years (≤45kg) or ≤8 years: 2.2 mg/kg orally every 12 hours. Treatment of inhalational, GI, or oropharyngeal anthrax, or cutaneous anthrax with systemic involvement, extensive edema, or head/neck lesions: >8 years (>45kg): use an IV form first at 100mg every 12 hours (w. 1 or 2 other antimicrobials), then switch to oral form at same dose; >8 years (≤45kg) or ≤8 years: 2.2 mg/kg IV every 12 hours (w. 1 or 2 other antimicrobials), then switch to oral form at same dose. Treat for a total of 60 days.

Warnings/Precautions:

Monitor blood, renal, and liver function in long-term use. Sunlight or UV light. Pregnancy (Cat.D), nursing mothers: usually not recommended.

Interactions:

Antacids, iron, zinc, calcium, magnesium reduce absorption. Avoid concomitant methoxyflurane. Carbamazepine, phenytoin, barbiturates may decrease effectiveness. Monitor prothrombin time with oral anticoagulants.

Pharmacological Class:

Tetracycline antibiotic.

Adverse Reactions:

Photosensitivity, GI upset, rash, blood dyscrasias, hepatotoxicity.

Note:

See MMWR Vol 50, No.42 (Oct. 26, 2001) for more information on anthrax.

How Supplied:

Caps 50mg—100; 100mg—50, 250

MONODOX 100mg capsules (Qty:60)

appx. price $1199.00