Miscellaneous Urogenital Disorders

Nephrologist Follow-Up Frequency Examined Post-Severe AKI

October 16, 2017

Respondents were asked to rank their likelihood of recommending follow-up for each patient after hospital discharge.

Drug Combo Efficacy Examined for Patients with HCV and Kidney Disease

October 12, 2017

"Treatment with glecaprevir and pibrentasvir for 12 weeks resulted in a high rate of sustained virologic response in patients with stage 4 or 5 chronic kidney disease and HCV infection," the authors write.

Sleep Duration, Quality Tied to Chronic Kidney Disease Progression

September 15, 2017

Shorter sleep duration, greater sleep fragmentation linked to greater decline in eGFR

Biomarkers ID'd That May Enhance Prediction of Renal Function Decline

September 11, 2017

The researchers found in an eGFR trajectory analysis that 10.1% of participants were rapid decliners, with a mean decrease of 2.9 mL/min/1.73 m²/year.

Intensive Blood Pressure Control Linked to Increased CKD Risk

September 08, 2017

However, cardiovascular events, all-cause mortality risk decrease with intensive blood pressure lowering

Infection Risk Higher with Worsening Kidney Function

August 21, 2017

The study focused on infections that people develop in the community, not hospitals and other health care settings.

Novel lgA Nephropathy Tx Gains Orphan Drug Status

By August 11, 2017

Phase 2 trials have shown to be associated with reductions in urine protein levels following treatment with OMS721 in patients with lgA nephropathy.

Corticosteroid Safety Assessed in IgA Nephropathy

August 02, 2017

Recruitment was discontinued because of excess serious adverse events after randomization of 262 participants.

Vaccine for Recurrent UTI Granted Fast Track Designation

By July 26, 2017

The vaccine consists of the FimH bacterial adhesion protein as well as a new adjuvant designed to induce an immune response to prevent bacterial colonization of the urinary tract.

Testosterone Rx Behaviors Examined at Different Levels of Healthcare

July 24, 2017

"Our results highlight the opportunity to intervene both at the provider and the site level to improve testosterone prescribing," the authors write.

Blood Protein Found to Identify Chronic Kidney Disease Risk

June 28, 2017

The team found that elevated levels of the suPAR protein triggered the start and progression of chronic kidney disease in those with two copies of APOL1 gene variants.

New White Paper on Nonneurogenic Chronic Urinary Retention

June 20, 2017

The researchers note that nonneurogenic chronic urinary retention was defined by the workgroup as an elevated post-void residual of more than 300mL, which persisted for at least 6 months and was documented on at least 2separate occasions.

Empagliflozin to Be Investigated in Chronic Kidney Disease

By June 12, 2017

In addition, the companies are conducting other mechanistic studies that will evaluate the potential mechanisms by which empagliflozin may affect renal outcomes in patients with CKD.

Does Antioxidant Supplementation Slow Diabetic Kidney Disease Progression?

By June 02, 2017

Since oxidative stress is known to worsen DKD, study authors sought to review available data on the possible benefits of chronic antioxidant supplementation on DKD progression.

E-Cigarette Use May Up Bladder Cancer Risk

By May 15, 2017

The researchers believe that based on their findings, e-cigarette smokers may be at increased risk for bladder cancer.

AUA 'Choosing Wisely' List IDs Unnecessary Tests, Treatments

By May 15, 2017

The 2017 AUA list contains evidence-based recommendations to guide conversations between physicians and patients about what care is appropriate.

FDA Grants Vonapanitase Breakthrough Therapy Status for Hemodialysis Use

By May 10, 2017

A second Phase 3 trial for vonapanitase in hemodialysis patients, PATENCY-2, is currently ongoing and is expected to complete enrollment in the first quarter of 2018.

Dietary Intervention Outcomes Examined in Chronic Kidney Disease

By April 24, 2017

Based on these studies, it would appear that dietary changes could prevent 1 in every 3,000 people treated for 1 year avoid ESKD, however the certainty in this effect was very low.

Veltassa Efficacy Assessed When Taken Without Food

By April 21, 2017

Results showed that 87.3% of the Veltassa plus food group and 82.5% of the Veltassa and no food group achieved and maintained potassium levels in the target range.

Metabolic Outcomes in Trans Teens Receiving Cross-Sex Hormones

April 12, 2017

The researchers found that of the 72 subjects taking testosterone, at each visit significant increases in hemoglobin/hematocrit levels and BMI were recorded, as was a decrease in high-density lipoprotein level.

Environmental Toxins Linked to Multiple Diseases, Early Puberty

By April 07, 2017

These studies identified links to increased risks of thyroid, testicular and breast cancer, nonalcoholic fatty liver disease and even the early onset of puberty for boys, which can lead to diseases in adulthood.

Acute Kidney Injury Seen in Marathon Runners

March 29, 2017

Injury and repair biomarker levels suggest structural damage to renal tubules

Cutting Salt May Indirectly Help with Sleep Problems

March 27, 2017

An easy way for patients to reduce nighttime urination and subsequent impact on sleep

Orphan Drug Status Granted for C3 Glomerulopathy Treatment

By March 22, 2017

Patients with C3G experience progressive deterioration in renal function, ultimately leading to renal failure requiring dialysis and kidney transplant, if left untreated.

Emollient Use in Pediatric Atopic Dermatitis May Up Phthalate Levels

March 21, 2017

Children with frequent use of emollients generally had higher phthalate metabolite and paraben levels than uncommon users, reaching statistical significance for some LMW phthalates and parabens.

RRT Initiation Impacts Health-Related Quality of Life in ESRD

March 17, 2017

Total of 26.6 and 27 percent of patients experienced anxiety, depression with initiation of RRT

Adjunctive Therapy for Kidney Stone Management No Longer in Shortage

By March 13, 2017

Acetohydroxamic acid, which has proven a successful antibiotic treatment of urea-splitting Proteus infections after surgical removal of struvite stones, was in shortage since July 2014.

Clinicians Required to Register Patients Due to Nulojix Shortage

By March 07, 2017

The Food and Drug Administration (FDA) announced a shortage in the supply of Nulojix (belatacept; Bristol-Myers Squibb) due to an increase in demand for the drug exacerbated by a delay in transition to a more efficient manufacturing process.

Perrigo Approved for Generic Axiron Solution

By March 01, 2017

Perrigo has received final approval from the Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) for Testosterone Topical Solution, the generic version of Eli Lilly's Axiron Topical Solution.

Carbavance Gets Priority Review for Complicated UTI

By February 21, 2017

The study met the pre-specified primary endpoints and showed that treatment with Carbavance is associated with an overall success rate of 98.4%.