Miscellaneous Urogenital Disorders

Kidney Injury Incidence Following Non-Kidney Transplants Common in Children

January 09, 2018

The researchers assessed AKI in the first year after transplant and found that perioperative AKI (within the first week) occurred in 67% of children and that AKI after the first week occurred in 36%.

Emergency-Only Hemodialysis Tied to Higher-Mortality Rates

December 19, 2017

The mean 3-year relative hazard of mortality was increased for patients receiving emergency-only versus standard hemodialysis after adjustment for propensity score (hazard ratio, 4.96; 95% confidence interval, 0.93 to 26.45; P=0.06).

Antiretroviral Combination Linked to Increased CKD Risk

By December 08, 2017

The risk of chronic kidney disease (CKD) may be increased in patients living with HIV receiving tenofovir (TDF) with a ritonavir-boosted protease inhibitor compared to those who receive TDF with a non-nucleosidic reverse transcriptase inhibitor (NNRTI)

Possible New Marker of Kidney Disease Identified in Sickle Cell

December 05, 2017

Subsequently, 18 extracellular proteins were focused on, including CP, a protein involved in iron metabolism.

Does Sodium Bicarbonate Benefit Patients With Impaired Kidney Function Undergoing Angiography?

November 14, 2017

A total of 5,177 patients at high risk for renal complications were randomized and scheduled for angiography to receive intravenous sodium bicarbonate or sodium chloride and 5 days of oral acetylcysteine or placebo.

Sertraline May Not Benefit Non-Dialysis Dependent CKD Patients With MDD

November 07, 2017

The researchers found that there was a change in the 16-item Quick Inventory of Depression Symptomatology-Clinician Rated of −4.1 in the sertraline group and −4.2 in the placebo group.

Tolvaptan Slows Loss of Renal Function in Later-Stage ADPKD

November 06, 2017

Reduction in decline in eGFR for patients with later-stage autosomal dominant polycystic kidney disease

Uric Acid-Lowering Therapy May Improve Renal Outcomes in CKD Patients

By November 03, 2017

Uric acid-lowering therapy might improve kidney outcomes, including kidney failure events, proteinuria, and the rate of change in eGFR, and seem to reduce the risk of cardiovascular events in adults with CKD.

Regular Coffee Consumption May Aid Chronic Kidney Disease Patients

November 03, 2017

Compared with individuals in the first quartile of caffeine consumption, those in the second, third, and fourth quartiles had adjusted hazard ratios for mortality of 0.88.

Nutritional Interventions Could Benefit Chronic Kidney Disease

November 02, 2017

Dietary interventions may be used for conservative uremia management and to delay or prevent dialysis therapy, say the authors of the review.

Nephrologist Follow-Up Frequency Examined Post-Severe AKI

October 16, 2017

Respondents were asked to rank their likelihood of recommending follow-up for each patient after hospital discharge.

Drug Combo Efficacy Examined for Patients with HCV and Kidney Disease

October 12, 2017

"Treatment with glecaprevir and pibrentasvir for 12 weeks resulted in a high rate of sustained virologic response in patients with stage 4 or 5 chronic kidney disease and HCV infection," the authors write.

Sleep Duration, Quality Tied to Chronic Kidney Disease Progression

September 15, 2017

Shorter sleep duration, greater sleep fragmentation linked to greater decline in eGFR

Biomarkers ID'd That May Enhance Prediction of Renal Function Decline

September 11, 2017

The researchers found in an eGFR trajectory analysis that 10.1% of participants were rapid decliners, with a mean decrease of 2.9 mL/min/1.73 m²/year.

Intensive Blood Pressure Control Linked to Increased CKD Risk

September 08, 2017

However, cardiovascular events, all-cause mortality risk decrease with intensive blood pressure lowering

Infection Risk Higher with Worsening Kidney Function

August 21, 2017

The study focused on infections that people develop in the community, not hospitals and other health care settings.

Novel lgA Nephropathy Tx Gains Orphan Drug Status

By August 11, 2017

Phase 2 trials have shown to be associated with reductions in urine protein levels following treatment with OMS721 in patients with lgA nephropathy.

Corticosteroid Safety Assessed in IgA Nephropathy

August 02, 2017

Recruitment was discontinued because of excess serious adverse events after randomization of 262 participants.

Vaccine for Recurrent UTI Granted Fast Track Designation

By July 26, 2017

The vaccine consists of the FimH bacterial adhesion protein as well as a new adjuvant designed to induce an immune response to prevent bacterial colonization of the urinary tract.

Testosterone Rx Behaviors Examined at Different Levels of Healthcare

July 24, 2017

"Our results highlight the opportunity to intervene both at the provider and the site level to improve testosterone prescribing," the authors write.

Blood Protein Found to Identify Chronic Kidney Disease Risk

June 28, 2017

The team found that elevated levels of the suPAR protein triggered the start and progression of chronic kidney disease in those with two copies of APOL1 gene variants.

New White Paper on Nonneurogenic Chronic Urinary Retention

June 20, 2017

The researchers note that nonneurogenic chronic urinary retention was defined by the workgroup as an elevated post-void residual of more than 300mL, which persisted for at least 6 months and was documented on at least 2separate occasions.

Empagliflozin to Be Investigated in Chronic Kidney Disease

By June 12, 2017

In addition, the companies are conducting other mechanistic studies that will evaluate the potential mechanisms by which empagliflozin may affect renal outcomes in patients with CKD.

Does Antioxidant Supplementation Slow Diabetic Kidney Disease Progression?

By June 02, 2017

Since oxidative stress is known to worsen DKD, study authors sought to review available data on the possible benefits of chronic antioxidant supplementation on DKD progression.

E-Cigarette Use May Up Bladder Cancer Risk

By May 15, 2017

The researchers believe that based on their findings, e-cigarette smokers may be at increased risk for bladder cancer.

AUA 'Choosing Wisely' List IDs Unnecessary Tests, Treatments

By May 15, 2017

The 2017 AUA list contains evidence-based recommendations to guide conversations between physicians and patients about what care is appropriate.

FDA Grants Vonapanitase Breakthrough Therapy Status for Hemodialysis Use

By May 10, 2017

A second Phase 3 trial for vonapanitase in hemodialysis patients, PATENCY-2, is currently ongoing and is expected to complete enrollment in the first quarter of 2018.

Dietary Intervention Outcomes Examined in Chronic Kidney Disease

By April 24, 2017

Based on these studies, it would appear that dietary changes could prevent 1 in every 3,000 people treated for 1 year avoid ESKD, however the certainty in this effect was very low.

Veltassa Efficacy Assessed When Taken Without Food

By April 21, 2017

Results showed that 87.3% of the Veltassa plus food group and 82.5% of the Veltassa and no food group achieved and maintained potassium levels in the target range.

Metabolic Outcomes in Trans Teens Receiving Cross-Sex Hormones

April 12, 2017

The researchers found that of the 72 subjects taking testosterone, at each visit significant increases in hemoglobin/hematocrit levels and BMI were recorded, as was a decrease in high-density lipoprotein level.