Miscellaneous Respiratory Disorders

Nintedanib Fast Tracked for ILD-Associated Scleroderma

By March 19, 2018

The designation was supported by the Investigational New Drug application (IND) for the treatment of SSc-ILD and the anticipated safety and efficacy data from the Phase 3 double-blind, randomized, placebo-controlled SENSCIS trial.

Cluster of Idiopathic Pulmonary Fibrosis Cases ID'd Among Dentists

By March 14, 2018

Some substances used while conducting these tasks contained silica, polyvinyl siloxane, alginate, and other compounds with known or potential respiratory toxicity.

Pediatric Airflow Obstruction and Tobacco Smoke Exposure: Is There a Link?

March 09, 2018

Serum cotinine level was not significantly associated with airflow obstruction in the multivariate analysis with both exposures included as covariates (adjusted odds ratio, 1.07; 95% confidence interval, 0.94 to 1.21); there was no correlation in children with asthma or those without asthma.

FDA Accepts Solriamfetol NDA for Narcolepsy-, OSA-Related Sleepiness

By March 02, 2018

Solriamfetol is a selective dopamine and norepinephrine reuptake inhibitor.

Undergoing Cardiac Sx During Flu Season May Increase Respiratory Disease Odds

February 22, 2018

Researchers found that ARDS developed in 5.1% of the 740 patients who were admitted to the intensive care unit after cardiac surgery during baseline periods. ARDS developed in 5.6% of the 984 patients in the periods between baseline and influenza seasons and in 9% of the 289 patients during influenza seasons.

Cleaning Could Impact Respiratory Health

February 21, 2018

The researchers found that forced expiratory volume in 1 second (FEV1) declined more rapidly in women responsible for cleaning at home and occupational cleaners compared to women not engaged in cleaning.

Study Reveals Factors Linked to Inappropriate Antibiotic Prescribing

February 05, 2018

Adult patients seen by an advanced practice practitioner were 15% more likely to receive an antimicrobial compared to those seen by a physician provider, after adjustment.

Greater rates of mortality linked to infants at risk for maltreatment

January 29, 2018

Infants classified as very high risk for substantiated maltreatment had a higher relative risk of overall mortality, death through unintentional and inflicted injury, and sudden unexpected infant death.

Pre-Op Physical Therapy May Cut Pulmonary Complications

January 29, 2018

The absolute risk reduction was 15%, with the number needed to treat of 7

Forceful Sneeze Leads to Rare, but Serious Injury

By January 17, 2018

The man explained how he suppressed a sneeze by pinching his nostrils and keeping his mouth closed, and then felt a popping sensation in his neck.

Detection of respiratory viruses in febrile infants suggests lower risk of bacterial infection

January 17, 2018

Respiratory viruses were identified in 55% of febrile infants; those older than 28 days had a lower risk of bacterial infection when they tested positive for a respiratory virus.

Serial In-Office Intralesional Steroids May Aid Tracheal Stenosis Sx

January 12, 2018

Patients were followed for a mean of 32.3 months and underwent a mean of 4.08 injections. The researchers found that after ISI, 71% of the patients did not undergo further surgery.

No long-term neurodevelopmental effects of inhaled budesonide in preterm infants

January 11, 2018

Budesonide used for prevention of bronchopulmonary dysplasia in extremely preterm infants showed no difference in rate of neurodevelopmental disability at two years compared to placebo treated infants.

Vitamin D<sub>3</sub> Supplementation Examined for Aterial Stiffness Amelioration

January 10, 2018

The researchers observed a dose-response increase in serum 25(OH)D concentrations between the groups with vitamin D3 supplementation.

CDC: Unsafe Infant Sleep Practices Still Prevalent

January 10, 2018

The researchers found that 21.6% of respondents from 32 states and New York City reported placing their infant in a non-supine sleep position in 2015.

Lung Cancer Screening: Risk-Based Versus USPSTF Criteria Compared

January 04, 2018

Risk targeting may improve screening efficiency, but gains attenuated in terms of QALYs, cost

Higher Fruit Intake May Delay Lung Function Decline, Especially in Ex-Smokers

December 26, 2017

Apple, banana, tomato intake linked to slower decline in forced vital capacity in ex-smokers

Broad-Spectrum Antibiotics No Better Than Narrow-Spectrum for Kids With Acute RTI

December 20, 2017

The researchers found that 14% of the children in the retrospective cohort study were prescribed broad-spectrum antibiotics.

Additional Recommendations for LAM Diagnosis and Management Issued

November 29, 2017

The researchers made conditional recommendations against making a clinical diagnosis of LAM for women who have cystic changes on high-resolution computed tomography of the chest characteristic of LAM, but who have no additional confirmatory features of LAM.

AASM: Position Statement on Home Sleep Apnea Testing

By October 16, 2017

HSATs are ordered by healthcare providers to help diagnosis obstructive sleep apnea (OSA) in adults.

Standard Guidelines Needed for Pulmonary Fibrosis Assessment Test

October 13, 2017

Development of nuanced standards designed specifically for IPF are needed given that there is increasing evidence and experience with its use in clinical trials.

Removing Behavioral Interventions May Up Inappropriate Antibiotic Prescribing

October 11, 2017

The researchers found that the rate of inappropriate antibiotic prescribing decreased in control clinics from 14.2 to 11.8% during the post-intervention period (absolute difference, −2.4%).

New Implant Approved for Moderate to Severe Central Sleep Apnea

By October 10, 2017

The implantable device works by stimulating a nerve in the chest that is involved in transmitting signals to the diaphragm to stimulate breathing.

Linhaliq NDA Granted Priority Review

By September 25, 2017

Linhaliq was previously granted Qualified Infectious Disease Product (QIDP) Designation and Fast Track designation for NCFBE with lung infections with P. aeruginosa.

Impact of CPAP Telemonitoring with Feedback on Adherence

September 19, 2017

"The use of CPAP telemonitoring with automated feedback messaging improved 90-day adherence in OSA patients," the authors wrote.

Race May Play Role in Antibiotic Rx Trends for Pediatric ARTI

September 06, 2017

The researchers found that 2.6% of the PED encounters for viral ARTIs resulted in patient receipt of antibiotics, including 4.3, 1.9, 2.6, and 2.9% of non-Hispanic white, non-Hispanic black, Hispanic, and other non-Hispanic children, respectively.

Regeneron to Discontinue Development of RSV Treatment

By August 14, 2017

The primary endpoint of RSV prevention - assessed through day 150 of treatment - was not significantly reached.

NDA Submitted for Non-Cystic Fibrosis Bronchiectasis Treatment

By August 11, 2017

Linhaliq (previously known as 'Pulmaquin') consists of a mixture of liposome encapsulated and unencapsulated ciprofloxacin. Linhaliq has previously been granted Orphan Drug status for the management of bronchiectasis.

Guaifenesin/Pseudoephedrine Intervention May Cut Antibiotic Rxs for Acute URTI

By August 03, 2017

Results found that at day 8 of the study, a significantly lower amount of patients receiving guaifenesin/pseudoephedrine desired antibiotics compared to placebo, 4.2% vs. 8.0%, respectively.

'Overfat' Pandemic Grows Even as Obesity Rates Level Off

July 25, 2017

Traditional methods of measuring weight or body mass index are ineffective in assessing whether a person is overfat, the study authors said.