Miscellaneous Ocular Agents

First Gene Tx for Inherited Retinal Disease Gets Thumbs Up from FDA Committee

By October 13, 2017

The recommendation was based on data from the Luxturna clinical development program which included a Phase 3 trial in patients 4-44 years of age.

Do Electronic Health Records Present Increased Burden on Ophthalmologists?

October 13, 2017

The researchers found that the mean total ophthalmologist examination time was 11.2 minutes per patient, of which 27% was spent on EHR use, 42% on conversation, and 31% on examination.

Combo Verteporfin Tx Assessed in Polypoidal Choroidal Vasculopathy

October 10, 2017

Mean improvement at 12 months was 8.3 letters with combination therapy compared with 5.1 letters with monotherapy, demonstrating that combination therapy met the predefined criterion for noninferiority as well as being superior to monotherapy.

Infection Risk Investigated for Processed Tissue in Corneal Transplants

October 02, 2017

The researchers found that donor rim culture results were three times more likely to be positive for fungi in endothelial keratoplasty-processed eyes (1.14%) compared with other uses (0.37%).

Dietary Supplement Examined for Effects on Macular Pigment Density

September 29, 2017

The researchers found that there was a statistically significant increase in plasma lutein and zeaxanthin in the lutein plus zeaxanthin group after 3 months and 6 months of treatment versus the placebo group

Zika Associated with Similar Retinal Problems as Cobalamin C Deficiency

September 08, 2017

In 7 of 8 eyes with a normal photoreceptor layer, pericentral retina with normal lamination showed a thinned (<30% of normal thickness) ganglion cell layer (GCL) that colocalized.

USPSTF Issues Vision Screening Recommendation for Children

September 06, 2017

The USPSTF concluded that the overall net benefit is moderate for children aged 3 to 5 years (B recommendation).

Over-the-Counter Tx May Slow Age-Related Macular Degeneration

August 25, 2017

The investigators found that both formulations were cost-effective for treating patients with early-stage disease, but they were even more cost-effective for those with the condition in only 1 eye.

The Dos and Don'ts of Viewing a Solar Eclipse

By August 18, 2017

The moon passes the sun so quickly (at 2880km/h) that most of the time individuals (even those in the direct path of totality) will be experiencing a partial eclipse, and will be exposed to the sun's core.

FDA: Vision Impairment, Other Serious Side Effects Tied to Compounded Injectable

By July 31, 2017

The triamcinolone and moxifloxacin injection was intended for use as post-op prophylaxis for ocular inflammation and endophthalmitis to eliminate the use of post-op eye drops.

Eye Exams Should Be Requirement for Infants Potentially Exposed to Zika

July 18, 2017

One in 5 of the infants had sight-threatening eye abnormalities, with optic nerve and retinal abnormalities the most common.

Early Biomarker May Help Differentiate Parkinsonism Disorders

July 12, 2017

Magnetic resonance imaging (T1-weighted and diffusion-weighted imaging) with a 3-T magnetic resonance imager revealed that the Parkinson's patients had significant alterations in optic radiation connectivity distribution.

NDA Accepted for Anti-Inflammatory Inj Post-Cataract Surgery

By June 26, 2017

Dexycu injection was developed to help compliance—especially among elderly patients—and avoid dosing errors associated with conventional treatments that depend on self-administered eye drops multiple times a day.

Can Dietary Vitamin K Protect Against Cataracts?

May 22, 2017

After adjustment for potential confounders, the risk of cataracts was lower among participants in the highest versus the lowest tertile of dietary vitamin K1 intake (hazard ratio, 0.71).

Implant Compared to Systemic Anti-inflammatory Therapy for Treating Uveitis

May 08, 2017

In seven-year follow-up, visual acuity better than with intravitreous fluocinolone acetonide implants

Novel Therapy Shows Potential in Thyroid-Associated Ophthalmopathy

May 04, 2017

The researchers found that in the intention-to-treat population, 69 and 20% of those who received teprotumumab and placebo, respectively, had a response at week 24.

Anti-VEGF Treatments Examined for Effects on Diabetic Retinopathy

April 28, 2017

Researchers conducted a secondary analysis of data from a comparative effectiveness trial for center-involved DME in 650 participants during 2 years of treatment with aflibercept (2mg), bevacizumab (1.25mg), or ranibizumab (0.3mg).

Treatment Combo Shows Promise for JIA-Associated Uveitis

April 27, 2017

Children with active JIA-associated uveitis who were taking a stable dose of methotrexate were randomly assigned to either adalimumab or placebo for 2 weeks.

Novel Therapy Shows Promise in Retinitis Pigmentosa

April 25, 2017

The researchers observed an increase in cone-like cells after switching rod to cone-like photoreceptors in situ by inactivation of Nrl or Nr2e3.

FDA Approves Treatment for All Forms of Diabetic Retinopathy

By April 17, 2017

The analysis indicated that patients with and without DME in the Lucentis treatment group had improvements in the severity of their retinopathy.

Recreational 'Poppers' Linked to Blurriness and Blind Spots

April 12, 2017

The 6 products with isopropyl nitrite were associated with visual problems while the 2 without were not.

Cardio-, Cerebrovascular Safety of Ranibizumab in DME Evaluated

April 10, 2017

The researchers assessed the cardiovascular and cerebrovascular safety of ranibizumab 0.3mg and 0.5mg vs. sham with and without laser in diabetic macular edema.

Impact of Age-Related Macular Degeneration May Differ by Ethnicity

March 31, 2017

The researchers found that early AMD was associated with a small reduction in VSF compared with no AMD in adjusted models in a group of ethnic Chinese but not in groups of ethnic Indians or Malays.

Implantable Artificial Retina in the Works

By March 29, 2017

The finished product is still some way off being consumer-ready, but when complete it could restore sight to millions of people with degenerative eye diseases.

Tocilizumab Assessed for JIA-Associated Uveitis

March 17, 2017

Rapid and maintained improvement in all ocular parameters was seen with tocilizumab treatment.

Stem Cell Therapy for AMD Appears Beneficial but Risky

March 16, 2017

One report warns of severe visual loss after macular degeneration treatment in 'trial'

USPSTF: Amblyopia Screening Should Occur Before Age 5

March 01, 2017

Young children should be screened at least once for amblyopia before they turn 5 years old, according to a draft recommendation statement issued by the U.S. Preventive Services Task Force.

NDA Re-Submitted for Novel Glaucoma Drug

By February 27, 2017

Valeant have re-submitted their NDA for latanoprostene bunod ophthalmic solution after receiving a Complete Response Letter from the FDA last summer.

Dextenza NDA Resubmission Accepted for Post-Surgical Ocular Pain

By February 23, 2017

The NDA for Dextenza was resubmitted in January 2017 following a Complete Response Letter that was issued in July 2016 due to concerns with deficiencies in manufacturing processes and controls.

ADA: Diabetic Retinopathy Management Guidelines Issued

By February 22, 2017

To reduce the risk or slow the progression of of diabetic retinopathy, the guidelines recommend optimizing glycemic control, as well as lowering blood pressure and serum lipids.