Miscellaneous Ob/Gyn Conditions

Prenatal Falling Insulin Requirement Linked to Complications

August 16, 2017

The researchers found that FIR ≥15% correlated with an increased risk of the composite primary outcome (odds ratio, 4.38) and preeclampsia (odds ratio, 6.76), and was more common among women with type 1 diabetes (36.6 versus 14.5%)

Smoking Up Among Some Populations During Pregnancy

August 15, 2017

Over the study period, smoking during pregnancy increased significantly among women with MDE (35.9 to 38.4%; P=0.02), while a decreasing trend among women without MDE only approached statistical significance (12.5 to 9.1%; P=0.07).

Cancer Rates Assessed Post-Endometrial Ablation

August 14, 2017

Leiomyomas, age younger than 35 years, at least 2 prior cesarean deliveries, and history of sterilization were factors that predisposed patients to post-ablation hysterectomy.

HIV Viral Load Rebound Observed After Suppression in Pregnancy

August 14, 2017

The researchers found that 318 of the 470 women in the database met inclusion criteria. Nineteen women (6%) had viral load rebound with a mean log10 viral load near delivery of 2.71 copies/mL (=513 copies/mL), while 6 women (32%) had a viral load above 1,000 copies/mL.

Neonate Antibody Response Examined After Maternal Flu Vaccination

August 04, 2017

The researchers found that, compared to the 50 women with no vaccination in the previous year, the 91 women vaccinated the prior year exhibited higher baseline antibody titers and/or seroprotection rates against all four influenza strains, after controlling for covariates.

Neonatal Drug Withdrawal Risk Up with In Utero Exposure to Opioids, Psychotropics

August 03, 2017

The researchers observed variation in the absolute risk for neonatal drug withdrawal from 1.0 to 11.4% for infants exposed in utero to prescription opioids alone and opioids co-prescribed with gabapentin, respectively.

ACOG Issues Guidance for Pregnancies Affected by Substance Abuse

July 28, 2017

The authors noted that there may be a select group of women who make an informed choice of medically supervised withdrawal, which should be under the care of an experienced physician and include long-term follow-up and support to help prevent relapse.

Diet, Physical Activity During Pregnancy May Influence C-Section Risk

July 21, 2017

The researchers found that, overall, interventions were associated with a 9% reduction in risk of cesarean section, and a 24% reduction in risk of developing gestational diabetes.

Maternal Antidepressant Use May Contribute to Offspring Autism

July 21, 2017

"Importantly, the absolute risk of autism was small, and, hypothetically, if no pregnant women took antidepressants, the number of cases that could potentially be prevented would be small," wrote the authors of the study.

Ob-Gyn Shortage Possible in Some Parts of the U.S., Says New Report

By July 20, 2017

Commenting on the report, retired Ob-Gyn Valerie Anne Jones, MD said, "Access to maternity care and women's health services is vitally important, and we need to have infrastructure to support the numbers or these women will have no Ob-Gyn to turn to despite having insurance."

Antibiotics During Pregnancy and Birth Defects: What's the Link?

By July 19, 2017

The data showed in utero exposure to clindamycin was associated with a higher risk of MCMs (adjusted odds ratio [aOR] 1.34, 95% CI: 1.02-1.77), musculoskeletal system malformations (aOR 1.67, 95% CI: 1.12-2.48), and ventricular/atrial septal defect (aOR 1.81, 95% CI: 1.04-3.16).

Maternal Antidepressant Use and Offspring Disability: What's the Link?

July 13, 2017

No significant association for use of antidepressant in pregnancy, child's intellectual disability

Sugary Drink Consumption During Pregnancy Tied to Adiposity in Offspring

July 11, 2017

The team found that higher sugar-sweetened beverage intake during the second trimester of pregnancy was associated with greater adiposity in mid-childhood.

Maternal Ingestion of Placenta Capsules Linked to Bacteremia in Infant

By July 06, 2017

While the clinicians could not rule out the possibility of transmission from a colonized household member, their final diagnosis was late-onset GBS disease attributable to high maternal colonization secondary to consumption of GBS-infected placental tissue.

CDC: Teen Birth Rates Reach Record Low

July 05, 2017

CDC researchers used birth records for nearly 100% of the births in the United States in 2016. The teen birth rate was 20.3 births per 1,000 female teens in 2016, compared to 41.5 births per 1,000 in 2007, according to the report.

Acupuncture Examined in Incontinence, Infertility

June 28, 2017

"The use of acupuncture with or without clomiphene, compared with control acupuncture and placebo, did not increase live births," the authors write.

Severe, Monthly Hypertensive Episodes in a Female Patient

By June 26, 2017

The patient was a 32-year-old nulliparous white female who reported a 5-year history of severe hypertension, hypokalemia, and resultant systolic dysfunction.

Fetal Demise, Preterm Birth High in Diabetic Ketoacidosis

June 21, 2017

The researchers found that fetal demise, preterm birth, and neonatal intensive care unit (NICU) admissions occurred in 15.6, 46.3, and 59% of pregnancies, respectively.

NAS Proving to be 'Enormous' Burden for Hospitals

June 16, 2017

By 2012, neonatal abstinence syndrome was costing the United States nearly $316 million in hospital care — up from $61 million in 2003.

Maternal Excess Weight Tied to Higher Risk of Birth Defects

June 16, 2017

The risk of birth defects rose to 3.5% among overweight women with a body mass index (BMI) of 25 to <30 kg/m².

Risks Associated with Lithium Use in Pregnancy Reevaluated

June 09, 2017

The study included information on 1,325,563 women enrolled in Medicaid. They gave birth between 2000 and 2010.

Ideal Magnesium Sulfate Dose ID'd for Fetal Neuroprotection

By June 07, 2017

The analysis found that the simulated maternal serum concentration associated with the lowest probability of infant cerebral palsy was 4.1mg/dL, while the simulated total administered magnesium dose associated with the lowest probability of delivering an infant with cerebral palsy was 64g.

Medical Abortion via Online Telemedicine: Outcomes Explored

By May 17, 2017

The study was conducted in 1,000 women residing in the Republic of Ireland and Northern Ireland, where abortion is not available through the formal healthcare system.

Significant Improvements in Sexual Function Seen with Flibanserin

May 16, 2017

Patients noted improvements in desire, arousal, lubrication, orgasm, satisfaction, and pain.

Domperidone Should Not Be Used for Lactation Enhancement

May 15, 2017

Limited quality evidence is available for the effectiveness of domperidone in enhancement of lactation, while considerable evidence is available on the cardiac risks associated with domperidone, which include QT prolongation, torsades de pointes, and sudden cardiac death.

Gestational Diabetes Biomarker Identified

May 11, 2017

Plasma glycated CD59 measurement at 24 to 28 weeks can identify women with failed GCT, GDM

FDA Issues Complete Response Letter for Dyspareunia Drug

By May 09, 2017

The FDA has issued a Complete Response Letter (CRL) to the New Drug Application (NDA) of TX-004HR (TherapeuticsMD) for the treatment of moderate-to-severe vaginal pain during sexual intercourse (dyspareunia), a symptom of vulvar and vaginal atrophy (VVA) due to menopause.

Effects of Breastfeeding Examined On Offspring Gut Health

May 09, 2017

The investigators found that 27.7% of beneficial bacteria in a baby's intestinal tract come directly from the mother's milk, and 10.3% comes from areolar skin.

pH-Balanced Vaginal Gel Assessed for Dyspareunia in Breast CA Survivors

April 10, 2017

The researchers found that both groups experienced a significant improvement of dyspareunia, with no difference between the groups.

Prenatal Progesterone Exposure May Affect Offspring Sexual Orientation

By April 06, 2017

"The findings highlight the likelihood that prenatal exposure to progesterone may have a long-term influence on behavior related to sexuality in humans," said lead researcher June Reinisch, Director Emerita of The Kinsey Institute.