Miscellaneous Neurodegenerative Disorders

Cervical Dystonia Drug Candidate Gets Orphan Drug Designation

By November 21, 2017

Treatments for cervical dystonia include oral medications, botulinum toxin injections, surgery, and complementary therapies.

Early cART, Viral Suppression May Minimize Brain Injury in HIV Patients

November 15, 2017

No significant neuropsychological decline during two-year period with combination antiretroviral therapy

Long-Term Effects of Valbenazine Examined in Adults With Tardive Dyskinesia

By November 14, 2017

Maintenance of treatment effect was demonstrated with both doses.

Previous West Nile Infection Linked to Neurologic Abnormalities

November 09, 2017

Data were included for 262 patients with a history of WNV enrolled in a longitudinal cohort from 2002 to 2012; 117 patients underwent neurologic and neurocognitive evaluations.

Nusinersen Beneficial in Infantile-Onset Spinal Muscular Atrophy

November 02, 2017

In additiona, a gene replacement therapy was found to be beneficial in spinal muscular atrophy type 1 (SMA1).

Hypothermia Tx Outcomes Examined for Newborns With Encephalopathy

October 26, 2017

The researchers found that the composite outcome of death or moderate to severe disability at 18 to 22 months occurred in 19 of 78 (24.4%) hypothermic infants and 22 of 79 (27.9%) noncooled infants.

Valbenazine Granted Orphan Drug Designation for Tourette Syndrome

By October 25, 2017

Valbenazine is already approved and marketed as Ingrezza in the US to treat adults with tardive dyskinesia

Soliris Approved to Treat Generalized Myasthenia Gravis

By October 24, 2017

The FDA based its approval of the extended indication for Soliris on comprehensive clinical data from the Phase 3, randomized, double-blind, placebo-controlled, multicenter REGAIN study (ECU-MG-301).

Better Risk Factor Modification Strategies Needed for Optimal Stroke Prevention

October 12, 2017

Increases in prevalence of hypertension, diabetes, dyslipidemia, smoking, and drug abuse in AIS

FDA Approves New Dosage Strength for Ingrezza

By October 05, 2017

The 80mg capsule is expected to be available in 30-count bottles within the next two weeks.

Movement Disorder Symptoms Found to Diminish with Alcohol Intake

September 22, 2017

The researchers found that patients showed a significantly reduced number of conditioned eyeblink responses before alcohol administration versus controls.

Adverse Effects Compared for Multiple Parkinson's Disease Drugs

September 21, 2017

The researchers found that, compared with placebo, the incidence of adverse reactions of ropinirole, rotigotine, entacapone, and sumanirole were higher in terms of nausea.

Mineral Level May Impact Dementia Risk

September 21, 2017

Researchers found an increased risk of dementia associated with both low serum magnesium levels (≤0.79 mmol/L) and high serum magnesium levels (≥0.90 mmol/L).

New Nymalize Ready-to-Use Dosing Option Available

By September 20, 2017

This new option is intended for patients who need a dosage lower than the standard 20mL (60mg) dose.

Link Between Cardiovascular Med Use and Cognitive Impairment Explored

September 01, 2017

No link for impaired cognition, antihypertensive, antithrombotic, lipid-modifying agent use

Does Adding Evolocumab to Statin Tx Impact Cognitive Function?

August 17, 2017

The researchers found that the mean change from baseline over time in the raw score for the spatial working memory strategy index of executive function was −0.21 ± 2.62 and −0.29 ± 2.81 in the evolocumab and placebo groups, respectively.

Study Reveals Diverse Neurologic Complications with Zika Virus

August 15, 2017

Forty patients were enrolled, including 29 with Guillain-Barré syndrome (GBS), 7 with encephalitis, 3 with transverse myelitis, and 1 with newly diagnosed chronic inflammatory demyelinating polyneuropathy. Diverse Spectrum of Neurologic Syndromes Seen With Zika

'Groundbreaking' Technology Heals Serious Injuries with a Single Touch

By August 09, 2017

"By using our novel nanochip technology, injured or compromised organs can be replaced. We have shown that skin is a fertile land where we can grow the elements of any organ that is declining," said Dr. Chandan Sen.

Radicava Now Available for the Treatment of ALS

By August 08, 2017

Radicava is supplied as a 30mg/100mL solution for intravenous infusion in single-dose polypropylene bags.

Memantine Started Quickly After TBI May Reduce Levels of Brain Damage Biomarker

By August 04, 2017

Before study initiation, NSE levels were similar for both groups. On Day 3 of the study, the NSE levels were 7.95 ± 2.86 ng/mL for the memantine group and 12.33 ± 7.09 ng/mL for the control group (P=0.05).

Fluoroquinolones May Up Risk of PTCS, a Rare But Serious Condition

By August 01, 2017

For this study, the researchers examined data from the LifeLink Database for cases with ICD-9-CM code for benign intracranial hypertension (BIH) as well as an MRI or CT scan and a lumbar puncture within 15 or 30 days of the BIH code.

Dementia Risk Up in Older Patients with Hearing Loss

July 31, 2017

The researchers found that in cross-sectional analyses, participants with self-reported or objective moderate and poor hearing were more likely to have a dementia diagnosis than those with normal hearing, after adjustment for potential confounders.

Demystifying Conversion Disorder: A Guide for Primary Care Clinicians

By July 26, 2017

Assessing conversion disorder and distinguishing it from other conditions can be challenging.

CTE Identified in Nearly All Donated Brains from NFL Players

July 26, 2017

Researchers found evidence of the degenerative brain disease in 110 out of 111 deceased NFL players

ALS-Related Muscle Cramp Drug Gains Fast Track Status

By July 25, 2017

Two Phase 2 trials of FLX-787 titled COMMAND and COMMIT are expected to start in the U.S. this quarter in ALS and Charcot-Marie-Tooth (CMT) patient populations, respectively.

Study Examines Link Between PPI Use and Alzheimer's Disease

June 29, 2017

"PPIs were not associated with greater risk of dementia or of Alzheimer's disease, in contrast to recent reports. Study limitations include reliance on self-reported PPI use and lack of dispensing data," the authors write.

Insomnia Drug May Help Patients with Disorders of Consciousness, Movement

By June 26, 2017

Researchers reviewed a total of 2,314 articles for zolpidem used to treat neurologic disorders across various databases.

Tafamidis Gets Fast Track Status for Rare Disease Linked to Progressive HF

By June 06, 2017

Vyndaqel is approved in Europe and a number of other countries to treat transthyretin familial amyloid polyneuropathy (TTR-FAP) but not in the U.S.

Low-Dose Aspirin Assessed for Cognitive Decline Protection

May 09, 2017

Over a median of 6 years of follow-up, chronic use of low-dose aspirin was not associated with onset of dementia or cognitive impairment.

FDA Approves First New ALS Drug in Over 20 Years

By May 08, 2017

The FDA's decision was supported by data from a clinical development program that lasted 13 years with multiple Phase 3 studies.