Miscellaneous Neurodegenerative Disorders

First-in-Class Therapy Approved for Polyneuropathy Caused by hATTR

By August 10, 2018

The mechanism of siRNAs consists of silencing a portion of RNA involved in causing the disease.

NIH Releases Large-Scale Dataset of CT Images

August 03, 2018

Unlike most lesion medical image datasets currently available, which can detect only 1 type of lesion, DeepLesion has much diversity and contains critical radiology findings from across the body, including lung nodules, liver tumors, and enlarged lymph nodes.

Alcohol Exposure Via Breastmilk May Affect Infant Development

August 02, 2018

The researchers found that in children who had been breastfed, there was a correlation for increased or riskier wave 1 maternal alcohol consumption with reductions in Matrix Reasoning scores at age 6 to 7.

Details of Montreal Cognitive Assessment Widely Publicized

July 23, 2018

The researchers identified 405 unique news articles, 190 of which discussed the MoCA in association with President Trump. More than half of these articles (53.7%) included part or all of the MoCA, with 44.2% presenting the questionnaire in its entirety.

Xeomin Approved to Treat Chronic Sialorrhea in Adults

By July 05, 2018

The approval was supported by data from a Phase 3, randomized, double-blind, placebo-controlled, multicenter (N=184) trial.

Walk Test IDs Risk of Cognitive Dysfunction Post Cardiac Surgery

June 15, 2018

"If we are able to identify patients who are at risk for POCD, we can provide early treatment and encourage them to better understand the dysfunction," Hayashi said in a statement.

Foods With Fat and Carbohydrate Are More Highly Valued

June 15, 2018

Individuals were better able to estimate the energy density of fat vs carbohydrate and fat + carbohydrate foods. This effect correlated with functional connectivity between the fusiform gyrus and ventromedial prefrontal cortex (visual and valuation areas).

Dexmedetomidine Cuts γ-Aminobutyric Acid Receptor Function

June 13, 2018

The researchers found that dexmedetomidine reduced the etomidate-induced sustained increase in α5 γ-aminobutyric acid type A receptor cell-surface expression (etomidate: 146.4 ± 51.6%; etomidate + dexmedetomidine: 118.4 ± 39.1% of control).

Long-Term Type 1 Diabetes Associated With Cognitive Decline

June 12, 2018

Researchers compared cognition in 82 individuals with 50 or more years of type 1 diabetes (Medalists), 31 age-matched individuals with type 2 diabetes, and 30 age-matched control subjects without diabetes.

Immunotherapy Promising for Slowing Progression of ALS

June 04, 2018

Increased Treg suppressive function was correlated with slowing of disease progression per the Appel ALS scale for each patient.

Neurologists Identify New Type of Vertigo

May 25, 2018

Over a median follow-up of 12 years from symptom onset, long-term prognosis was favorable, with a resolution or improvement of the symptoms in more than half of the patients, with none developing VM, MD, or cerebellar dysfunction.

Lenti-D Gets Breakthrough Tx Designation for Cerebral Adrenoleukodystrophy

By May 24, 2018

This investigational lentiviral-based gene therapy is currently being studied in the Phase 2/3 Starbeam Study, a 2-year study assessing the safety and efficacy of Lenti-D in boys ≤17 years old with CALD.

Better Diet Quality Associated With Larger Brain Volume

May 17, 2018

Specifically, larger brain volume was associated with high intake of vegetables, fruit, whole grains, nuts, dairy, and fish, and low intake of sugar-containing beverages.

Depressive Symptoms Tied to Memory, Aging of the Brain

May 10, 2018

With adjustment for sociodemographic, behavioral, and vascular risk factor variables, greater depressive symptoms were also associated with smaller cerebral parenchymal fraction (P=.02) and increased odds of subclinical brain infarcts (odds ratio, 1.55; P=.05).

Psychological Therapies May Help Older Adults With Chronic Pain

May 09, 2018

Researchers conducted a systematic review and meta-analysis evaluating the efficacy of CBT-based approaches for chronic pain among older adults.

Mild TBI Linked to Increased Dementia Risk in Veterans

May 08, 2018

The researchers observed small differences between veterans with and without TBI. Overall, 2.6 and 6.1% of those without and with TBI, respectively, developed dementia.

Anesthesia Before Age 3 Not Linked to Intelligence Deficits

May 01, 2018

In addition, the parents of multiply exposed children reported increased problems related to executive function, behavior, and reading.

Clinically Significant Anxiety Tied to Subsequent Dementia Risk

May 01, 2018

The researchers observed a positive correlation between clinically significant anxiety and future dementia in all studies. A meta-analysis was not conducted due to the heterogeneity between the studies.

Cerliponase Alfa Beneficial for Form of Batten's Disease

April 26, 2018

The researchers found that the median time until a 2-point decline in the motor-language score was not reached for treated patients and was 345 days for 42 historical controls.

Linear Link for Physical Activity, Amyotrophic Lateral Sclerosis

April 24, 2018

The researchers identified linear correlations for ALS and PA in leisure time, occupational activities, and all activities combined (odds ratios, 1.07, 1.06, and 1.06, respectively), with some heterogeneity identified between regions.

Controlling High Blood Pressure Could Prevent Dementia

April 24, 2018

The researchers found that 9% of participants developed dementia over a 24-year follow-up period. There was a significantly reduced risk of dementia among the 816 patients prescribed any antihypertensive medication compared to the 420 untreated hypertensive patients.

Grip Strength Indicative of Cognition in Major Depression

April 23, 2018

Handgrip strength was positively associated with improved visual memory, reaction time, prospective memory, and reasoning among individuals with bipolar disorder.

Annual Visits May Not Increase Cognitive Impairment Detection

April 23, 2018

The researchers found that there were no clinically relevant differences between the Medicare Annual Wellness Visits group and matched controls in the rates of incident Alzheimer's disease and related dementia (ADRD) diagnoses.

Small Link for Cannabis Use, Reduced Cognitive Functioning

April 19, 2018

Data were reviewed from 69 studies of 2,152 cannabis users (mean age, 20.6 years) and 6,575 comparison participants (mean age, 20.8 years) with minimal cannabis exposure.

Mild TBI May Increase Risk of Parkinson's Disease

April 19, 2018

The researchers found that 1,462 patients from the overall cohort of 325,870 patients were diagnosed with PD during follow-up.

FDA-Approved App Allows Clinicians to Objectively Measure Balance

By April 18, 2018

The application assesses 3 key balance metrics: (1) double stance, (2) right tandem stance, and (3) left tandem stance.

Negative Fateful Life Events Linked to Advanced Brain Aging

April 13, 2018

Participants were assessed for negative FLEs, health and well-being, general cognitive ability, socioeconomic status, depression, and ethnicity at 2 different time points.

Polypharmacy Linked to Poorer Cognitive, Physical Capability

April 09, 2018

In models adjusted for sex, education, and disease burden, both polypharmacy and excessive polypharmacy were correlated with poorer cognitive and physical capability, with stronger associations seen for excessive polypharmacy.

Traumatic Brain Injury Rare for Children With Isolated Vomiting

March 29, 2018

The characteristics of vomiting were assessed and correlated with clinical decision rule predictors and the presence of ci-TBI or TBI-CT.

Extremely preterm children more likely to develop motor impairment

March 22, 2018

This prospective cohort study showed that children born extremely premature (EP) or at an extremely low birth weight (ELBW) were more likely to develop cerebral palsy (CP) or non-CP motor impairment at 8 years' corrected age when compared to matched controls born at term.