Miscellaneous Neurodegenerative Disorders
The approval of Osmolex ER was based on bioavailability studies comparing Osmolex ER to immediate-release amantadine.
Banyan BTI (Brain Trauma Indicator) is an in vitro diagnostic blood test to aid in the evaluation of patients with suspected TBI.
The percentage of children who have ever had a significant head injury also increased as age increased, peaking at 11.7% among 15-to-17-year-old children.
The researchers found that HIV+ and HEU children had lower cognitive and motor scores than their HUU peers within the meta-analysis.
The correlation remained unchanged after further adjustment for sex, education, apolipoprotein E4, late-life cognitive activity, caloric intake, physical activity, and smoking (β = 0.08; P=0.03).
"Add-on cannabidiol is efficacious for the treatment of patients with drop seizures associated with Lennox-Gastaut syndrome and is generally well tolerated," the authors write.
The researchers found that the zonisamide 50mg group had significantly greater improvement in Unified Parkinson's Disease Rating Scale part 3 total score at week 12 versus placebo.
Significant changes in mean FDDNP were found at 18 months in the amygdala and hypothalamus regions of the brain, which control several memory and emotional functions.
Angelman syndrome affects approximately 1 in 12,000 to 20,000 in the U.S. and symptoms include delayed development, intellectual disability, and seizures.
Researchers from the University of Minnesota in Minneapolis reviewed data from 32 trials to examine the effectiveness of physical activity interventions in slowing cognitive decline and delaying the onset of cognitive impairment and dementia.
Treatments for cervical dystonia include oral medications, botulinum toxin injections, surgery, and complementary therapies.
Data were included for 262 patients with a history of WNV enrolled in a longitudinal cohort from 2002 to 2012; 117 patients underwent neurologic and neurocognitive evaluations.
The researchers found that the composite outcome of death or moderate to severe disability at 18 to 22 months occurred in 19 of 78 (24.4%) hypothermic infants and 22 of 79 (27.9%) noncooled infants.
The FDA based its approval of the extended indication for Soliris on comprehensive clinical data from the Phase 3, randomized, double-blind, placebo-controlled, multicenter REGAIN study (ECU-MG-301).
The researchers found that patients showed a significantly reduced number of conditioned eyeblink responses before alcohol administration versus controls.
The researchers found that, compared with placebo, the incidence of adverse reactions of ropinirole, rotigotine, entacapone, and sumanirole were higher in terms of nausea.
Researchers found an increased risk of dementia associated with both low serum magnesium levels (≤0.79 mmol/L) and high serum magnesium levels (≥0.90 mmol/L).
The researchers found that the mean change from baseline over time in the raw score for the spatial working memory strategy index of executive function was −0.21 ± 2.62 and −0.29 ± 2.81 in the evolocumab and placebo groups, respectively.
Forty patients were enrolled, including 29 with Guillain-Barré syndrome (GBS), 7 with encephalitis, 3 with transverse myelitis, and 1 with newly diagnosed chronic inflammatory demyelinating polyneuropathy. Diverse Spectrum of Neurologic Syndromes Seen With Zika