Miscellaneous Neurodegenerative Disorders

Does Adding Evolocumab to Statin Tx Impact Cognitive Function?

August 17, 2017

The researchers found that the mean change from baseline over time in the raw score for the spatial working memory strategy index of executive function was −0.21 ± 2.62 and −0.29 ± 2.81 in the evolocumab and placebo groups, respectively.

Study Reveals Diverse Neurologic Complications with Zika Virus

August 15, 2017

Forty patients were enrolled, including 29 with Guillain-Barré syndrome (GBS), 7 with encephalitis, 3 with transverse myelitis, and 1 with newly diagnosed chronic inflammatory demyelinating polyneuropathy. Diverse Spectrum of Neurologic Syndromes Seen With Zika

'Groundbreaking' Technology Heals Serious Injuries with a Single Touch

By August 09, 2017

"By using our novel nanochip technology, injured or compromised organs can be replaced. We have shown that skin is a fertile land where we can grow the elements of any organ that is declining," said Dr. Chandan Sen.

Radicava Now Available for the Treatment of ALS

By August 08, 2017

Radicava is supplied as a 30mg/100mL solution for intravenous infusion in single-dose polypropylene bags.

Memantine Started Quickly After TBI May Reduce Levels of Brain Damage Biomarker

By August 04, 2017

Before study initiation, NSE levels were similar for both groups. On Day 3 of the study, the NSE levels were 7.95 ± 2.86 ng/mL for the memantine group and 12.33 ± 7.09 ng/mL for the control group (P=0.05).

Fluoroquinolones May Up Risk of PTCS, a Rare But Serious Condition

By August 01, 2017

For this study, the researchers examined data from the LifeLink Database for cases with ICD-9-CM code for benign intracranial hypertension (BIH) as well as an MRI or CT scan and a lumbar puncture within 15 or 30 days of the BIH code.

Dementia Risk Up in Older Patients with Hearing Loss

July 31, 2017

The researchers found that in cross-sectional analyses, participants with self-reported or objective moderate and poor hearing were more likely to have a dementia diagnosis than those with normal hearing, after adjustment for potential confounders.

Demystifying Conversion Disorder: A Guide for Primary Care Clinicians

By July 26, 2017

Assessing conversion disorder and distinguishing it from other conditions can be challenging.

CTE Identified in Nearly All Donated Brains from NFL Players

July 26, 2017

Researchers found evidence of the degenerative brain disease in 110 out of 111 deceased NFL players

ALS-Related Muscle Cramp Drug Gains Fast Track Status

By July 25, 2017

Two Phase 2 trials of FLX-787 titled COMMAND and COMMIT are expected to start in the U.S. this quarter in ALS and Charcot-Marie-Tooth (CMT) patient populations, respectively.

Study Examines Link Between PPI Use and Alzheimer's Disease

June 29, 2017

"PPIs were not associated with greater risk of dementia or of Alzheimer's disease, in contrast to recent reports. Study limitations include reliance on self-reported PPI use and lack of dispensing data," the authors write.

Insomnia Drug May Help Patients with Disorders of Consciousness, Movement

By June 26, 2017

Researchers reviewed a total of 2,314 articles for zolpidem used to treat neurologic disorders across various databases.

Tafamidis Gets Fast Track Status for Rare Disease Linked to Progressive HF

By June 06, 2017

Vyndaqel is approved in Europe and a number of other countries to treat transthyretin familial amyloid polyneuropathy (TTR-FAP) but not in the U.S.

Low-Dose Aspirin Assessed for Cognitive Decline Protection

May 09, 2017

Over a median of 6 years of follow-up, chronic use of low-dose aspirin was not associated with onset of dementia or cognitive impairment.

FDA Approves First New ALS Drug in Over 20 Years

By May 08, 2017

The FDA's decision was supported by data from a clinical development program that lasted 13 years with multiple Phase 3 studies.

Serious Health Risks Linked to Artificially Sweetened Beverages

April 21, 2017

Analysis found that a higher recent and cumulative intake of artificially-sweetened soft drinks correlated with increased risk of ischemic stroke, all-cause dementia, and Alzheimer's disease dementia.

Does Iodide Supplementation Improve Neurodevelopment in Preterm Infants?

April 14, 2017

No significant difference in neurodevelopmental status at 2 years for infants with iodide vs. placebo

First Drug for Tardive Dyskinesia Gains Approval

By April 12, 2017

The FDA approval was based on efficacy data of Ingrezza in a 6-week clinical study (n=234) of patients who received Ingrezza vs. placebo.

Does Early Hydrocortisone Tx Impair Neurodevelopment in Preemies?

April 05, 2017

No statistically significant difference in neurodevelopment at 2 with hydrocortisone, placebo

Does Breastfeeding Impact Child Development?

March 28, 2017

After propensity matching, only statistically significant outcome was hyperactivity at age 3 years

Vitamin E, Selenium Assessed for Dementia Prevention

March 22, 2017

A total of 3,786 participants were randomized to vitamin E, selenium, vitamin E and selenium, or placebo

Case Report: Movement Disorder Linked to Foreign Body Ingestion

March 16, 2017

Case report describes 10-month-old girl admitted to PICU with sudden onset of movement disorder

CDC Investigating Unusual Amnestic Syndrome Cases

January 26, 2017

MRI of the head, toxicology screening, and neurologic consultation in adults aged ≥18 years with sudden-onset amnesia is recommended.

Drug, Therapy Combo Benefits TBI Patients with Cognitive Problems

By November 28, 2016

The findings, though preliminary, suggest that combined treatment with MAAT and methylphenidate can improve attention, episodic and working memory, and executive functioning following traumatic brain injury.

Hormone ID'd as Potential Cognitive Impairment Biomarker

October 11, 2016

Blood levels of ghrelin may be a predictor of executive function impairment in patients with type 2 diabetes mellitus (T2DM), according to a study published online September 30 in the Journal of Diabetes Investigation.

More Evidence that Zika Virus Can Cause Guillain-Barré Syndrome

October 06, 2016

Virus detected in body fluids of Colombians with Guillain-Barr syndrome

For Some Older Adults, Anticholinergics May Provide Cognitive Benefits

By September 29, 2016

Older adults with questionable cognitive impairment exposed to anticholinergics demonstrated higher global cognitive scores compared to those not exposed to anticholinergics, according to a study published in Drugs & Aging.

Reasons for Inappropriate Antibiotic Prescribing Explored in Elderly

September 29, 2016

Constitutional symptoms, including mentation, often lead to diagnostic testing and potentially inappropriate antibiotic prescribing in older patients suspected of having a urinary tract infection (UTI) or pneumonia, according to a study published online in the Journal of the American Geriatrics Society.

NDA Submitted for Spinal Muscular Atrophy Treatment

By September 27, 2016

Biogen and Ionis have completed the rolling submission of a New Drug Application (NDA) to the FDA for the approval of nusinersen, an invesigational treatment for spinal muscular atrophy (SMA), for which there is currently no approved treatment.

Reduction of Memory, Processing Speed Linked to Mercury Exposure

September 27, 2016

In young Faroese adults, aerobic fitness is associated with short-term memory and processing speed, and the correlation is attenuated by prenatal methylmercury exposure, according to a study published in Environmental Health Perspectives.