Miscellaneous Neurodegenerative Disorders

Osmolex ER OK'd for Parkinson's Disease, Drug-Induced Extrapyramidal Reactions

By February 20, 2018

The approval of Osmolex ER was based on bioavailability studies comparing Osmolex ER to immediate-release amantadine.

First Blood Test to Assess Concussion in Adults Gets FDA Approval

By February 15, 2018

Banyan BTI (Brain Trauma Indicator) is an in vitro diagnostic blood test to aid in the evaluation of patients with suspected TBI.

Cognitive Enhancement Therapy May Benefit Adults With Autism

February 13, 2018

Participants treated with CET were significantly more likely to gain competitive employment

CDC Reports Level of Significant Head Injuries Among U.S. Children

February 09, 2018

The percentage of children who have ever had a significant head injury also increased as age increased, peaking at 11.7% among 15-to-17-year-old children.

Neurodevelopmental Differences Examined in HIV+, HIV-Exposed Children

January 26, 2018

The researchers found that HIV+ and HEU children had lower cognitive and motor scores than their HUU peers within the meta-analysis.

Diet Adherence Substantially Lowers Cognitive Decline in Stroke Survivors

January 26, 2018

The correlation remained unchanged after further adjustment for sex, education, apolipoprotein E4, late-life cognitive activity, caloric intake, physical activity, and smoking (β = 0.08; P=0.03).

Cannabidiol Effective for Treatment-Resistant Lennox-Gastaut Syndrome

January 25, 2018

"Add-on cannabidiol is efficacious for the treatment of patients with drop seizures associated with Lennox-Gastaut syndrome and is generally well tolerated," the authors write.

Zonisamide Efficacy Assessed in Dementia With Lewy Bodies

January 25, 2018

The researchers found that the zonisamide 50mg group had significantly greater improvement in Unified Parkinson's Disease Rating Scale part 3 total score at week 12 versus placebo.

Significant Memory, Attention Benefits Associated With Curcumin Supplement

By January 23, 2018

Significant changes in mean FDDNP were found at 18 months in the amygdala and hypothalamus regions of the brain, which control several memory and emotional functions.

Traumatic Brian Injury Can Occur From Head-Injury Even Without Concussion

January 23, 2018

Concussion-like deficits after impact injury, lower shear diffuse stress after blast exposure in mice

DBS Efficacy, Safety Assessed in Patients With Tourette Syndrome

January 17, 2018

Improvement in mean total Yale Global Tic Severity Scale score at one year after DBS implantation

Treatment for Angelman Syndrome Gets Fast Track Status

By December 19, 2017

Angelman syndrome affects approximately 1 in 12,000 to 20,000 in the U.S. and symptoms include delayed development, intellectual disability, and seizures.

Interventions Reviewed for Late-Life Dementia Prevention

December 19, 2017

Researchers from the University of Minnesota in Minneapolis reviewed data from 32 trials to examine the effectiveness of physical activity interventions in slowing cognitive decline and delaying the onset of cognitive impairment and dementia.

Cervical Dystonia Drug Candidate Gets Orphan Drug Designation

By November 21, 2017

Treatments for cervical dystonia include oral medications, botulinum toxin injections, surgery, and complementary therapies.

Early cART, Viral Suppression May Minimize Brain Injury in HIV Patients

November 15, 2017

No significant neuropsychological decline during two-year period with combination antiretroviral therapy

Long-Term Effects of Valbenazine Examined in Adults With Tardive Dyskinesia

By November 14, 2017

Maintenance of treatment effect was demonstrated with both doses.

Previous West Nile Infection Linked to Neurologic Abnormalities

November 09, 2017

Data were included for 262 patients with a history of WNV enrolled in a longitudinal cohort from 2002 to 2012; 117 patients underwent neurologic and neurocognitive evaluations.

Nusinersen Beneficial in Infantile-Onset Spinal Muscular Atrophy

November 02, 2017

In additiona, a gene replacement therapy was found to be beneficial in spinal muscular atrophy type 1 (SMA1).

Hypothermia Tx Outcomes Examined for Newborns With Encephalopathy

October 26, 2017

The researchers found that the composite outcome of death or moderate to severe disability at 18 to 22 months occurred in 19 of 78 (24.4%) hypothermic infants and 22 of 79 (27.9%) noncooled infants.

Valbenazine Granted Orphan Drug Designation for Tourette Syndrome

By October 25, 2017

Valbenazine is already approved and marketed as Ingrezza in the US to treat adults with tardive dyskinesia

Soliris Approved to Treat Generalized Myasthenia Gravis

By October 24, 2017

The FDA based its approval of the extended indication for Soliris on comprehensive clinical data from the Phase 3, randomized, double-blind, placebo-controlled, multicenter REGAIN study (ECU-MG-301).

Better Risk Factor Modification Strategies Needed for Optimal Stroke Prevention

October 12, 2017

Increases in prevalence of hypertension, diabetes, dyslipidemia, smoking, and drug abuse in AIS

FDA Approves New Dosage Strength for Ingrezza

By October 05, 2017

The 80mg capsule is expected to be available in 30-count bottles within the next two weeks.

Movement Disorder Symptoms Found to Diminish with Alcohol Intake

September 22, 2017

The researchers found that patients showed a significantly reduced number of conditioned eyeblink responses before alcohol administration versus controls.

Adverse Effects Compared for Multiple Parkinson's Disease Drugs

September 21, 2017

The researchers found that, compared with placebo, the incidence of adverse reactions of ropinirole, rotigotine, entacapone, and sumanirole were higher in terms of nausea.

Mineral Level May Impact Dementia Risk

September 21, 2017

Researchers found an increased risk of dementia associated with both low serum magnesium levels (≤0.79 mmol/L) and high serum magnesium levels (≥0.90 mmol/L).

New Nymalize Ready-to-Use Dosing Option Available

By September 20, 2017

This new option is intended for patients who need a dosage lower than the standard 20mL (60mg) dose.

Link Between Cardiovascular Med Use and Cognitive Impairment Explored

September 01, 2017

No link for impaired cognition, antihypertensive, antithrombotic, lipid-modifying agent use

Does Adding Evolocumab to Statin Tx Impact Cognitive Function?

August 17, 2017

The researchers found that the mean change from baseline over time in the raw score for the spatial working memory strategy index of executive function was −0.21 ± 2.62 and −0.29 ± 2.81 in the evolocumab and placebo groups, respectively.

Study Reveals Diverse Neurologic Complications with Zika Virus

August 15, 2017

Forty patients were enrolled, including 29 with Guillain-Barré syndrome (GBS), 7 with encephalitis, 3 with transverse myelitis, and 1 with newly diagnosed chronic inflammatory demyelinating polyneuropathy. Diverse Spectrum of Neurologic Syndromes Seen With Zika