Miscellaneous Neurodegenerative Disorders

Rates of neurodevelopmental impairment unchanged in infants born ≤500g in Japan

November 16, 2018

Accurate data on long-term neurodevelopmental outcomes is critical for families and physicians to make informed decisions regarding resuscitation and care of these infants.

Fluoxetine Evaluated as Treatment for EV-D68 Acute Flaccid Myelitis

November 13, 2018

In a propensity-adjusted analysis, there was a 0.2 decrease and a 2.5 increase in SLSS from initial examination to latest follow-up for fluoxetine-treated and untreated patients, respectively (P=.015).

Symptom improvement after concussion in pediatrics expected within four weeks

November 12, 2018

In this large, pre-planned secondary analysis of a prospective multi-center cohort study, the majority of symptom improvement was consistently seen in the first week after concussion.

First-Of-Its-Kind Surgery Restores Boy's Ability to Walk Post-Acute Flaccid Myelitis

November 06, 2018

Nearly 400 people in the United States have been diagnosed since 2014, according to the US Centers for Disease Control and Prevention. So far this year, there have been 72 confirmed cases in 24 states.

Development Program for Glut1 Deficiency Syndrome Drug to Be Discontinued

By October 26, 2018

The decision was made after results from a Phase 3 trial (N=44) comparing UX007 to placebo did not show a statistically significant reduction in paroxysmal movement events in favor of the treatment (primary endpoint).

Tiglutik Now Available for the Treatment of Amyotrophic Lateral Sclerosis

By October 16, 2018

Tiglutik is supplied as a thickened riluzole liquid that is intended to ease administration for patients with dysphagia.

Optimizing Treatment for Patients With Chronic Sciatica: Gabapentin vs Pregabalin

By October 15, 2018

In this prospective, cohort study, patients (N=18) were randomized to receive gabapentin 400-800mg 3 times daily then pregabalin 150-300mg twice daily or vice versa; each treatment regimen was taken for 8 weeks with a 1-week washout period in between.

Tegsedi Approved for Polyneuropathy of Hereditary Transthyretin-Mediated Amyloidosis

By October 09, 2018

The approval was based on data from the Phase 3 NEURO-TTR study (N=173) which randomized patients with polyneuropathy caused by hATTR amyloidosis to Tegsedi or placebo.

Treatment Linked to Cognitive Scores in Breast Cancer Survivors

October 05, 2018

Researchers recruited 344 newly diagnosed non-metastatic breast cancer survivors matched with 347 cancer controls aged 60 years or older without dementia or neurological disease.

Global Cognition Up for Youth Meeting Movement Guidelines

October 02, 2018

The researchers found that the mean number of guidelines met was 1.1; 51, 37, and 18% of participants met the daily recommendations for sleep time (9 to 11 hours/night), screen time (2 hours or less), and physical activity (60 minutes or more), respectively.

Glial Cell Therapy Gets FDA's Orphan Drug Designation for Transverse Myelitis

By September 26, 2018

The Company has obtained Investigational New Drug (IND) clearance for Phase 1/2a trials of Q-Cells in both TM and amyotrophic lateral sclerosis (ALS).

Positive Results for Soliris in Neuromyelitis Optica Spectrum Disorder Trial

By September 24, 2018

In the PREVENT study, the safety and efficacy of Soliris was compared to placebo in patients with AQP4 auto antibody-positive NMOSD (N=143).

'Urgent' Need for Cannabinoid Trials in Ped Neurologic Disorders

September 21, 2018

Parents use unregulated cannabinoids to manage neurological disorders in children, including seizures, spasticity, and irritability in children with epilepsy, autism-spectrum disorder, and cerebral palsy.

Propofol May Decrease Delay in Neurocognitive Recovery

September 12, 2018

Cognitive function was assessed with a battery of neuropsychological tests before and 1 week after surgery (379 patients completed one-week neuropsychological testing).

Early language exposure predictive of language skills and IQ in school children

September 10, 2018

Language-based interactions between children 18 to 24 months of age and adults predicted intelligence quotient (IQ), verbal comprehension, and expressive and receptive language skills at 9 to 13 years old.

CDC: New Guideline for Pediatric Mild TBI Diagnosis, Management

September 10, 2018

Gradually increasing academic pursuits requires careful planning among the medical, school, and family units to enable prompt return and avoidance of prolonging school absence.

FDA Approves Tiglutik for the Treatment of Amyotrophic Lateral Sclerosis

By September 06, 2018

The FDA approval was supported by data from bioavailability studies comparing riluzole tablets and Tiglutik oral suspension.

Despite guidelines, use of CT for head trauma in children remains unchanged

September 05, 2018

The Pediatric Emergency Care Applied Research Network (PECARN) published clinical prediction rules in 2009 to identify children with head trauma for whom computed tomography (CT) neuroimaging can be avoided.

Patient Distressed by Overturn of California End of Life Option Act

September 05, 2018

In the Annals of Internal Medicine, the patient describes his perception that overturning the law shows a lack of compassion for terminally ill patients, asserting that in contrast to the "do no harm" of the Hippocratic oath, doctors are actually doing more harm by keeping terminally ill patients alive.

First-in-Class Therapy Approved for Polyneuropathy Caused by hATTR

By August 10, 2018

The mechanism of siRNAs consists of silencing a portion of RNA involved in causing the disease.

NIH Releases Large-Scale Dataset of CT Images

August 03, 2018

Unlike most lesion medical image datasets currently available, which can detect only 1 type of lesion, DeepLesion has much diversity and contains critical radiology findings from across the body, including lung nodules, liver tumors, and enlarged lymph nodes.

Alcohol Exposure Via Breastmilk May Affect Infant Development

August 02, 2018

The researchers found that in children who had been breastfed, there was a correlation for increased or riskier wave 1 maternal alcohol consumption with reductions in Matrix Reasoning scores at age 6 to 7.

Details of Montreal Cognitive Assessment Widely Publicized

July 23, 2018

The researchers identified 405 unique news articles, 190 of which discussed the MoCA in association with President Trump. More than half of these articles (53.7%) included part or all of the MoCA, with 44.2% presenting the questionnaire in its entirety.

Xeomin Approved to Treat Chronic Sialorrhea in Adults

By July 05, 2018

The approval was supported by data from a Phase 3, randomized, double-blind, placebo-controlled, multicenter (N=184) trial.

Walk Test IDs Risk of Cognitive Dysfunction Post Cardiac Surgery

June 15, 2018

"If we are able to identify patients who are at risk for POCD, we can provide early treatment and encourage them to better understand the dysfunction," Hayashi said in a statement.

Foods With Fat and Carbohydrate Are More Highly Valued

June 15, 2018

Individuals were better able to estimate the energy density of fat vs carbohydrate and fat + carbohydrate foods. This effect correlated with functional connectivity between the fusiform gyrus and ventromedial prefrontal cortex (visual and valuation areas).

Dexmedetomidine Cuts γ-Aminobutyric Acid Receptor Function

June 13, 2018

The researchers found that dexmedetomidine reduced the etomidate-induced sustained increase in α5 γ-aminobutyric acid type A receptor cell-surface expression (etomidate: 146.4 ± 51.6%; etomidate + dexmedetomidine: 118.4 ± 39.1% of control).

Long-Term Type 1 Diabetes Associated With Cognitive Decline

June 12, 2018

Researchers compared cognition in 82 individuals with 50 or more years of type 1 diabetes (Medalists), 31 age-matched individuals with type 2 diabetes, and 30 age-matched control subjects without diabetes.

Immunotherapy Promising for Slowing Progression of ALS

June 04, 2018

Increased Treg suppressive function was correlated with slowing of disease progression per the Appel ALS scale for each patient.

Neurologists Identify New Type of Vertigo

May 25, 2018

Over a median follow-up of 12 years from symptom onset, long-term prognosis was favorable, with a resolution or improvement of the symptoms in more than half of the patients, with none developing VM, MD, or cerebellar dysfunction.