Miscellaneous Neurodegenerative Disorders

Better Diet Quality Associated With Larger Brain Volume

May 17, 2018

Specifically, larger brain volume was associated with high intake of vegetables, fruit, whole grains, nuts, dairy, and fish, and low intake of sugar-containing beverages.

Depressive Symptoms Tied to Memory, Aging of the Brain

May 10, 2018

With adjustment for sociodemographic, behavioral, and vascular risk factor variables, greater depressive symptoms were also associated with smaller cerebral parenchymal fraction (P=.02) and increased odds of subclinical brain infarcts (odds ratio, 1.55; P=.05).

Psychological Therapies May Help Older Adults With Chronic Pain

May 09, 2018

Researchers conducted a systematic review and meta-analysis evaluating the efficacy of CBT-based approaches for chronic pain among older adults.

Mild TBI Linked to Increased Dementia Risk in Veterans

May 08, 2018

The researchers observed small differences between veterans with and without TBI. Overall, 2.6 and 6.1% of those without and with TBI, respectively, developed dementia.

Anesthesia Before Age 3 Not Linked to Intelligence Deficits

May 01, 2018

In addition, the parents of multiply exposed children reported increased problems related to executive function, behavior, and reading.

Clinically Significant Anxiety Tied to Subsequent Dementia Risk

May 01, 2018

The researchers observed a positive correlation between clinically significant anxiety and future dementia in all studies. A meta-analysis was not conducted due to the heterogeneity between the studies.

Cerliponase Alfa Beneficial for Form of Batten's Disease

April 26, 2018

The researchers found that the median time until a 2-point decline in the motor-language score was not reached for treated patients and was 345 days for 42 historical controls.

Linear Link for Physical Activity, Amyotrophic Lateral Sclerosis

April 24, 2018

The researchers identified linear correlations for ALS and PA in leisure time, occupational activities, and all activities combined (odds ratios, 1.07, 1.06, and 1.06, respectively), with some heterogeneity identified between regions.

Controlling High Blood Pressure Could Prevent Dementia

April 24, 2018

The researchers found that 9% of participants developed dementia over a 24-year follow-up period. There was a significantly reduced risk of dementia among the 816 patients prescribed any antihypertensive medication compared to the 420 untreated hypertensive patients.

Grip Strength Indicative of Cognition in Major Depression

April 23, 2018

Handgrip strength was positively associated with improved visual memory, reaction time, prospective memory, and reasoning among individuals with bipolar disorder.

Annual Visits May Not Increase Cognitive Impairment Detection

April 23, 2018

The researchers found that there were no clinically relevant differences between the Medicare Annual Wellness Visits group and matched controls in the rates of incident Alzheimer's disease and related dementia (ADRD) diagnoses.

Small Link for Cannabis Use, Reduced Cognitive Functioning

April 19, 2018

Data were reviewed from 69 studies of 2,152 cannabis users (mean age, 20.6 years) and 6,575 comparison participants (mean age, 20.8 years) with minimal cannabis exposure.

Mild TBI May Increase Risk of Parkinson's Disease

April 19, 2018

The researchers found that 1,462 patients from the overall cohort of 325,870 patients were diagnosed with PD during follow-up.

FDA-Approved App Allows Clinicians to Objectively Measure Balance

By April 18, 2018

The application assesses 3 key balance metrics: (1) double stance, (2) right tandem stance, and (3) left tandem stance.

Negative Fateful Life Events Linked to Advanced Brain Aging

April 13, 2018

Participants were assessed for negative FLEs, health and well-being, general cognitive ability, socioeconomic status, depression, and ethnicity at 2 different time points.

Polypharmacy Linked to Poorer Cognitive, Physical Capability

April 09, 2018

In models adjusted for sex, education, and disease burden, both polypharmacy and excessive polypharmacy were correlated with poorer cognitive and physical capability, with stronger associations seen for excessive polypharmacy.

Traumatic Brain Injury Rare for Children With Isolated Vomiting

March 29, 2018

The characteristics of vomiting were assessed and correlated with clinical decision rule predictors and the presence of ci-TBI or TBI-CT.

Extremely preterm children more likely to develop motor impairment

March 22, 2018

This prospective cohort study showed that children born extremely premature (EP) or at an extremely low birth weight (ELBW) were more likely to develop cerebral palsy (CP) or non-CP motor impairment at 8 years' corrected age when compared to matched controls born at term.

Impact of Menopausal Hormone Tx on Cognition Assessed 3-Years Post Treatment

March 22, 2018

The longitudinal decline in dorsolateral prefrontal cortex volumes was less in the tE2 group compared with the placebo group. In the menopausal hormone therapy groups, the rates of global cognitive change did not differ from that of the placebo group.

ADHD Incidence Increases Significantly Following Childhood TBI

March 20, 2018

The researchers found that 25.7% of the 187 children met the definition of SADHD. Compared with the OI group, severe TBI correlated with SADHD (hazard ratio [HR], 3.62; 95% confidence interval [CI], 1.59 to 8.26).

Risk of Altered Mental Status in Gabapentin-Treated Patients Explored

By March 15, 2018

The study included 110,184 adults (mean age: 76 years) newly started on gabapentin therapy in Ontario, Canada.

Treatment for Fragile X Syndrome Gets Fast Track Status

By March 15, 2018

A Phase 2 trial of OV101 in males with Fragile X syndrome aged 13 to 22 is planned for later in 2018. OV101 has previously been granted Orphan Drug status for Fragile X and Fast Track status for Angelman syndrome.

Peripheral Neuropathy Management: A Guide for Primary Care Clinicians

By March 14, 2018

Peripheral neuropathy is tied to significant morbidity and decrease in quality of life, therefore it is imperative to efficiently diagnosis.

Possible Association Between Diesel Exposure and Greater ALS Risk Identified

February 28, 2018

The researchers found that for men with any occupational exposure to DE, the odds ratio for ALS increased with increasing lag periods and was significant using a 10-year lag (adjusted odds ratio, 1.20). For men with >50% probability of DE exposure, the results were stronger.

Osmolex ER OK'd for Parkinson's Disease, Drug-Induced Extrapyramidal Reactions

By February 20, 2018

The approval of Osmolex ER was based on bioavailability studies comparing Osmolex ER to immediate-release amantadine.

First Blood Test to Assess Concussion in Adults Gets FDA Approval

By February 15, 2018

Banyan BTI (Brain Trauma Indicator) is an in vitro diagnostic blood test to aid in the evaluation of patients with suspected TBI.

Cognitive Enhancement Therapy May Benefit Adults With Autism

February 13, 2018

Participants treated with CET were significantly more likely to gain competitive employment

CDC Reports Level of Significant Head Injuries Among U.S. Children

February 09, 2018

The percentage of children who have ever had a significant head injury also increased as age increased, peaking at 11.7% among 15-to-17-year-old children.

Neurodevelopmental Differences Examined in HIV+, HIV-Exposed Children

January 26, 2018

The researchers found that HIV+ and HEU children had lower cognitive and motor scores than their HUU peers within the meta-analysis.

Diet Adherence Substantially Lowers Cognitive Decline in Stroke Survivors

January 26, 2018

The correlation remained unchanged after further adjustment for sex, education, apolipoprotein E4, late-life cognitive activity, caloric intake, physical activity, and smoking (β = 0.08; P=0.03).