Miscellaneous Neurodegenerative Disoders
The researchers conducted a prospective cohort study involving 23 patients who underwent treatment for facial synkinesis with botulinum toxin over multiple treatment cycles
A Phase 2 randomized, double-blind, placebo-controlled trial of AMX0035 titled CENTAUR (nct03127514) has begun with 132 ALS participants enrolled.
The researchers found that 2.9% of the 347 patients treated with anti-PD-1 monoclonal antibodies developed subacute onset of neurological complications.
Austedo, a vesicular monoamine transporter 2 (VMAT2) inhibitor, was initially approved to treat Huntington's chorea in April 2017.
Bedside exams often miss subtle signs Early detection of consciousness and brain function in the intensive care unit could allow families to make more informed decisions about the care of loved ones," co-lead author Brian Edlow.
After multivariable adjustment - which included duration of chronic medical conditions - a modest statistically significant association was only seen for psychomotor speed and attention.
"Immunomodulatory therapy should be considered early, because NSAIDs or a short course of oral corticosteroids may be sufficient for symptom remission in recent-onset cases, whereas those with long-standing symptoms often require more intensive and prolonged immunotherapeutic interventions," the authors write.
Study authors concluded that patients taking tetrabenazine three times daily can safely be converted to deutetrabenazine twice daily, while maintaining chorea control.
The researchers found that in fully adjusted models, participants with mid and high MedDiet scores were less likely to have poor cognitive performance than those with low scores.
These cognitive costs were highest for those with the highest dependence on smartphones. This smartphone-induced brain drain can have practical implications for decision-making and consumer welfare.
Overall, moderate drinkers were more than 3 times as likely as abstainers to show abnormal levels of atrophy in the right hippocampus. That included people who averaged 14 to 21 units of alcohol each week.
The analysis found that the simulated maternal serum concentration associated with the lowest probability of infant cerebral palsy was 4.1mg/dL, while the simulated total administered magnesium dose associated with the lowest probability of delivering an infant with cerebral palsy was 64g.
The authors examined long-term opioid therapy, defined by 1 or multiple consecutive opioid prescriptions resulting in 90 days or more of opioid use.
There was also an approximate 58% relative risk reduction in death or certain disease progression events in the 48-week Radicava group versus those given placebo initially.
Ionis announced positive results from the Phase 3 study of inotersen (IONIS-TTRRx) for the treatment of familial amyloid polyneuropathy (FAP), now referred to as hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN).
The FDA has granted Fast Track designation to trigriluzole (BHV-4157; Biohaven) for the potential treatment of Spinocerebellar Ataxia (SCA), a rare and debilitating neurodegenerative disorder.
Five lamb fetuses of 105 to 108 days of gestation were run for 25-28 days, and three fetuses of 115 to 120 days of gestation were run for 20-28 days.
Researchers found that nursing homes enrolled in the OASIS program had a 7.6% drop in antipsychotic prescriptions, compared with a 3.9% decline at the other nursing homes.
The analysis showed that over a median of 6 years, chronic use of low-dose aspirin was not associated with onset of dementia or cognitive impairment.
The researchers found that higher baseline HOMA-IR and fasting insulin levels were independent predictors of poorer verbal fluency performance (P=0.0002 for both) and of a greater decline in verbal fluency over follow-up (P=0.004 for both).
Researchers found that changes in neuroendocrine hormones were seemingly involved in symptoms of chronic tension-type headaches.
Mr. Musk is calling the brain implant 'neural lace', and in addition to possibly giving humans artificial intelligence, it may also be used to improve memory function.
To examine any potential cognitive improvement, researchers conducted a crossover study of modafinil, methylphenidate, caffeine and placebo.
Donepezil should not be prescribed to patients with mild cognitive impairment without first giving them a genetic test, according to research published recently in the Journal of Alzheimer's Disease.
The anti-inflammatory biologic drug anakinra (Kineret) does not reduce fatigue severity in women with chronic fatigue syndrome, according to a study published online March 7 in the Annals of Internal Medicine.