Miscellaneous Musculoskeletal Disorders

Adding Chiropractic to Usual Care Beneficial for Low Back Pain

May 18, 2018

"This trial provides additional support for the inclusion of chiropractic care as a component of multidisciplinary health care for low back pain, as currently recommended in existing guidelines," the authors write.

Vertebroplasty Does Not Up Pain Relief in Osteoporotic Fracture

May 10, 2018

"Percutaneous vertebroplasty did not result in statistically significantly greater pain relief than a sham procedure during 12 months' follow-up among patients with acute osteoporotic vertebral compression fractures," the authors write.

Pharmacists Can Play Role in Identifying Frailty

May 07, 2018

Community pharmacists can identify certain risk factors for frailty, including gender, low socioeconomic status, chronic illnesses, neuroendocrine dysfunctions, and certain medications and medication regimens.

Facioscapulohumeral Muscular Dystrophy Treatment Gets Fast Track Status

By May 02, 2018

ACE-083 is currently being studied in a Phase 2 trial for FSHD and another for Charcot-Marie-Tooth (CMT) disease.

Neuromodulation Therapy Gives Relief From Hand Tremor

April 20, 2018

"Our research suggests that this non-invasive therapy may offer meaningful relief from the symptoms of hand tremor for people with essential tremor," Pahwa said in a statement.

Less Pain Post TKA With Addition of Peripheral Nerve Blocks

April 19, 2018

The researchers found that intervention patients reported lower numeric rating scale pain scores on ambulation than the control group on postoperative day (POD) one (1.7 versus 5.0; P <.001).

New Drug May Help Infants With Spinal Muscular Atrophy

April 19, 2018

The researchers identified a dose-dependent increase in SMN protein levels in blood; compared with baseline, there was up to a 6.5-fold increase after 4 weeks of treatment at the highest dose of RG7916 (range, 2.0 to 6.5).

FDA-Approved App Allows Clinicians to Objectively Measure Balance

By April 18, 2018

The application assesses 3 key balance metrics: (1) double stance, (2) right tandem stance, and (3) left tandem stance.

Young Adults With T1DM Show Muscle Metabolic Deficiencies

April 18, 2018

Participants with type 1 diabetes had an increase in the size and number of autophagic remnants in muscles; however, levels of the autophagic regulatory protein, phosphorylated AMP-activated protein kinase, and its downstream targets were similar between groups.

USPSTF: Exercise Interventions Prevent Falls in Seniors

April 18, 2018

The harms of exercise and multifactorial interventions was found to be no greater than small. Based on these findings, the USPSFT recommends exercise interventions to prevent falls among those at increased fall risk (B recommendation).

Neuroscience Education, Motor Control Training Ease Spinal Pain

April 17, 2018

The researchers found that reduced pain, higher pressure pain thresholds at primary test site at 3 months, and reduced central sensitization inventory scores at 6 and 12 months were experienced by participants in the experimental group.

Elamipretide Granted Orphan Drug Status for Barth Syndrome

By April 09, 2018

The TAZPOWER study is a randomized, double-blind, placebo-controlled Phase 2/3 crossover study evaluating the safety and efficacy of elamipretide (daily subcutaneous injections) in 12 male patients (aged ≥12 years) with genetically-confirmed Barth syndrome.

Polypharmacy Linked to Poorer Cognitive, Physical Capability

April 09, 2018

In models adjusted for sex, education, and disease burden, both polypharmacy and excessive polypharmacy were correlated with poorer cognitive and physical capability, with stronger associations seen for excessive polypharmacy.

First-in-Class Inhibitor Designated Orphan Drug for Spinal Muscular Atrophy

By March 29, 2018

By inhibiting the activation of myostatin, SRK-015 may promote a clinically meaningful increase in muscle mass and strength.

MVPA Mortality Risk Reduction Not Tied to Exercise in Bouts

March 26, 2018

Physical activity data were processed to generate minutes/day of total and bouted MVPA, with bouted MVPA defined as MVPA accumulated in bouts of a minimum duration of five or 10 minutes.

Human neural stem cell grafts in rhesus monkeys improve motor function after injury

March 20, 2018

Following cervical spinal cord injury, rhesus monkeys were grafted with human neural progenitor cells.

Tamoxifen, Raloxifene Linked to Improvements in Muscular Dystrophy

March 20, 2018

Improvements include increase in grip force production, extended running time and distance

Menopausal Hormone Therapy May Aid in Reducing Spine Injury

February 23, 2018

The researchers found that, compared with never-users of HT, continuous users had a mean Cobb angle that was 4.0 degrees less, in minimally-adjusted models (P=0.01); in fully-adjusted models, the correlation was attenuated to 2.8 degrees (P=0.06).

Nusinersen improves motor function in children with later-onset spinal muscular atrophy

February 15, 2018

Intrathecal injections of nusinersen in pediatric later-onset spinal muscular atrophy (SMA) patients were associated with increased clinical motor function scores compared to sham treated patients.

Nusinersen Beneficial in Children With Later-Onset Spinal Muscular Atrophy

February 15, 2018

Significant improvement in motor function compared with sham procedure among children with SMA

Mogamulizumab is safe and possibly effective in HTLV-1-associated myelopathy

February 12, 2018

In this combined phase 1-2a study, mogamulizumab used for treatment of human T-lymphotropic virus type 1 (HTLV-1) associated myelopathy was safe and associated with improvement in biomarkers of disease, as well as improvements in spasticity and motor disability.

Relationship Between Opioid Use and Patient Satisfaction Explored

January 24, 2018

The researchers found that 13.1% of patients with musculoskeletal conditions were opioid users, defined as receiving at least 1 prescription in two 6-month time periods.

Shorter overall survival among patients with monoclonal gammopathy of undetermined significance

January 23, 2018

Patients diagnosed with monoclonal gammopathy of undetermined significance (MGUS) and followed for multiple decades showed shorter overall survival rates compared to matched controls.

Onabotulinum Toxin-A Injections May Benefit Patients With Sleep Bruxism

January 18, 2018

The researchers found that clinical global impression (P<0.05) and visual analog scale of change (P<0.05) in bruxism and in pain favored the BoNT-A group.

A structured exercise program provides mobility benefits to all older patients, regardless of frailty status

January 16, 2018

The effect of physical activity at reducing the likelihood of major mobility disability (MMD) was not impacted by the baseline frailty status of patients in the study.

USPSTF Updates Recommendation Statement on Scoliosis Screening

January 10, 2018

"Our review of the current evidence has pointed to more questions than answers about the benefits and harms of screening children and teenagers with no symptoms of scoliosis," said USPSTF member Alex R. Kemper, MD, MPH.

Certain Drug Classes Tied to Less Frequent Driving Impairment Warnings

By December 01, 2017

More than two-thirds (85%) of those on sedatives and narcotics reported being counseled by a provider on the possibility of impaired driving.

Hemophilic Arthropathy Treatment Gets Orphan Drug Designation

By November 27, 2017

TRM-201 (rofecoxib) is a highly potent COX-2 selective non-steroidal anti-inflammatory drug (NSAID) with a well-established efficacy profile.

Cervical Dystonia Drug Candidate Gets Orphan Drug Designation

By November 21, 2017

Treatments for cervical dystonia include oral medications, botulinum toxin injections, surgery, and complementary therapies.

Exercise Intensity and Mortality Risk: What's the Link?

November 08, 2017

A significant inverse correlation was seen in age- and wear time-adjusted analysis for LPA, but this correlation was no longer apparent after adjustment for potential confounders and MVPA.