Miscellaneous Musculoskeletal Disorders

Onabotulinum Toxin-A Injections May Benefit Patients With Sleep Bruxism

January 18, 2018

The researchers found that clinical global impression (P<0.05) and visual analog scale of change (P<0.05) in bruxism and in pain favored the BoNT-A group.

A structured exercise program provides mobility benefits to all older patients, regardless of frailty status

January 16, 2018

The effect of physical activity at reducing the likelihood of major mobility disability (MMD) was not impacted by the baseline frailty status of patients in the study.

USPSTF Updates Recommendation Statement on Scoliosis Screening

January 10, 2018

"Our review of the current evidence has pointed to more questions than answers about the benefits and harms of screening children and teenagers with no symptoms of scoliosis," said USPSTF member Alex R. Kemper, MD, MPH.

Certain Drug Classes Tied to Less Frequent Driving Impairment Warnings

By December 01, 2017

More than two-thirds (85%) of those on sedatives and narcotics reported being counseled by a provider on the possibility of impaired driving.

Hemophilic Arthropathy Treatment Gets Orphan Drug Designation

By November 27, 2017

TRM-201 (rofecoxib) is a highly potent COX-2 selective non-steroidal anti-inflammatory drug (NSAID) with a well-established efficacy profile.

Cervical Dystonia Drug Candidate Gets Orphan Drug Designation

By November 21, 2017

Treatments for cervical dystonia include oral medications, botulinum toxin injections, surgery, and complementary therapies.

Exercise Intensity and Mortality Risk: What's the Link?

November 08, 2017

A significant inverse correlation was seen in age- and wear time-adjusted analysis for LPA, but this correlation was no longer apparent after adjustment for potential confounders and MVPA.

Does Drinking Water Before Vaccination Prevent Postvaccination Presyncope?

October 24, 2017

In multivariable analysis, presyncope was correlated with younger age, history of passing out or nearly passing out after an injection or blood draw, anxiety before vaccination, receiving more than one injected vaccine, and greater post-vaccination pain.

USPSTF Issues New Fall Prevention Recommendations

September 27, 2017

Multifactorial interventions to prevent falls should be offered selectively by clinicians; the overall net benefit of routinely offering multifactorial interventions is small.

Limiting Sedentary Time 'Necessary' to Avoid Mobility Loss

August 31, 2017

At the study's end, 29% of participants were either unable to walk or had difficulty doing so.

Octagam 10% Gains Orphan Drug Status for Rare Muscle, Skin Disorder

July 17, 2017

Octagam 10% is currently approved to treat chronic immune thrombocytopenic purpura (ITP) in adult patients. It is supplied as 2g, 5g, 10g, or 20g single-use bottles.

Research Paper Reviews JFK's Chronic Health Issues

By July 14, 2017

A new review published in the Journal of Neurosurgery: Spine details the health issues that troubled JFK the most, specifically his back. His low-back pain was instigated by a football injury sustained while he was at Harvard in 1937. An orthopedic spine specialist diagnosed him in 1940 with a "very unstable lumbosacral joint".

Is Radiofrequency Denervation Effective for Chronic Low Back Pain?

By July 05, 2017

Results showed a statistically significantly, but not a clinically important, improvement in two of the trials which evaluated radiofrequency denervation for the sacroiliac joints (−0.71 (95% CI, −1.35 to −0.06) and a combination of the facet joints, sacroiliac joints or intervertebral disks (−0.99 (95% CI, −1.73 to −0.25) at 3 months.

From Treatment to Training: 5 Uses of Virtual Reality in Healthcare

June 27, 2017

Virtual reality is much more than just a new form of entertainment, it is increasingly being used in a wide range of medical applications.

Back Pain, Depression and Opioids: Research Uncovers Rx Pattern

June 23, 2017

The analysis of nationwide data from 2004 to 2009 found that patients with back pain who screened positive for depression were more than twice as likely to be prescribed an opioid.

Higher Alcohol Intake May Up Muscle Loss, Function for Some Women

By June 07, 2017

The data showed sarcopenia was 4 times more prevalent for the high-risk alcohol drinking group vs. the low-risk alcohol drinking group (odds ratio 4.29, 95% CI: 1.87, 9.82).

Case: Inhaled Corticosteroid-Induced Myopathy in HIV Patient

By May 26, 2017

Initially, the team attributed the muscle weakness to either HIV or drug-mediated myopathy but a muscle biopsy later revealed atrophy of type II fibers without necrosis or inflammation.

Fast Track Status Granted to Tideglusib for Myotonic Dystrophy

By May 17, 2017

In preclinical studies, AMO-02 has shown efficacy in transgenic models and reversal of muscle cell differentiation deficits in ex vivo tissue samples.

Are Statin Users at Greater Risk for Back Disorders?

By May 03, 2017

Previous research has demonstrated a link between statin use and use-related injury and arthropathies.

Review: Evaluating Patients for Primary Exercise Addiction

April 27, 2017

Practitioners can evaluate a patient for exercise addiction by exploring a patient's motivation for exercise, determining whether they cut back when injured, exploring the patient's emotional connection to exercise, and assessing whether exercise interferes with other aspects of life.

Spinraza Beneficial in Later-Onset Spinal Muscular Atrophy

By April 24, 2017

The CHERISH study was a multicenter, randomized, double-blind, sham-procedure controlled study to evaluate the safety and efficacy of Spinraza in children with later-onset SMA (n=126) aged 2-12 years.

Movement Disorders Examined in Current, Past Stimulant Drug Users

By April 21, 2017

The researchers concluded that stimulant drug use may result in acute stimulant-induced tremor as well as long-term proprioceptive deficits in terms of arm-droop.

First Drug for Tardive Dyskinesia Gains Approval

By April 12, 2017

The FDA approval was based on efficacy data of Ingrezza in a 6-week clinical study (n=234) of patients who received Ingrezza vs. placebo.

Music Therapy Relieves Post-Op Pain in Spinal Surgery Patients

April 10, 2017

Researchers provided 30 patients who'd had spinal fusion surgery with a 30-minute music therapy session within 72 hours of their operation, while another group received only standard care after their procedure.

Experimental Device Helps Paralyzed Man Feed Himself

March 29, 2017

Researchers utilized functional electric stimulation intracortical brain-computer interface system

Diabetic Peripheral Neuropathy Treatments Explored

March 27, 2017

The researchers identified an additional 24 published studies and 25 unpublished studies, since the last completed systematic review of 57 eligible studies.

Glucocorticoid Intradiscal Injection Evaluated for Low Back Pain Relief

March 21, 2017

The researchers found that percentage of responders (LBP intensity <40 on an 11-point numerical rating scale) was higher in the GC IDI group than the control group at one month after the intervention.

Is Direct Home Discharge Better for Arthroplasty Recovery?

March 17, 2017

One study found that patients who are discharged directly home following a total knee arthroplasty face a lower risk for complications and hospital readmission than those who first go to an inpatient rehab facility.

Musculoskeletal Symptoms May Precede PsA Diagnosis

March 13, 2017

Prediction of subsequent PsA was associated with baseline presence of arthralgia in women (hazard ratio [HR], 2.59), heel pain (HR, 4.18), high fatigue score (HR, 2.36), and high stiffness score (HR, 2.03).