Miscellaneous Gastrohepatic Disorders

DAA Treatment and Hepatic Fibrosis Improvement in HCV: What's the Link?

By November 13, 2018

The study aimed to determine whether direct-acting antiviral therapy reduced fibrosis and assessed whether any predictors of treatment failure existed at 1-year follow-up.

Rituximab Linked to HBV Reactivation in Patients With Prior Functional Cure

By October 09, 2018

The study authors searched MEDLINE from inception through July 2018 to obtain relevant cohort studies and randomized trials assessing HBVr incidence secondary to pharmaceutical agents.

Antibiotic Tx Appears to Be a Reasonable Option for Uncomplicated Acute Appendicitis

By September 26, 2018

The study included 530 patients, aged 18 to 60 years, with computed tomography-confirmed uncomplicated acute appendicitis.

Out-of-Pocket Costs Similar for Infliximab, Infliximab-Dyyb

September 05, 2018

"Although biosimilar gap discounts begin in 2019, infliximab-dyyb may still not significantly reduce Part D beneficiaries' out-of-pocket costs given its high price and coinsurance cost-sharing similar to infliximab," the authors write.

FDA Warns of Dangers of Liquid Nitrogen in Food, Drinks

September 04, 2018

Liquid nitrogen isn't toxic, but its extremely low temperature can cause severe damage to skin and internal organs if mishandled or consumed, the FDA said in a news release.

Treatments for Primary Prevention of Esophageal Variceal Bleeding Compared

By August 22, 2018

Treatments (NSBB, isosorbide mononitrate, carvedilol, variceal band ligation) were compared as monotherapy or as combination therapy with each other or versus placebo.

Lenvima OK'd as First-Line Treatment for Unresectable Hepatocellular Carcinoma

By August 16, 2018

The approval was supported by findings from the multicenter, randomized, open-label, noninferiority trial, REFLECT (N=945), which included patients with previously untreated, metastatic or unresectable HCC.

Opdivo + Yervoy Approved to Treat MSI-H/dMMR Metastatic Colorectal Cancer

By July 12, 2018

The approval was based on data from the ongoing Phase 2 CheckMate-142 study which enrolled patients with MSI-H/dMMR metastatic CRC who had received ≥1 prior line of therapy for metastatic disease (N=119).

Keytruda sBLA Granted Priority Review for Advanced Hepatocellular Carcinoma

By July 11, 2018

The sBLA is based on results from the Phase 2 KEYNOTE-224 trial, which enrolled 104 individuals with advanced hepatocellular carcinoma previously treated with sorafenib who were either intolerant to or showed progression of disease after treatment.

Hydralazine-Induced Hepatotoxicity Described in Case Report

By July 09, 2018

Symptoms in patients with short latency include fever, rash, and eosinophilia.

AMA Urges Caution With Use of Wire-Bristle BBQ Grill Brushes

July 04, 2018

Precautions should be taken, including wiping down grill after use and inspecting it for wire bristles

Pembrolizumab Not Better Than Paclitaxel for Advanced Gastric Cancer

July 03, 2018

Survival no better with second-line pembrolizumab than paclitaxel for gastric, gastro-esophageal cancer

Most Bleeding Events in Non-CVD Patients Are GI-Related

June 28, 2018

The risk of a nonfatal GI bleeding event was 2.19 per 1,000 person-years in the baseline cohort, 1.77 in the non-high-risk cohort, and 1.61 in the nonmedication cohort.

Cannabinoid-Based Tx Gets Orphan Drug Designation for Autoimmune Hepatitis

By June 27, 2018

Cannabidiol is a non-psychoactive component of marijuana that does not cause intoxication or euphoria that comes from tetrahydrocannabinol.

Honey + Sucralfate May Reduce Injury After Accidental Button Battery Ingestion

By June 11, 2018

Noting that infants and children who ingest button batteries can experience esophageal damage leading to significant morbidity and death in as little as 2 hours, researchers from the Children's Hospital of Philadelphia and Nationwide Children's Hospital aimed to identify effective options for mitigating these effects by testing common weakly acidic household beverages, viscous liquids, and sucralfate (Carafate).

HCV Guidelines Updated to Include Recommendations for Key Populations

By May 25, 2018

The guidelines were developed by the American Association for the Study of Liver Diseases and the Infectious Diseases Society of America.

Opioids Often Overprescribed After Hiatal Hernia Surgery

May 03, 2018

Patients use fewer opioids than are prescribed after open, laparoscopic hiatal hernia repair

Factors ID'd to Predict Fatty Liver in Obese Teens

April 24, 2018

"The combination of ethnicity/race with markers of insulin resistance and genetic factors might help identify obese youth at risk for developing fatty liver," the authors write.

Optimizing organ donations from overdose deaths may help address national organ shortage

April 19, 2018

U.S. transplants using organs from overdose-death donors (ODDs) has increased 24-fold from 2000 to 2016, and transplant outcomes from organs donated by ODDs have been noninferior to those donated by trauma-death donors (TDDs) and medical-death donors (MDDs).

Oral Nitroglycerin Solution: An Effective Option for Esophageal Food Impaction?

By April 09, 2018

While glucagon is often used for the treatment of esophageal food impaction, its effectivess, based on several studies, has been inconsistent.

Obesity Can Negatively Affect Liver in Children As Young As 8

April 06, 2018

Each additional 10cm greater waist circumference at early childhood was associated with 1.99 higher odds of elevated ALT at mid-childhood, in multivariable-adjusted models.

Livantra Granted Orphan Drug Status for Acute-on-Chronic Liver Failure

By March 30, 2018

Livantra may help rate of survival without transplantation or help improve survival until patients can receive a new liver.

Liver Disease, Insulin Resistance Associated With High Red Meat Consumption

March 20, 2018

The researchers found that after adjusting for body mass index, physical activity, smoking, alcohol, energy, saturated fat and cholesterol intake, the odds of NAFLD and IR were increased in association with high consumption of total meat.

Does Gut Bacteria Translocate to the Brain During Sepsis?

March 15, 2018

Among humans who died of sepsis, bacterial taxa detected in their brains were distinct from those who died of noninfectious causes and were correlated with S100A8/A9 expression.

Hyperandrogenism May Impact Gut in Polycystic Ovary Syndrome

January 24, 2018

There was a change in alpha diversity of women with PCOM that was intermediate between the other two groups. Regression analyses revealed a negative correlation of hyperandrogenism, total testosterone, and hirsutism with alpha diversity.

Triple Therapy Linked to Mortality Rate in CAD With GI Bleeding

December 06, 2017

Increased mortality at 90 days in patients with lower gastrointestinal bleeding, coronary artery disease

Frequency of Celiac Disease Testing Examined in Patients with IDA

By November 30, 2017

The subgroup that was most frequently tested was young Caucasian men, with 61% of respondents stating that they would implement serologic testing in this group.

Long-Term Aspirin Use Linked to Reduced Incidence of GI Cancers

By October 31, 2017

Researchers compared patients who were prescribed aspirin over a long period (for at least six months, average duration of aspirin prescribed was 7.7 years) with non-aspirin users and assessed the incidences of a number of cancers.

Intrahepatic Cholestasis Following Regular Consumption of Herbal Tea

By October 17, 2017

The case involved a 30-year-old female with a history of anxiety and migraine who presented with complaints of malaise, right upper quadrant pain, worsening jaundice, dark colored urine, and itching; these symptoms had been going on for a few weeks.