Miscellaneous Dermatological Conditions

Iclaprim Gets Priority Review for Acute Bacterial Skin/Skin Structure Infections

By August 15, 2018

Clinical data has indicated that the drug exhibits a low propensity for resistance development as well as a favorable tolerability profile.

Gene Therapy Gets Orphan Drug Designation for Severe Genetic Skin Disease

By August 13, 2018

Patients with TGM-1 deficiency may have chronic pronounced scaling of the skin with increased transepidermal water loss, as the TGM-1 enzyme is essential for facilitating the formation of the epidermal barrier, which prevents dehydration.

Omadacycline Gets FDA Committee Nod for Skin Infections, Pneumonia

By August 09, 2018

The Committee's recommendation was based on data from the omadacycline global development program that included nearly 2000 adults in three Phase 3 studies.

Skin Appears to Be Key Pathway for Absorption of BBQ Fumes

August 06, 2018

"In the case of BBQ fumes, dermal absorption was a more important pathway for intake of low-molecular-weight PAHs than inhalation," the authors write.

Teen Boy Suffers Serious Burns After 'Hot Water Challenge'

July 31, 2018

Clark spent a week in the hospital. His doctors are hopeful that pigment will return in Clark's face within a few months.

Atopic Dermatitis Places Heavy Burden on Patients

July 20, 2018

Adults with AD reported higher proportions of having only fair/poor overall health, being somewhat/very dissatisfied with life, having lower weighted mean Short-Form 12 (SF-12) mental and physical health subscores, and having higher Dermatology Life Quality Index scores, compared to adults without AD.

Fish Pedicure Causes Woman to Lose Toenails

July 16, 2018

Dermatologists should be aware of potential skin, nail problems tied to fish pedicures

Topical JAK Inhibitor Granted Fast Track Designation for Alopecia Areata

By July 09, 2018

ATI-502 is a topical Janus Kinase (JAK) 1/3 inhibitor.

Novel Treatment for Primary Axillary Hyperhidrosis Gets FDA Approval

By June 29, 2018

The approval was supported by Phase 3 data from the ATMOS-1 and ATMOS-2 trials which evaluated the absolute change from baseline in sweat production after treatment with Qbrexza, and the proportion of patients who achieved ≥4-point improvement from baseline in their sweating severity (as measured by the Axillary Sweating Daily Diary [ASDD]).

Treatment for Necrobiosis Lipoidica Gets Orphan Drug Designation

By June 22, 2018

In a press release Dr. David Young, CEO of Processa said "We plan to begin our clinical studies in 2018 and to accelerate the development of PCS499 in order to provide clinical benefit to [necrobiosis lipoidica] patients as soon as possible."

Treatment of Hidradenitis Suppurativa with SAPHO Syndrome: A Case Review

By June 21, 2018

The male patient presented in 2009 with a "3-year history of multiple interconnecting comedones in the axilla and inguinal regions, as well as scarring from previous lesions."

Topical Rapamycin Effective for TSC-Related Facial Angiofibromas

June 11, 2018

The researchers observed clinically meaningful and statistically significant improvement in facial angiofibromas for 1 and 0.1% rapamycin versus vehicle only, and for 1 vs 0.1% rapamycin; most of the improvement was seen in the first month.

Rituxan Approved for Moderate to Severe Pemphigus Vulgaris

By June 08, 2018

The approval was based on data from the Ritux 3 trial (N=90) which compared rituximab + short-term oral prednisone (Ritux 3 regimen) to oral prednisone alone as a first-line treatment for patients with newly diagnosed moderate to severe PV.

Physician Sued for Negligence After Relying on Patient's Self-Diagnosis

By June 04, 2018

This month we look at the issue of whether a physician can be liable for relying on information provided by the patient.

Topically-Applied Gene Tx Fast-Tracked for Dystrophic Epidermolysis Bullosa

By May 25, 2018

KB103 is a replication-defective, non-integrating viral vector that utilizes the Company's STAR-D platform to deliver functional human COL7A1 genes directly to the patients' dividing and non-dividing skin cells.

Research Lacking on Platelet-Rich Tx for Facial Aesthetics, Alopecia

May 25, 2018

The researchers identified 7 studies that used platelet-rich plasma alone for facial rejuvenation, 7 in combination with fat grafting, 2 for treatment of acne scarring, and 6 for treatment of androgenic alopecia.

Positive Results for Dupilumab in Teen Atopic Dermatitis Trial

By May 16, 2018

The primary endpoint was the proportion of patients with an IGA score of 0 (clear) or 1 (almost clear) at Week 16.

Topical Treatment for Epidermolysis Bullosa Gets FDA's Rare Pediatric Designation

By May 16, 2018

A previous Phase 2 trial of 17 patients with EBS showed that 60% of those treated with diacerein cream experienced at least a 40% reduction in blistering after 4 weeks vs 18% on vehicle.

Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Causes, Treatment Investigated

By May 15, 2018

The multicenter retrospective study (N=377) was conducted to investigate the causes, treatment protocols, and mortality rates of US adults with SJS/TEN.

Can 3-D Printing Create Temporary Prosthesis, Cut Out Prosthodontist?

May 15, 2018

Evaluators were able to match the correct 3-D nose to the corresponding volunteers' photographs in 171 of 175 photographs (97.7%).

Teledermatology Could Expedite Care for Suspected Skin Cancer

May 14, 2018

The researchers found that the mean time to clinical resolution was 9 days with teledermoscopy referral, compared with 35 days with usual care alone.

Adverse Effect of Osteoporosis Drug May Help Treat Hair Loss

By May 11, 2018

Researchers found that a non-immunosuppressant drug originally designed to treat osteoporosis (WAY-316606) targeted the same mechanism by antagonizing SFRP1, and after treating hair follicles with WAY-316606 for 6 days, the authors found enhanced human hair growth.

Eskata Now Available to Treat Raised Seborrheic Keratoses

By May 07, 2018

Eskata is a high-concentration hydrogen peroxide-based topical solution intended for in-office application.

Hyaluronidase Can Remove Hyaluronic Acid Fillers in Cosmetic Dermatology

April 27, 2018

The researchers found that at 4 weeks and 4 months there were significant differences in physician rater assessment for visual detection and palpability between saline and hyaluronidase; this was mirrored by participant self-assessment at 4 weeks and 4 months.

Serlopitant Found to Be Safe, Effective for Chronic Pruritus

April 24, 2018

The decreases from baseline using visual analogue scale pruritus scores were statistically significantly larger with the 1- and 5-mg doses of serlopitant (P=.022 and .013, respectively) versus placebo at week 6.

Vaniqa Cream Currently in Shortage

By April 18, 2018

Vaniqa, a hair growth retardant, is indicated to reduce unwanted facial hair in women.

Endocrine Therapy-Induced Alopecia Seen in Breast Cancer

April 12, 2018

"Endocrine therapies are associated with a pattern alopecia similar to androgenetic-type, consistent with the mechanism of action of causal agents," the authors write.

Hyaluronic Acid Filler Feasible for Correcting Infraorbital Hollows

April 09, 2018

The average time to additional treatment was 35.7 days. Adverse effects included bruising, contour irregularities, swelling, and Tyndall effect, and these occurred in 10, 2, 3, and 1% of patients, respectively.

U.S. Providers Fix Complications From Medical Tourism Procedures

April 09, 2018

The researchers found that among 78 identified patients over a 7-year period, complications were seen following abdominoplasty (35 procedures), breast augmentation (25), and foreign body injections (15).

Microneedling + 5-Fluorouracil Effective Vitiligo Treatment

March 23, 2018

The researchers found that overall repigmentation was significantly higher in the patches treated with 5-fluorouracil compared with tacrolimus. Excellent improvement was seen in 48% of the 5-fluorouracil-treated patches versus 16% of tacrolimus-treated patches.