Miscellaneous Dermatological Conditions
Clinical data has indicated that the drug exhibits a low propensity for resistance development as well as a favorable tolerability profile.
Patients with TGM-1 deficiency may have chronic pronounced scaling of the skin with increased transepidermal water loss, as the TGM-1 enzyme is essential for facilitating the formation of the epidermal barrier, which prevents dehydration.
The Committee's recommendation was based on data from the omadacycline global development program that included nearly 2000 adults in three Phase 3 studies.
"In the case of BBQ fumes, dermal absorption was a more important pathway for intake of low-molecular-weight PAHs than inhalation," the authors write.
Adults with AD reported higher proportions of having only fair/poor overall health, being somewhat/very dissatisfied with life, having lower weighted mean Short-Form 12 (SF-12) mental and physical health subscores, and having higher Dermatology Life Quality Index scores, compared to adults without AD.
The approval was supported by Phase 3 data from the ATMOS-1 and ATMOS-2 trials which evaluated the absolute change from baseline in sweat production after treatment with Qbrexza, and the proportion of patients who achieved ≥4-point improvement from baseline in their sweating severity (as measured by the Axillary Sweating Daily Diary [ASDD]).
In a press release Dr. David Young, CEO of Processa said "We plan to begin our clinical studies in 2018 and to accelerate the development of PCS499 in order to provide clinical benefit to [necrobiosis lipoidica] patients as soon as possible."
The male patient presented in 2009 with a "3-year history of multiple interconnecting comedones in the axilla and inguinal regions, as well as scarring from previous lesions."
The researchers observed clinically meaningful and statistically significant improvement in facial angiofibromas for 1 and 0.1% rapamycin versus vehicle only, and for 1 vs 0.1% rapamycin; most of the improvement was seen in the first month.
The approval was based on data from the Ritux 3 trial (N=90) which compared rituximab + short-term oral prednisone (Ritux 3 regimen) to oral prednisone alone as a first-line treatment for patients with newly diagnosed moderate to severe PV.
This month we look at the issue of whether a physician can be liable for relying on information provided by the patient.
KB103 is a replication-defective, non-integrating viral vector that utilizes the Company's STAR-D platform to deliver functional human COL7A1 genes directly to the patients' dividing and non-dividing skin cells.
The researchers identified 7 studies that used platelet-rich plasma alone for facial rejuvenation, 7 in combination with fat grafting, 2 for treatment of acne scarring, and 6 for treatment of androgenic alopecia.
A previous Phase 2 trial of 17 patients with EBS showed that 60% of those treated with diacerein cream experienced at least a 40% reduction in blistering after 4 weeks vs 18% on vehicle.
The multicenter retrospective study (N=377) was conducted to investigate the causes, treatment protocols, and mortality rates of US adults with SJS/TEN.
Evaluators were able to match the correct 3-D nose to the corresponding volunteers' photographs in 171 of 175 photographs (97.7%).
The researchers found that the mean time to clinical resolution was 9 days with teledermoscopy referral, compared with 35 days with usual care alone.
Researchers found that a non-immunosuppressant drug originally designed to treat osteoporosis (WAY-316606) targeted the same mechanism by antagonizing SFRP1, and after treating hair follicles with WAY-316606 for 6 days, the authors found enhanced human hair growth.
The researchers found that at 4 weeks and 4 months there were significant differences in physician rater assessment for visual detection and palpability between saline and hyaluronidase; this was mirrored by participant self-assessment at 4 weeks and 4 months.
The decreases from baseline using visual analogue scale pruritus scores were statistically significantly larger with the 1- and 5-mg doses of serlopitant (P=.022 and .013, respectively) versus placebo at week 6.
"Endocrine therapies are associated with a pattern alopecia similar to androgenetic-type, consistent with the mechanism of action of causal agents," the authors write.
The average time to additional treatment was 35.7 days. Adverse effects included bruising, contour irregularities, swelling, and Tyndall effect, and these occurred in 10, 2, 3, and 1% of patients, respectively.
The researchers found that among 78 identified patients over a 7-year period, complications were seen following abdominoplasty (35 procedures), breast augmentation (25), and foreign body injections (15).
The researchers found that overall repigmentation was significantly higher in the patches treated with 5-fluorouracil compared with tacrolimus. Excellent improvement was seen in 48% of the 5-fluorouracil-treated patches versus 16% of tacrolimus-treated patches.