Miscellaneous Dermatological Conditions

Rituxan Granted Priority Review for Rare Autoimmune Disease

By February 16, 2018

The disease can be life threatening. Phase 3 study results released last March demonstrated Rituxan substantialy improved pemphigus vulgaris remission rates and successful tapering.

Oral JAK1 Inhibitor Gets Breakthrough Tx Designation for Atopic Dermatitis

By February 15, 2018

In December, a Phase 3, randomized, double-blind, placebo-controlled trial (JADE) was initiated to evaluate the safety and efficacy of PF-04965842 in 375 patients aged ≥12 years with moderate to severe AD.

Efficacy of Omalizumab for Refractory CSU Assessed in Real-World Settings

February 13, 2018

The remaining 3 patients had well-controlled disease after omalizumab treatment. In 30% of patients, the best response to omalizumab was achieved after interval administration of a 9-day course of methylprednisolone (total dose of 188mg)

Topical Nitrates Effective for Treating Raynaud's Phenomenon

By February 09, 2018

A total of 7 trials involving 346 patients were identified; nitroglycerin ointments were used in 4 trials, MQX-503 in 2 trials, and a compounded nitrite in 1 trial.

He Said, She Said: Clinician Sued After Patient Suffers Severe Drug Reaction

By February 07, 2018

It is essential to document warnings, especially significant ones, like this.

Stem Cell Transplant May Be Effective for Systemic Sclerosis

February 07, 2018

The researchers found that, over 7 years of follow-up, there was significant sustained improvement in skin score as well as in vasculopathy and gastrointestinal manifestations.

Tofacitinib + Phototherapy May Be Beneficial for Vitiligo Treatment

February 06, 2018

Case reports describe repigmentation of vitiligo with facial involvement in Hispanic woman, white man

Carboxytherapy vs. Platelet-Rich Plasma for Treating Stretch Marks

January 22, 2018

The fibronectin-stained area from skin biopsies was significantly higher in both groups after treatment compared with before, and it was significantly higher after carboxytherapy compared to PRP.

Combo Treatment Evaluated for Improving Neck Lines and Wrinkles

January 16, 2018

The researchers observed significant improvement in the mean neckline score, from 2.6 (moderate-to-severe lines) at baseline to 1.3 (mild lines) at 90 days after treatment.

Potential First-in-Class Treatment Fast-Tracked for Alopecia Areata

By January 12, 2018

Currently, there are no FDA approved treatments for alopecia areata.

Newborn Treated for Toxoplasmosis With Mother's SJS Causative Agents

By January 10, 2018

Stevens-Johnson syndrome is a severe skin reaction often triggered by certain medications.

Breast Implants Increase Rare Type of Lymphoma

January 05, 2018

"Our results emphasize the need for increased awareness among the public, medical professionals, and regulatory bodies; promotion of alternative cosmetic procedures; and alertness to signs and symptoms of breast-ALCL in women with implants," the authors write.

Spironolactone/Minoxidil Combo Appears Effective for Female Pattern Hair Loss

December 20, 2017

There was an observed 0.85 mean reduction in hair loss severity score at 6 months and a 1.3 mean reduction at 12 months.

Case Study IDs Calciphylaxis Risk Factors, May Aid in Future Prevention

December 14, 2017

The researchers observed significant associations for lupus anticoagulant (48% positive in cases versus 5% in controls), protein C deficiency (50 versus 8%), and combined thrombophilias (62 versus 31%) with calciphylaxis among all patients.

C-Reative Protein Levels and Spontaneous Urticaria: Is There a Link?

December 06, 2017

The researchers found that one-third of patients exhibiting CSU had elevated levels of CRP.

FDA Expands Use of DESCRIBE PFD Patch for Laser Treatment of Tattoos

By December 04, 2017

The Patch, which is placed over tattoos prior to removal with a laser, allows physicians to treat tattoos more efficiently by enabling rapid multiple laser passes in a single treatment session.

Survey Shows Atopic Dermatitis Often Inadequately Controlled

December 01, 2017

The control rate increased with current AD severity and was 53.4% among patients receiving immunosuppressants and 83.4% among patients receiving systemic corticosteroids.

Hidradenitis Suppurativa: Pharmacological and Surgical Txs Reviewed

By November 29, 2017

The authors reported significant disability and comorbidities among patients with HS, including obesity, metabolic syndrome, diabetes, and arthritis.

Sunscreen Ingredient Linked to Dermatological and Environmental Toxicity

November 22, 2017

Increased adverse reactions may be result of closed loop involving ingesting fish, washing ingredient off

Some Prescription-Strength Meds May Be Easily Acquired Over-the-Counter

November 03, 2017

"Dermatologists and primary care physicians should be cognizant of any over-the-counter product that their patients are using," the authors of a JAMA report write.

Rare Disorder Causes Patient to Spontaneously 'Sweat Blood'

By October 24, 2017

During the patient's admission, a bleeding episode occurred which resulted in blood-stained fluid on her face.

Proton Pump Inhibitor Use Linked to Two Distinct Dermatological Reactions

By October 18, 2017

The case involved a 32-year-old male who was prescribed pantoprazole after initially presenting with dyspepsia-like symptoms.

Investigational Hyperhidrosis Therapy Found to Be Safe, Effective

By October 13, 2017

Daily treatment with glycopyrronium tosylate in the Phase 3, open-label ARIDO trial was generally well-tolerated during 44 weeks of treatment.

Has Mass Media Criteria for What Constitutes Beauty Evolved?

October 12, 2017

In 1990, Fitzpatrick skin types I to III represented 88% of the celebrities on the list and Fitzpatrick skin types IV to VI represented 12%; in contrast, in 2017, Fitzpatrick skin types I to III and IV to VI represented 70.4 and 29.6%, respectively

Case: Tattoo Ink-Induced Lymphadenopathy Misdiagnosed as Cancer

October 04, 2017

Case report describes patient with multiple enlarged lymph nodes seen on PET-CT years after tattoo

International Eczema Council Reach Consensus on Corticosteroid Use

September 26, 2017

In specific circumstances, systemic corticosteroids can be used rarely for severe atopic dermatitis, such as lack of other treatment options, as a bridge to other systemic therapies or phototherapy, during acute flares that need immediate relief, in anticipation of a major life event, or in the most severe cases.

Tuberculosis Vaccine May Carry Dermatological Benefits for Newborns

September 25, 2017

There was a significant difference in the effect of neonatal BCG vaccination between children with atopic predisposition and children without atopic predisposition.

Hair Regrowth in Alopecia Patients After Fecal Transplant for Recurrent CDI

By September 22, 2017

These 2 cases suggests that fecal transplants can have a profound immunological response not only limited to intestinal effects, say the authros.

Dupixent Improves Disease Severity, Skin Clearing in Atopic Dermatitis

By September 20, 2017

The data indicated 59% of patients given Dupixent weekly with topical corticosteroids and 63% of patients given Dupixent every 2 weeks with topical corticosteroids achieved EASI-75 vs. 30% of patients given placebo with topical corticosteroids (P<0.0001).

AAP Publish First Guidance on Tattooing, Piercing for Adolescents

By September 18, 2017

These can occur from contamination of the inks or diluents used for tattooing.