METANX Rx

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METANX

Diabetes
Vitamins, minerals, supplements
Only 4 drugs may be compared at once

Generic Name and Formulations:

L-methylfolate calcium (as Metafolin) 3mg, pyridoxal 5'-phosphate 35mg, methylcobalamin 2mg; caps; lactose-, yeast- and gluten-free.

Select therapeutic use:

Indications for METANX:

Adjunct in endothelial dysfunction in patients who present with loss of protective sensation and neuropathic pain associated with diabetic peripheral neuropathy.

Adult:

1 cap twice daily or 2 caps once daily.

Children:

Not recommended.

Warnings/Precautions:

Folic acid may mask pernicious anemia (may be mitigated by B12 component).

Interactions:

Antagonizes levodopa, pyrimethamine, first generation anticonvulsants (eg, carbamazepine, fosphenytoin, phenytoin, phenobarbital, primidone, valproic acid, valproate). May be antagonized by antibiotics, cholestyramine, colchicine, colestipol, metformin, para-aminosalicylic acid, potassium chloride. Folate levels may be decreased by first generation anticonvulsants, lamotrigine, methotrexate, alcohol (in excess), sulfasalazine, L-dopa, methylprednisone, NSAIDs (high dose), pancreatic enzymes, pentamidine, pyrimethamine, smoking, triamterene, trimethoprim, warfarin.

Adverse Reactions:

Paresthesia, somnolence, GI upset, abdominal pain, loss of appetite, headache, polycythemia vera, itching, transitory exanthema, swelling, allergic reactions.

Elimination:

Renal.

Generic Availability:

NO

How Supplied:

Caps—90

METANX 3mg/35mg/2mg capsules (Qty:60)

appx. price $132.00

Indications for METANX:

Adjunct in endothelial dysfunction and/or hyperhomocysteinemia in patients who present with lower extremity ulcerations.

Adult:

1 cap twice daily or 2 caps once daily.

Children:

Not recommended.

Warnings/Precautions:

Folic acid may mask pernicious anemia (may be mitigated by B12 component).

Interactions:

Antagonizes levodopa, pyrimethamine, first generation anticonvulsants (eg, carbamazepine, fosphenytoin, phenytoin, phenobarbital, primidone, valproic acid, valproate). May be antagonized by antibiotics, cholestyramine, colchicine, colestipol, metformin, para-aminosalicylic acid, potassium chloride. Folate levels may be decreased by first generation anticonvulsants, lamotrigine, methotrexate, alcohol (in excess), sulfasalazine, L-dopa, methylprednisone, NSAIDs (high dose), pancreatic enzymes, pentamidine, pyrimethamine, smoking, triamterene, trimethoprim, warfarin.

Adverse Reactions:

Paresthesia, somnolence, GI upset, abdominal pain, loss of appetite, headache, polycythemia vera, itching, transitory exanthema, swelling, allergic reactions.

Elimination:

Renal.

Generic Availability:

NO

How Supplied:

Caps—90

METANX 3mg/35mg/2mg capsules (Qty:60)

appx. price $132.00