Metabolic Disorders

Following Gastric Bypass, Nature of β-Cell Sensitivity May Change

December 11, 2017

During the highest dose of glucose infusion, the GB subjects had relative hyperglycemia associated with significantly reduced β-cell glucose sensitivity throughout both step-up

Link Between Obesity and Rosacea Examined for First Time

December 11, 2017

The risk for rosacea was higher among those with increased body mass index (BMI; P<0.0001).

Early Treatment With Kalydeco Investigated in Young Cystic Fibrosis Patients

By December 08, 2017

Sweat chloride, a diagnostic characteristic of CF, was also considerably reduced with ivacaftor treatment. Median baseline sweat chloride levels were 104.1mmol/L.

Seven Year Weight Loss Examined for Roux-en-Y, Laparoscopic Bariatric Sx

December 07, 2017

The researchers found that the mean weight loss was 38.2kg or 28.4% of baseline weight at 7 years after RYGB; mean weight regain was 3.9% between years 3 and 7.

Obesity Tied to All-Cause Mortality in HF With Preserved Ejection Fraction

November 28, 2017

Data were included for 3,310 patients with HFpEF: 2,413 with abdominal obesity and 897 patients without abdominal obesity.

Cinnamon May Activate Thermogenesis, Help Combat Obesity

November 27, 2017

The researchers found that in murine primary adipocytes, CA significantly activated PKA signaling, increased expression levels of thermogenic genes, and induced phosphorylation of hormone-sensitive lipase and protein perilipin 1.

Mepsevii Approved to Treat Rare Genetic Disease

By November 16, 2017

Mepsevii (vestronidase alfa-vjbk) was evaluated by the FDA with Priority Review.

CPAP vs. Gastric Band for Severe Sleep Apnea

November 09, 2017

The researchers found that LGB was associated with a greater drop in BMI. In intention-to-treat analyses, the effective apnea-hypopnea index (AHI) at nine months was 29.5 and 20 events/hour in the LGB and CPAP groups, respectively (P=0.02), while at 18 months, the effective AHI was 20.9 and 21.4 events/hour, respectively.

Tezacaftor-Ivacaftor, Ivacaftor Monotherapy Examined in Cystic Fibrosis

November 07, 2017

The researchers found that the effects on the absolute and relative changes in the percentage of the predicted FEV1 were 4 and 6.8%, respectively, in favor of tezacaftor-ivacaftor over placebo.

Elevated GLP-1 After Gastric Bypass May Improve Satiety

November 02, 2017

After Roux-en-Y, CNS activation reduced in response to food cues, GLP-1 levels significantly elevated We hypothesized that postoperative elevated GLP-1 levels contribute to the improved satiety regulation after RYGB via effects on the CNS.

Obesity Treatments

October 27, 2017

A comparative list of medications by pharmacological class for the treatment of obesity.

Probiotic Use Linked to Weight Reduction in Obese and Overweight Patients

October 27, 2017

The researchers found that, compared with placebo, probiotic administration resulted in a significantly larger reduction in body weight, BMI, and fat percentage.

Pompe Disease Treatment Granted Orphan Drug Designation

By September 25, 2017

ATB200 is a unique recombinant human acid alpha-glucosidase (rhGAA) enzyme with optimized carbohydrate structures while AT2221 is a pharmacological chaperone.

Increased Med Use Over Time Seen in Older Patients of All BMI Classes

By September 22, 2017

Researchers aimed to determine whether the rise in prescription drug use over time varied by age and obesity status.

Safety, Effectiveness of Cryolipolysis for Noninvasive Reduction of Fat

September 22, 2017

The researchers found that the mean reduction measured by skin fold caliper was 33% (3.2 mm; P=0.05), and by magnetic resonance imaging, the mean reduction was 1.78mm.

Long-Term Outcomes of Roux-en-Y Gastric Bypass

September 21, 2017

The researchers found that the adjusted mean changes from baseline in body weight in the surgery group were −45.0, −36.3, and −35.0 kg at 2, 6, and 12 years, respectively.

Weight May Play Role in Selecting Treatment Strategy for Breast CA Patients

September 20, 2017

BMI was positively correlated with ER+/PR+ and ER−/PR− subtype risks, with a significant association only seen for ER+/PR+ subtypes.

Investigational Skin Patch Delivers Fat-Burning Drug to Targeted Areas

By September 15, 2017

The patches mechanism of action turns white adipose tissue into brown adipose tissue, white tissue is known to store fat while brown tissue is known to burn fat to produce heat.

Stress, Sleep, Obesity Connection Explored in New Study

September 05, 2017

Stress linked to impaired sleep, increased emotional rewarding of palatable foods, leading to obesity

Reduced Dosing Option Approved for Orfadin in HT-1

By September 05, 2017

The approval of the once-daily dosing option was based on a clinical study that compared a 4-week once-daily regimen to a 4-week twice daily regimen.

Tezacaftor/Ivacaftor Gets Priority Review for Cystic Fibrosis

By August 25, 2017

The FDA has granted Priority Review to the New Drug Application (NDA) of tezacaftor/ivacaftor (Vertex) for the treatment of patients ≥12yrs old with cystic fibrosis (CF) who have two copies of the F508del mutation or one F508del mutation and one residual function mutation.

Exendin Assessed for Post-Bariatric Complications

August 11, 2017

The postprandial glucose nadir was increased by 66%, peak insulin was reduced by 57%, and neuroglycopenic symptoms were reduced by 80%, on average.

FDA: Deaths Following Intragastric Balloon Placement for Obesity

By August 10, 2017

Two additional reports of death within the same time period may possibly be related to balloon placement as well.

Significant Associations Found Between Religiosity and Body Weight

August 07, 2017

The researchers found that for religious affiliation there were significant associations with body weight in both cross-sectional and longitudinal studies.

Treatment Shows Efficacy in Binge Eating Disorder

August 04, 2017

In both studies, more participants on LDX versus placebo were categorized as improved on the Clinical Global Impressions-Improvement starting at week one.

New Treatment Option for Hereditary Tyrosinemia Type 1 Approved

By August 01, 2017

The safety and efficacy of Nityr have been established based on studies of another oral formulation of nitisinone in patients with HT-1.

FDA Approves Kalydeco to Treat More Patients with Cystic Fibrosis

By August 01, 2017

Today's FDA approval follows the Agency's recent approval for 23 other residual function mutations based on in vitro data.

Serum &#947;-Glutamyltransferase Levels May ID MetS in Children

July 28, 2017

After adjustment for age, household income, and residential area, the multivariable-adjusted odds ratios for MetS for the upper stratum were 5.79 and 6.20 in boys and girls, respectively.

'Overfat' Pandemic Grows Even as Obesity Rates Level Off

July 25, 2017

Traditional methods of measuring weight or body mass index are ineffective in assessing whether a person is overfat, the study authors said.

Weight Gain During Adulthood Ups Risk of Major Chronic Diseases

July 20, 2017

As little as 11 pounds gained from early to middle adulthood tied to significantly elevated risk