MERIDIA
Generic Name for MERIDIA
Sibutramine HCl monohydrate 5mg, 10mg, 15mg; caps.
Legal Classification:
CIV
Pharmacological Class for MERIDIA
Mixed neurotransmitter reuptake inhibitor.
Manufacturer of MERIDIA
Abbott Laboratories
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Indications for MERIDIA
Adjunct to diet in the management of obesity in patients with initial body mass index ≥30kg/m2, or ≥27kg/m2 in presence of other risk factors.
Adult dose for MERIDIA
≥16years: Initially 10mg once daily. After 4 weeks, may titrate to 15mg once daily.
Children's dosing for MERIDIA
<16years: not recommended.
Contraindications for MERIDIA
History of coronary artery disease (eg, angina, MI), CHF, tachycardia, arrhythmias, cerebrovascular (eg, stroke, TIA) or peripheral arterial occlusive disease. Inadequately controlled hypertension >145/90mm Hg. Over 65 years of age. During or within 2 weeks of MAOIs (eg, phenelzine, selegiline) or concomitant centrally-acting appetite suppressants. Anorexia or bulimia nervosa.
Precautions for MERIDIA
Exclude organic causes of obesity. Severe renal or hepatic dysfunction: not recommended. Do initial BP and pulse; monitor regularly during therapy; consider discontinuing or reducing dose for patients with sustained increases in either BP or pulse. Seizures (discontinue if occur). Hypertension. Narrow-angle glaucoma. Bleeding disorders. Elderly. Pregnancy (Cat.C), nursing mothers: not recommended.
Interactions for MERIDIA
See Contraindications. Avoid other serotonergic drugs (eg, SSRIs, venlafaxine); monitor if used together; possible serotonin syndrome with these and with sumatriptan, dihydroergotamine, some opioids (eg, dextromethorphan, meperidine, pentazocine, fentanyl), lithium, or tryptophan. Caution with other CNS-active drugs or drugs that can raise BP or pulse (eg, decongestants). Possible interaction with ketoconazole, erythromycin, others metabolized by CYP3A4. Excessive alcohol: not recommended. Caution with oral anticoagulants, platelet inhibitors.
Adverse Reactions for MERIDIA
Dry mouth, anorexia, insomnia, constipation, headache, increased appetite, dizziness, nervousness, GI upset, gallstones, increased BP and/or pulse, mydriasis, others.
How is MERIDIA supplied?
Caps—30