VAGIFEM
Generic Name for VAGIFEM
Estradiol (as hemihydrate) 10micrograms; vaginal tabs.
Legal Classification:
Rx
Pharmacological Class for VAGIFEM
Estrogen.
Manufacturer of VAGIFEM
Novo Nordisk
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Indications for VAGIFEM
Atrophic vaginitis.
Adult dose for VAGIFEM
1 tab intravaginally once daily for 2 weeks, then 1 tab twice weekly. Reevaluate periodically.
Children's dosing for VAGIFEM
Not recommended.
Contraindications for VAGIFEM
Breast or estrogen-dependent carcinoma. Undiagnosed abnormal vaginal bleeding. Thromboembolic disorders (eg, stroke or MI, DVT, pulmonary embolism). Thrombophlebitis. Liver dysfunction or disease. Pregnancy (Cat.X).
Warnings/Precautions for VAGIFEM
See literature. Endometrial hyperplasia. Gallbladder disease. Do initial complete physical and repeat annually (include BP, mammogram, Pap smear). Severely atrophic vaginal mucosa or other trauma risk. Familial hyperlipoproteinemia. Discontinue if severe hypercalcemia, loss of vision, severe hypertriglyceridemia, or cholestatic jaundice occurs, and 2 weeks before surgery associated with thromboembolism. Monitor thyroid function. Nursing mothers.
Interactions for VAGIFEM
May be antagonized by CYP3A4 inducers (eg, St. John's Wort, phenobarbital, carbamazepine, rifampin). May be potentiated by CYP3A4 inhibitors (eg, erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir, grapefruit juice).
Adverse Reactions for VAGIFEM
See literature. Upper respiratory tract infection, headache, abdominal pain, back pain, genital pruritus, moniliasis, vulvovaginal mycotic infection, diarrhea; increased risk of gallbladder disease, thromboembolic disorders.
How is VAGIFEM supplied?
Vaginal tabs—8, 18 (w. applicators)
Related Disease:
Menopausal disorders
Recent Updates
25microgram dosage discontinued.