Menopause And HRT

Cancer, CV Risks Examined for Vaginal Estrogen Tx in Postmenopausal Women

By August 16, 2017

The data showed women with an intact uterus did not have a significantly different risk of stroke, invasive breast cancer, colorectal cancer, endometrial cancer, and pulmonary embolism/deep vein thrombosis (PE/DVT) between those who used vaginal estrogen and those who did not.

Novel Treatment for Dyspareunia Due to Menopause Now Available

By July 24, 2017

Intrarosa contains prasterone, an inactive precursor that is converted locally into estrogens and androgens (with minimal systemic exposure) to help restore vaginal tissue.

Can Estrogen Exposure Affect Depression Risk in Early Post Menopausal Years?

July 24, 2017

Researchers included 1,306 regularly menstruating premenopausal women, aged 42 to 52 years at study entry

NAMS: New Position Statement on Hormone Therapy

By June 20, 2017

Firstly, NAMS reiterates that HT should be individualized for each patient and requires periodic reevaluation for risks and benefits of selected therapy.

Higher Alcohol Intake May Up Muscle Loss, Function for Some Women

By June 07, 2017

The data showed sarcopenia was 4 times more prevalent for the high-risk alcohol drinking group vs. the low-risk alcohol drinking group (odds ratio 4.29, 95% CI: 1.87, 9.82).

Menopausal Age May Correlate With Heart Failure Risk, Incidence

May 16, 2017

The investigators found that earlier menopause was associated with increased risk of heart failure, and this link was stronger in women who had natural rather than surgical menopause.

HRT May Up Hearing Loss Risk in Postmenopausal Women

May 16, 2017

Older age at menopause also appears to increase the risk

Early Hot Flashes May Indicate Presence of Comorbidities

April 17, 2017

The researchers found the associations of hot flashes to be independent of other cardiovascular disease risk factors.

Bio-Identical Combo Therapy Promising for Vasomotor Symptoms of Menopause

By April 04, 2017

TherapeuticsMD announced positive data for its investigational hormone therapy, TX-001HR, for the treatment of moderate to severe vasomotor symptoms (VMS) due to menopause. Study findings were presented at the annual meeting of the Endocrine Society, ENDO 2017.

Neurokinin 3 Receptor Antagonism for Menopausal Hot Flushes

By April 03, 2017

Prague JK, et al. "Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double-blind, placebo-controlled trial"

Estriol Gel Investigated Post-Genital Prolapse Sx

March 31, 2017

The researchers found that the group receiving estriol gel had improvement in all aspects of vaginal health before surgery versus baseline .

Vit D Levels May Correlate With Overall Survival in Breast CA

By March 24, 2017

The researchers found that the overall survival was strongest among premenopausal women in the highest 25OHD tertile group.

Hormone Therapy and Alzheimer's Disease: What's the Link?

February 17, 2017

Researchers found that their evidence showed no protective association between postmenopausal HT use and AD or dementia, although they observed a reduced AD risk among those with long-term self-reported HT use.

Certain Pain Meds May Have Significant Endocrinologic Effects

By February 10, 2017

Chronic pain patients being treated with certain opioid and non-opioid medications had significantly lower serum concentrations of free testosterone (fTe) and free estradiol (fE2), highlighting the potential endocrinologic side effects of these drugs. These were the findings of a new study published in the journal Drug Testing and Analysis.

Hormone ID'd as Predictor of Menopause in Women With HIV

January 23, 2017

For HIV-infected women, anti-müllerian hormone is associated with age of menopause onset, according to a study published in the January issue of the American Journal of Obstetrics & Gynecology.

Lung Function Decline Linked to Menopause

December 07, 2016

Menopausal status is associated with accelerated lung function decline, according to a study published online in the American Journal of Respiratory and Critical Care Medicine.

FDA Approves Intrarosa for the Treatment of Dyspareunia

By November 17, 2016

The FDA has approved Intrarosa (prasterone; Endoceutics) for the treatment of women experiencing moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause.

Does Fracture Risk Go Up After Stopping Hormone Therapy?

By November 08, 2016

For women who are former hormone therapy users, risk of fracture is not increased after discontinuing therapy, according to a study published in the The Journal of Clinical Endocrinology & Metabolism.

Recall of Estrogen Tabs Announced

By October 31, 2016

Pfizer announced a voluntary recall of one lot of Premarin (conjugated estrogens) 1.25mg tablets due to an incorrect expiration date applied to the bottle label.

Yuvafem Available for Atrophic Vaginitis

By October 18, 2016

Amneal announced the availability of Yuvafem (estradiol vaginal inserts), a generic version of Vagifem.

Menest Dosage Strength Discontinued

By October 13, 2016

The Food and Drug Administration (FDA) reports the discontinuation of Menest (esterified estrogens; Pfizer) 2.5mg tablets.

Fracture Risk Examined in Postmenopausal Women Using Romosozumab

September 19, 2016

For postmenopausal women with osteoporosis, romosozumab is associated with reduced risk of vertebral fracture at 12 months

Prometrium Capsules Now Available

By August 01, 2016

Virtus has announced the launch of Prometrium (progesterone USP capsule).

Nanopause Bolero Available to Relieve Menopause Symptoms

By July 21, 2016

Nanohealth announced the launch of the nanopause Bolero, a non-hormone product cleared by the Food and Drug Administration (FDA) to relieve symptoms of menopause such as hot flashes and night sweats.

Estradiol Effects on Cognition Examined After Menopause

July 21, 2016

Improvement in cognitive ability is not associated with estrogen therapy among women who use it after menopause, no matter when they start taking it, according to a study published online in Neurology.

Does Reducing Caffeine Intake Help Prevent PMS?

By July 19, 2016

Decreasing caffeine intake may not help women prevent premenstrual syndrome (PMS), a team of researchers reported.

Paroxetine for Vasomotor Symptoms: Does Evidence Support Use?

April 19, 2016

Moderate quality evidence shows reduction in frequency of hot flashes with paroxetine

Risk of Stroke May Persist After Discontinuing Estrogen-Only HRT

By April 17, 2016

Unopposed estrogen hormone replacement therapy (HRT) significantly increases the risks for ischemic strokes when compared to combination estrogen and progesterone HRT, even after it is discontinued.

Study Suggests Hormone Tx a Safe Option After Nonserous Epithelial Ovarian CA

April 08, 2016

For women with nonserous epithelial ovarian cancer, hormone therapy (HT) after treatment does not reduce survival, according to a study published in the May issue of Obstetrics & Gynecology.

Radius Submits NDA for New Osteoporosis Tx in Postmenopausal Women

By April 01, 2016

Radius Health announced the submission of a New Drug Application (NDA) to the Food and Drug Administration (FDA) for abaloparatide-subcutaneous (SC) 80mg, a once daily treatment for postmenopausal women with osteoporosis.