Menopause And HRT

USPSTF Updates Recommendation on Menopausal Hormone Therapy

December 12, 2017

Based on these findings, the USPSTF concluded that for most postmenopausal women with an intact uterus, combined estrogen and progestin had no net benefit for primary prevention of chronic conditions (D recommendation).

Postmenopausal Estradiol May Protect Against Effects of Stress

November 03, 2017

The researchers found that the women assigned to estradiol exhibited blunted cortisol responses to CPT compared with the women in the placebo group (P=0.017) and lesser negative effects of stress on working memory (P=0.048).

CombiPatch, Minivelle Patches No Longer in Shortage

By October 03, 2017

Noven announced that CombiPatch (estradiol/norethindrone acetate transdermal system) and Minivelle (estradiol transdermal system) are now readily available following a temporary product shortage.

Hormone Tx During Menopause and Mortality Rate: Is There a Link?

September 13, 2017

The researchers found that during the 18-year follow-up, there were 7,489 deaths (1,088 deaths during the intervention phase and 6,401 deaths during postintervention follow-up).

Non-Hormone Options Recommended for Depletion After Breast CA

August 30, 2017

The researchers recommend that women should not generally be treated with menopausal hormone therapy or tibolone following breast cancer, but should optimize lifestyle.

Licorice Supplements May Put Patients at Risk for Drug Interactions

By August 22, 2017

More women are looking toward alternatives like licorice due to, "concerns about the risk of stroke and breast cancer associated with conventional hormone," said Richard B. van Breemen, PhD, and lead author.

Cancer, CV Risks Examined for Vaginal Estrogen Tx in Postmenopausal Women

By August 16, 2017

The data showed women with an intact uterus did not have a significantly different risk of stroke, invasive breast cancer, colorectal cancer, endometrial cancer, and pulmonary embolism/deep vein thrombosis (PE/DVT) between those who used vaginal estrogen and those who did not.

Teva Launches Generic Vagifem

By July 26, 2017

Local estrogen therapy has been shown to restore vaginal pH and resvascularize the vaginal and urethral mucosa, improving vaginal dryness and mucosal atrophy.

Novel Treatment for Dyspareunia Due to Menopause Now Available

By July 24, 2017

Intrarosa contains prasterone, an inactive precursor that is converted locally into estrogens and androgens (with minimal systemic exposure) to help restore vaginal tissue.

Can Estrogen Exposure Affect Depression Risk in Early Post Menopausal Years?

July 24, 2017

Researchers included 1,306 regularly menstruating premenopausal women, aged 42 to 52 years at study entry

NAMS: New Position Statement on Hormone Therapy

By June 20, 2017

Firstly, NAMS reiterates that HT should be individualized for each patient and requires periodic reevaluation for risks and benefits of selected therapy.

Higher Alcohol Intake May Up Muscle Loss, Function for Some Women

By June 07, 2017

The data showed sarcopenia was 4 times more prevalent for the high-risk alcohol drinking group vs. the low-risk alcohol drinking group (odds ratio 4.29, 95% CI: 1.87, 9.82).

Menopausal Age May Correlate With Heart Failure Risk, Incidence

May 16, 2017

The investigators found that earlier menopause was associated with increased risk of heart failure, and this link was stronger in women who had natural rather than surgical menopause.

HRT May Up Hearing Loss Risk in Postmenopausal Women

May 16, 2017

Older age at menopause also appears to increase the risk

Early Hot Flashes May Indicate Presence of Comorbidities

April 17, 2017

The researchers found the associations of hot flashes to be independent of other cardiovascular disease risk factors.

Bio-Identical Combo Therapy Promising for Vasomotor Symptoms of Menopause

By April 04, 2017

TherapeuticsMD announced positive data for its investigational hormone therapy, TX-001HR, for the treatment of moderate to severe vasomotor symptoms (VMS) due to menopause. Study findings were presented at the annual meeting of the Endocrine Society, ENDO 2017.

Neurokinin 3 Receptor Antagonism for Menopausal Hot Flushes

By April 03, 2017

Prague JK, et al. "Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double-blind, placebo-controlled trial"

Estriol Gel Investigated Post-Genital Prolapse Sx

March 31, 2017

The researchers found that the group receiving estriol gel had improvement in all aspects of vaginal health before surgery versus baseline .

Vit D Levels May Correlate With Overall Survival in Breast CA

By March 24, 2017

The researchers found that the overall survival was strongest among premenopausal women in the highest 25OHD tertile group.

Hormone Therapy and Alzheimer's Disease: What's the Link?

February 17, 2017

Researchers found that their evidence showed no protective association between postmenopausal HT use and AD or dementia, although they observed a reduced AD risk among those with long-term self-reported HT use.

Certain Pain Meds May Have Significant Endocrinologic Effects

By February 10, 2017

Chronic pain patients being treated with certain opioid and non-opioid medications had significantly lower serum concentrations of free testosterone (fTe) and free estradiol (fE2), highlighting the potential endocrinologic side effects of these drugs. These were the findings of a new study published in the journal Drug Testing and Analysis.

Hormone ID'd as Predictor of Menopause in Women With HIV

January 23, 2017

For HIV-infected women, anti-müllerian hormone is associated with age of menopause onset, according to a study published in the January issue of the American Journal of Obstetrics & Gynecology.

Lung Function Decline Linked to Menopause

December 07, 2016

Menopausal status is associated with accelerated lung function decline, according to a study published online in the American Journal of Respiratory and Critical Care Medicine.

FDA Approves Intrarosa for the Treatment of Dyspareunia

By November 17, 2016

The FDA has approved Intrarosa (prasterone; Endoceutics) for the treatment of women experiencing moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause.

Does Fracture Risk Go Up After Stopping Hormone Therapy?

By November 08, 2016

For women who are former hormone therapy users, risk of fracture is not increased after discontinuing therapy, according to a study published in the The Journal of Clinical Endocrinology & Metabolism.

Recall of Estrogen Tabs Announced

By October 31, 2016

Pfizer announced a voluntary recall of one lot of Premarin (conjugated estrogens) 1.25mg tablets due to an incorrect expiration date applied to the bottle label.

Yuvafem Available for Atrophic Vaginitis

By October 18, 2016

Amneal announced the availability of Yuvafem (estradiol vaginal inserts), a generic version of Vagifem.

Menest Dosage Strength Discontinued

By October 13, 2016

The Food and Drug Administration (FDA) reports the discontinuation of Menest (esterified estrogens; Pfizer) 2.5mg tablets.

Fracture Risk Examined in Postmenopausal Women Using Romosozumab

September 19, 2016

For postmenopausal women with osteoporosis, romosozumab is associated with reduced risk of vertebral fracture at 12 months

Prometrium Capsules Now Available

By August 01, 2016

Virtus has announced the launch of Prometrium (progesterone USP capsule).