Melanoma And Other Skin Cancers

FDA Expands Yervoy Use for Pediatric Melanoma

By July 24, 2017

A population pharmacokinetic analysis (n=565) showed that Yervoy exposure in patients aged ≥12 years was similar to that in adults at the approved 3mg/kg dose given intravenously (IV) over 90 minutes every 3 weeks for a total of doses.

The Fruit That May Help Protect Skin From UV-Induced Damage

July 19, 2017

Compared to controls, the researchers found that male mice consuming red tomato diets or pooled tomato diets had significantly lower tumor number (1.73 ± 0.50 and 2.03 ± 0.45, respectively, versus 4.04 ± 0.65).

Strong Link Identified Between Parkinson's and Melanoma

July 11, 2017

The researchers found that, compared with controls, patients with Parkinson's disease had a 3.8-fold increased likelihood of having preexisting melanoma, while patients with melanoma had a 4.2-fold increased risk of developing Parkinson's disease.

Efficacy of Melanoma Tx Assessed Beyond Progression

July 05, 2017

The researchers found that 58% of the 526 randomized patients experienced disease progression, including 28 and 72% in the TBP and non-TBP groups.

FDA Approves Combo Tx for Metastatic NSCLC with BRAF V600E Mutation

By June 23, 2017

The approval for Tafinlar and Mekinist combination therapy was based on a Phase 2 international, multicenter, 3-cohort, non-randomized, non-comparative, open-label trial (Study BRF113928) in patients with locally confirmed stage IV NSCLC with BRAF V600E mutation.

PDE5 Inhibitors and Melanoma: What's the Risk?

By May 19, 2017

The association between melanoma among PDE5i users was only statistically significant for male patients with low PDE5i exposure and with low-stage melanoma.

Visuals Work in Discouraging Indoor Tanning

May 02, 2017

A total of 568 undergraduate females were randomized to either 1 of 3 message conditions visually depicting health effects, appearance damage, or immediate risks, or to a text-only control.

Childhood Survivors May be Predisposed to Cancer Later in Life

April 05, 2017

More than one-quarter of patients who survived childhood cancer had developed another cancer by the age of 45.

Psoriasis May Up Melanoma, Hematologic Cancer Risk

March 28, 2017

The researchers found that patients with psoriasis had 1.53 times greater risk of developing a malignancy versus patients without psoriasis (P<0.01).

Bavencio Approved for Rare Skin Cancer

By March 23, 2017

The accelerated approval was based on data from a single-arm study (n=88) in patients with metastatic MCC who were treated with at least one prior chemotherapy regimen.

Massage Improves Pain, Lymphedema in Female CA Patients

March 10, 2017

The researchers found that all participants reported a positive experience with aromatherapy massage.

'Sizable Portion' of Melanoma Survivors Show Lax Attitude to UV Protection

March 03, 2017

A sizeable proportion of melanoma survivors still report elevated sun exposure, sunburns, and suboptimal ultraviolet radiation protection behaviors, according to research published online March 2 in Cancer Epidemiology, Biomarkers & Prevention.

Indoor Tanning Significant Contributor to Illness, Premature Death

March 01, 2017

Skin cancers from ultraviolet light in devices totaled 343.1 million in 2015 alone, researchers say

FDA Grants Opdivo Accelerated Approval For Urothelial Carcinoma

By February 03, 2017

The FDA has approved Opdivo (nivolumab; Bristol-Myers Squibb) for the treatment of patients with locally advanced or metastatic urothelial carcinoma who have disease progression during or after platinum-based chemotherapy or for those who have disease progression within 12 months of neoadjuvant or adjuvant platinum-based chemotherapy.

FDA: Multiple Pet Fatalities After Exposure to Human Topical Drug

By January 19, 2017

Clinicians and pharmacists who prescribe and fill medications containing the drug are advised to inform patients to avoid exposure to pets.

Has Earlier Melanoma Detection Affected Mortality Rates?

December 22, 2016

The burden of melanoma is increasing in the United States, according to a research letter published online in JAMA Dermatology.

Therapy Suggestions Inconsistent Among Pathologists, Study Finds

December 20, 2016

Pathologists have wide variability in treatment suggestions for melanocytic lesions, according to a study published in the January issue of the Journal of the American Academy of Dermatology.

Prognostic Biomarkers ID'd in Cutaneous SCC

December 20, 2016

MicroRNAs (miR-203 and miR-205) could be useful prognostic markers in cutaneous squamous cell carcinoma, with distinct expression and associations.

Imiquimod vs. Surgery Outcomes in Basal Cell Carcinoma

December 16, 2016

For superficial or nodular basal cell carcinoma at low-risk sites, imiquimod has lower treatment success rates than surgery but the benefit is sustained at five years, according to a study published online December 5 in the Journal of Investigative Dermatology.

Alcohol Intake Associated with Modest Increase in Melanoma Risk

December 02, 2016

Correlation stronger for melanoma in relatively UV-spared sites versus UV-exposed sites

Priority Review Given to Metastatic Merkel Cell Carcinoma Agent

By November 30, 2016

Merck and Pfizer announced that the Food and Drug Administration (FDA) has accepted for Priority Review the Biologics License Application (BLA) for avelumab to treat metastatic Merkel cell carcinoma.

Benefits of Tailoring Melanoma Screening Via Clinical Features

November 11, 2016

Certain patients at high risk of melanoma may benefit from more tailored skin exams, according to a study published in JAMA Dermatology.

Immunotherapy for Melanoma: Why Gut Bacteria May Be Key

By November 07, 2016

Having greater gut bacteria diversity may indicate a greater response to immunotherapy treatment in patients with malignant melanoma, according to new research conducted by scientists at the University of Texas MD Anderson Cancer Center.

Potentially Fatal T-Cell Reaction ID'd in Melanoma Combo Treatment

November 03, 2016

Patients with melanoma treated with a combination of ipilimumab and nivolumab may be at risk for a potentially fatal T-cell-driven drug reaction, according to a report published in the New England Journal of Medicine.

Topical Imiquimod Examined for Regression in Lentigo Maligna

October 21, 2016

For patients with lentigo maligna (LM) in-situ melanoma, topical imiquimod has a pathological complete regression (pCR) rate of 37%, according to a study published online in the British Journal of Dermatology.

Significant PFS Improvement With Combo Tx in Melanoma Study

By September 26, 2016

Array BioPharma and Pierre Fabre announced top-line data from part 1 of the Phase 3 COLUMBUS study evaluating LGX818 (encorafenib) and MEK162 (binimetinib) in patients with BRAF-mutant advanced, unresectable or metastatic melanoma.

Organ Transplants and Incidence of Skin Cancer in Nonwhite Patients

September 22, 2016

Patients who have an organ transplant may be more likely to develop skin cancer, and that applies to all transplant patients, even those who are nonwhite and dark-skinned, according to research published online Sept. 21 in JAMA Dermatology.

FDA Modifies Dosing Regimen for Nivolumab

By September 15, 2016

The Food and Drug Administration (FDA) has approved a modification to the nivolumab (Opdivo; Bristol-Myers Squibb) dosage regimen for renal cell carcinoma, metastatic melanoma, and non-small cell lung cancer.

Study Examines Best Indications for Reflectance Confocal Microscopy

September 06, 2016

Reflectance confocal microscopy (RCM) best identifies skin cancer lesions on the head and neck, and RCM morphologic patterns differ for distinct melanomas, according to two studies published online August 31 in JAMA Dermatology.

Potential Treatment for Melanoma Under FDA Review

By September 01, 2016

The Food and Drug Administration (FDA) has accepted for review the New Drug Application (NDA) for binimetinib (Array BioPharma) for the treatment of NRAS-mutant melanoma.