Melanoma And Other Skin Cancers

Guidelines of Care Issued for Management of Skin Cancer

January 22, 2018

The guidelines address biopsy techniques and histopathologic assessment, staging of tumors, surgical and nonsurgical management, follow-up, prevention of recurrence, and advanced disease management.

Tumor Responses to PD-1 Blockade Assessed in Desmoplastic Melanoma

January 17, 2018

The percentage of PD-L1-positive cells was higher in the tumor parenchyma in desmoplastic melanomas than in non-desmoplastic melanomas (P=0.04).

HCTZ Use Linked to Increased Risk of Non-Melanoma Skin Cancer

January 08, 2018

Researchers found an inncreased risk for basal cell carcinoma, squamous cell carcinoma, with dose-response relationship.

Opdivo Approved as Adjuvant Tx for Patients With Melanoma

By December 21, 2017

The major efficacy outcome measure was RFS, defined as the time between the randomization date and the date of first recurrence (local, regional, or distant metastasis), new primary melanoma, or death from any cause, whichever occurs first.

First Dose-Escalation Study Examines Ulixertinib for Advanced Tumors

December 18, 2017

The researchers found that ulixertinib exposure was dose-proportional to the RP2D and almost completely inhibited ERK activity in whole blood.

Effectiveness of Vermilionectomy in SCC and AC of the Lower Lip Investigated

December 15, 2017

SCC was revealed accompanying AC in 14 patients in postoperative biopsy; four patients in the AC-only group had SCC in situ.

Patidegib Gets Breakthrough and Orphan Designation for Gorlin Syndrome

By November 20, 2017

Gorlin Syndrome is a rare, genetic disease characterized by mutations in the tumor suppressor gene encoding Patched1.

USPSTF Issues Draft Recommendation on Counseling to Prevent Skin Cancer

October 11, 2017

The researchers recommend that clinicians provide counseling on sun protection behaviors for anyone with fair skin aged 6 months to 24 years, including parents of young children with fair skin (B recommendation).

Can β-Blocker Use Protect Against Melanoma Recurrence?

September 29, 2017

The researchers found that the use of propranolol at the time of diagnosis was significantly inversely linked to melanoma recurrence after adjustment for known prognostic factors, with about an 80% reduction in risk for propranolol users.

BRAF, MEK Inhibitor Combo Assessed in Resected Melanoma

September 13, 2017

The researchers found that the estimated 3-year rate of relapse-free survival was 58% in the combination-therapy group and 39% in the placebo group at a median follow-up of 2.8 years.

Nivolumab vs. Ipilimumab as Adjuvant Tx in Resected Advanced Melanoma

September 12, 2017

The researchers found that the 12-month rate of recurrence-free survival was 70.5 and 60.8% in the nivolumab and ipilimumab groups, respectively, at a minimum follow-up of 18 months.

Anti-PD-1 Therapy Tied to Neurological Adverse Events

September 11, 2017

The researchers found that 2.9% of the 347 patients treated with anti-PD-1 monoclonal antibodies developed subacute onset of neurological complications.

Cemiplimab Gains Breakthrough Tx Designation for Advanced Skin Cancer

By September 08, 2017

A Phase 2, single-arm, open-label clinical trial, EMPOWER-CSCC 1, is now enrolling patients with metastatic CSCC and locally advanced and unresectable CSCC.

Fruit Flavonol May Have Protective Effects on UV-Induced Skin Damage

August 24, 2017

The researchers found that, as determined by the cell viability assay, ultraviolet (UV)-induced keratinocyte death was attenuated by myricetin in a dose-dependent manner.

FDA Expands Yervoy Use for Pediatric Melanoma

By July 24, 2017

A population pharmacokinetic analysis (n=565) showed that Yervoy exposure in patients aged ≥12 years was similar to that in adults at the approved 3mg/kg dose given intravenously (IV) over 90 minutes every 3 weeks for a total of doses.

The Fruit That May Help Protect Skin From UV-Induced Damage

July 19, 2017

Compared to controls, the researchers found that male mice consuming red tomato diets or pooled tomato diets had significantly lower tumor number (1.73 ± 0.50 and 2.03 ± 0.45, respectively, versus 4.04 ± 0.65).

Strong Link Identified Between Parkinson's and Melanoma

July 11, 2017

The researchers found that, compared with controls, patients with Parkinson's disease had a 3.8-fold increased likelihood of having preexisting melanoma, while patients with melanoma had a 4.2-fold increased risk of developing Parkinson's disease.

Efficacy of Melanoma Tx Assessed Beyond Progression

July 05, 2017

The researchers found that 58% of the 526 randomized patients experienced disease progression, including 28 and 72% in the TBP and non-TBP groups.

FDA Approves Combo Tx for Metastatic NSCLC with BRAF V600E Mutation

By June 23, 2017

The approval for Tafinlar and Mekinist combination therapy was based on a Phase 2 international, multicenter, 3-cohort, non-randomized, non-comparative, open-label trial (Study BRF113928) in patients with locally confirmed stage IV NSCLC with BRAF V600E mutation.

PDE5 Inhibitors and Melanoma: What's the Risk?

By May 19, 2017

The association between melanoma among PDE5i users was only statistically significant for male patients with low PDE5i exposure and with low-stage melanoma.

Visuals Work in Discouraging Indoor Tanning

May 02, 2017

A total of 568 undergraduate females were randomized to either 1 of 3 message conditions visually depicting health effects, appearance damage, or immediate risks, or to a text-only control.

Childhood Survivors May be Predisposed to Cancer Later in Life

April 05, 2017

More than one-quarter of patients who survived childhood cancer had developed another cancer by the age of 45.

Psoriasis May Up Melanoma, Hematologic Cancer Risk

March 28, 2017

The researchers found that patients with psoriasis had 1.53 times greater risk of developing a malignancy versus patients without psoriasis (P<0.01).

Bavencio Approved for Rare Skin Cancer

By March 23, 2017

The accelerated approval was based on data from a single-arm study (n=88) in patients with metastatic MCC who were treated with at least one prior chemotherapy regimen.

Massage Improves Pain, Lymphedema in Female CA Patients

March 10, 2017

The researchers found that all participants reported a positive experience with aromatherapy massage.

'Sizable Portion' of Melanoma Survivors Show Lax Attitude to UV Protection

March 03, 2017

A sizeable proportion of melanoma survivors still report elevated sun exposure, sunburns, and suboptimal ultraviolet radiation protection behaviors, according to research published online March 2 in Cancer Epidemiology, Biomarkers & Prevention.

Indoor Tanning Significant Contributor to Illness, Premature Death

March 01, 2017

Skin cancers from ultraviolet light in devices totaled 343.1 million in 2015 alone, researchers say

FDA Grants Opdivo Accelerated Approval For Urothelial Carcinoma

By February 03, 2017

The FDA has approved Opdivo (nivolumab; Bristol-Myers Squibb) for the treatment of patients with locally advanced or metastatic urothelial carcinoma who have disease progression during or after platinum-based chemotherapy or for those who have disease progression within 12 months of neoadjuvant or adjuvant platinum-based chemotherapy.

FDA: Multiple Pet Fatalities After Exposure to Human Topical Drug

By January 19, 2017

Clinicians and pharmacists who prescribe and fill medications containing the drug are advised to inform patients to avoid exposure to pets.

Has Earlier Melanoma Detection Affected Mortality Rates?

December 22, 2016

The burden of melanoma is increasing in the United States, according to a research letter published online in JAMA Dermatology.