Medications with Significant Anticholinergic Properties

Antihistamines

• chlorpheniramine, cyproheptadine, diphenhydramine, hydroxyzine

Blood pressure, increased

Breathing difficulty, changes

Clumsiness or unsteadiness

Convulsions

Digestive system changes, e.g.,

• Bloating

• Bowel motility, decreased

• Constipation

• Ileus, paralytic/adynamic

• Nausea or vomiting

• Swallowing difficulty with dry mouth

Mental status/behavior changes, e.g.,

• Distress, excitement, nervousness

• Attention, impaired

• Cognitive decline

• Confusion/disorientation

• Hallucinations

• Memory loss

• Restlessness or irritability

Delirium

Dizziness or Drowsiness

Fever

Headache

Heart rate, increased

Lethargy, fatigue

Mucous membrane dryness: mouth, nose 

Muscle weakness, severe

Speech, slurring

Skin, changes

• Dryness

• Sweating, decreased

• Flushing

• Warmth, excessive

Vision impairment, changes in acuity

• Blurring

• Glaucoma, worsening

• Eye pain

• Light sensitivity

Urinary retention or difficulty

Antidepressants

• amoxapine, amitriptyline, clomipramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, paroxetine

Antiemetics

• prochlorperazine, promethazine

Antipsychotics

• chlorpromazine, clozapine, olanzapine, thioridazine

Antivertigo

• meclizine, scopolamine

Cardiovascular

• furosemide, digoxin, nifedipine, disopyramide

Gastrointestinal

• Antidiarrheal: diphenoxylate atropine

• Antispasmodics: belladonna, clidinium, chlordiazepoxide, dicyclomine, hyoscyamine, propantheline

• Antiulcer: cimetidine, ranitidine

Muscle Relaxants

• cyclobenzaprine, dantrolene, orphenadrine

Parkinsonism

• amantadine, benztropine, biperiden, trihexyphenidyl

Urinary Incontinence

• oxybutynin, propantheline, solifenacin, tolterodine, trospium