Wi-Fi Drug Delivery: Implantable Devices Deliver Tx, Then Dissolve
the MPR take:
Researchers have developed a resorbable electronic implant that has been shown to eliminate bacterial infection in mice and then harmlessly dissolve. The study, published in the Proceedings of the National Academy of Sciences, describes the fully dissolvable wireless heating device consisting of a serpentine resistor and a power-receiving coil made of magnesium deposited onto a silk protein layer. The devices were implanted in vivo in S. aureus infected tissue in mice and activated by a wireless transmitter for two sets of 10 minute heat treatments. Twenty-four hours following the treatment, no sign of infection was detected in the tissue and the surrounding tissues were normal as well. After 15 days, the devices completely dissolved and magnesium levels at the implant site and surrounding areas were comparable to levels usually found in the body. While no studies have yet been conducted on humans, senior author Fiorenzo Omenetto notes that this could eventually lead to on-demand medical devices that are activated remotely and require no retrieval afterwards – a form of “wi-fi” drug delivery.
Researchers at Tufts University, in collaboration with a team at the University of Illinois at Champaign-Urbana, have demonstrated a resorbable electronic implant that eliminated bacterial infection in mice by delivering heat to infected tissue when triggered by a remote wireless signal.