Vitamin D Supplementation Not Recommended as Antihypertensive Tx
(HealthDay News) — Vitamin D supplementation is not associated with a reduction in blood pressure, according to a systematic review and meta-analysis published online March 16 in JAMA Internal Medicine.
Louise A. Beveridge, MB, ChB, from the University of Dundee in the United Kingdom, and colleagues conducted a systematic review to examine whether supplementation with vitamin D or vitamin D analogues reduced blood pressure. Data were included from 46 trials with 4,541 participants in a trial-level meta-analysis. Individual patient data were included for 3,092 participants in 27 trials.
The researchers found that vitamin D supplementation had no effect on systolic blood pressure (effect size, 0.0mmHg; P=0.97) or diastolic blood pressure (effect size, −0.1mmHg; P=0.84) at the trial level. Similar results were seen on analysis of individual patient data (systolic blood pressure: effect size, −0.5; P=0.27; diastolic blood pressure: effect size, 0.2; P=0.38). No baseline factor was found to predict a better response to therapy in subgroup analysis.
"Vitamin D supplementation is ineffective as an agent for lowering blood pressure and thus should not be used as an antihypertensive agent," the authors write.