Vitamin D May Affect In Vitro Fertilization Success Rate
(HealthDay News) — Vitamin D levels may affect the pregnancy rate in women undergoing in vitro fertilization (IVF), according to research published online August 14 in the Journal of Clinical Endocrinology & Metabolism.
Alessio Paffoni, of the Ospedale Maggiore Policlinico in Milan, and colleagues conducted a prospective cross-sectional study to assess IVF outcomes in women (aged 18–42 years) according to serum level of 25-hydroxyvitamin D (25[OH]D).
The researchers found that, among women with vitamin D deficiency (<20ng/mL), the clinical pregnancy rate following IVF was 20% (30 of 154 patients). Among women with serum 25(OH)D levels of ≥20ng/mL, the clinical pregnancy rate following IVF was 31% (56 of 181 patients), and the adjusted odds ratio was 2.15. According to subgroup analysis, women with the highest serum levels of vitamin D were most likely to become pregnant after undergoing IVF.
"Vitamin D is an emerging factor influencing female fertility and IVF outcome," the authors write. "Additional studies are pressingly needed to confirm a causal relationship and to investigate the potential therapeutic benefits of vitamin D supplementation."