Vitamin D Deficiency Ups Asthma Exacerbation Odds
Ronit Confino-Cohen, MD, from the Meir Medical Center in Kfar Saba, Israel, and colleagues examined the correlations between serum 25-hydroxyvitamin D (25[OH]D) level and asthma in a cohort of Israeli adults aged 22–50 years. Participants with physician-diagnosed asthma and asthma exacerbation were identified.
The researchers found that 6.9% of the 308,000 participants with at least one vitamin D measurement had physician-diagnosed asthma, compared with 5.7% in the general population. Serum 25(OH)D levels were similar for those with and without asthma. The odds of having an exacerbation were 25% greater for those with vitamin D deficiency than for those with vitamin D levels in the normal range. This significant correlation persisted even after adjustment for confounding variables.
"The presented evidence supports vitamin D screening in the subgroup of asthmatics that are uncontrolled and experience recurrent exacerbations," the authors write.