Upfront Laryngectomy May Improve Advanced-Stage Laryngeal CA Outcomes
(HealthDay News) — Patients with advanced-stage laryngeal cancer treated at Louisiana State University Health-Shreveport (LSU Health) have higher survival rates, according to a study published online November 27 in JAMA Otolaryngology-Head & Neck Surgery.
Blake Joseph LeBlanc, MD, from LSU Health, and colleagues compared survival outcomes for initial surgical treatment of advanced-stage primary tumors. The authors identified patients diagnosed as having laryngeal carcinoma between 1998–2007. Data for 165 patients treated at LSU Health and national data were obtained from the National Cancer Database.
The researchers found that 70.9% of patients presented with advanced-stage (III/IV) disease at LSU Health, compared with 46.67% nationwide (P<0.05). More LSU Heath patients were uninsured (23.73 vs. 5.05% nationally; P<0.001), and more patients traveled further distances for care (60.74% traveling ≥50 miles vs. 15.87% nationally; P<0.001). Overall, 54.70% of patients with advanced-stage disease underwent primary surgery to include total laryngectomy; the rate of laryngectomy decreased from 40 to 60% in the 1980s to 32% in 2007.
"We believe that upfront laryngectomy may explain our higher survival rates for advanced-stage laryngeal cancer," the authors write.