Tracking Estrogen-Progestin Use Over the Past 40 Years

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Tracking Estrogen-Progestin Use Over the Past 40 Years
Tracking Estrogen-Progestin Use Over the Past 40 Years

(HealthDay News) — The use of estrogen-progestin has varied over the past 40 years, peaking in the 1990s and declining in the early 2000s, according to a study published online September 8 in Obstetrics & Gynecology.

Patricia I. Jewett, from the University of Wisconsin-Madison, and colleagues integrated data on oral estrogen-progestin use from the National Health and Nutrition Examination Survey (1999–2010) with data from the National Prescription Audit (1970–2003). Long-term trends in estrogen-progestin prevalence were estimated for 1970–2010.

The researchers found that the estimated prevalence of oral estrogen-progestin was below 0.5% in the 1970s and began to rise in the early 1980s. Between 1990 and the late 1990s the estimated prevalence almost tripled. For women aged 45–64 years, the age-adjusted prevalence peaked at 13.5% in 1999, with highest use among women aged 57 years (23.3%). In the early 2000s, the prevalence of estrogen-progestin use declined dramatically, with use estimated at 2.7% for women aged 45–64 years in 2010, comparable to prevalence in the mid-1980s.

"The dramatic rise and fall of estrogen-progestin use over the past 40 years provides an illuminating case study of prescription practices before, during, and after the development of evidence regarding benefits and harms," the authors write.

Abstract
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