The Effect of Immunosuppressants on Hepatitis E Viral Replication
the MPR take:
In a study published in the journal Gastroenterology, the effects of different immunosuppressants on hepatitis E viral (HEV) replication were evaluated to determine which drugs promote or inhibit the virus. After analyzing the drugs, the following was discovered:
- Steroids had no effect on HEV replication
- Cyclosporin A promoted HEV replication
- High-dose tacrolimus promoted liver cell infection with HEV
- Mycophenolic acid (MPA) inhibited HEV replication
- MPA + ribavirin inhibited HEV replication better than either drug alone
Researchers conclude that physicians should take these findings into consideration when selecting immunosuppressive drugs for organ transplant recipients with HEV infection.
Many recipients of organ transplants develop chronic hepatitis, due to infection with the hepatitis E virus (HEV). Publishing in Gastroenterology, Yijin Wang and colleagues find that cyclophilins A and B inhibit replication of HEV; this might explain the ability of cyclosporin A to promote HEV infection.
READ FULL ARTICLE From Gastro