Sumatriptan Route of Administration Plays a Role in Migraine Relief

the MPR take:

A study of the four different routes of administration of sumatriptan shows that the way the drug is given can impact how quickly and effectively a patient will receive migraine relief.  In this review the subcutaneous (SC) injection of sumatriptan was found to be the most effective route of administration, providing more rapid relief of pain compared to the oral, intranasal, and rectal routes. The most effective headache relief was seen with the following doses of sumatriptan: oral (100mg), SC inj (6mg), intranasal (20mg), and rectal (25mg). Adverse events, while mild, were seen mostly with the SC inj formulation as well as high doses of oral and intranasal preparations.

Sumatriptan (all routes of administration) for acute migraine attacks in adults overview of Cochrane
Sumatriptan (all routes of administration) for acute migraine attacks in adults overview of Cochrane

Sumatriptan is an abortive medication for migraine attacks, belonging to the triptan family. From each individual review we extracted results for pain relief at different levels, and adverse events. We focused on the most important findings for doses and routes licensed in North America or Europe (oral 25 mg, 50 mg, 100 mg; subcutaneous 4 mg, 6 mg; intranasal 5 mg, 10 mg, 20 mg; rectal 25 mg).

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