Study: Modafinil for Cancer-Related Fatigue

the MPR take:

Study results published in the Journal of Clinical Oncology show that modafinil, a CNS stimulant drug often used to treat cancer-related fatigue, had no effect on patients with non-small cell lung cancer in managing their fatigue.  In the study, patients were randomized to receive either modafinil or placebo; 160 patients were included in the analysis. At day 28 of the study, no differences were seen between placebo and modafinil with regards to improving fatigue scores. Researchers conclude that this treatment should not be prescribed to patients for managing cancer-related fatigue.

Modafinil for the Treatment of Fatigue in Lung Cancer: Results of a Placebo-Controlled, Double-Blind
Modafinil for the Treatment of Fatigue in Lung Cancer: Results of a Placebo-Controlled, Double-Blind

Purpose: Fatigue is a distressing symptom occurring in more than 60% of patients with cancer. The CNS stimulants modafinil and methylphenidate are recommended for the treatment of cancer-related fatigue, despite a limited evidence base. Patients and Methods Adults with advanced NSCLC and ...

READ FULL ARTICLE From Ascopubs