Some RA Drugs May Reduce Vaccine Effectiveness
the MPR take:
A new review published in Arthritis Care & Research has found that humoral response to pneumococcal and influenza vaccines could be decreased in patients with rheumatoid arthritis (RA) taking methotrexate and/or biologic agents. In the evaluation of 12 studies, the RA patients primarily received methotrexate, anti–tumor necrosis factor α (anti-TNFα), or rituximab (Rituxan: Genetech). Response to influenza vaccination for H1N1 and H3N3 was reduced in patients taking rituximab and varied in the methotrexate group. With pneumococcal vaccination, response was reduced for both rituximab and methotrexate patients. No reduction was seen in patients taking anti-TNFα compared to the control group for any of the vaccines.
Objective: To assess the current literature on the impact of rheumatoid arthritis (RA) treatments on the humoral response to pneumococcal and influenza vaccines. Influenza vaccination response was reduced for RTX (43 patients; pooled odds ratio [OR] 0.44 [95% confidence interval (95% CI) 0.17 1.12] for H1N1, OR 0.11 [95% CI 0.04 0.31] for H3N2, and OR 0.29 [95% CI 0.10 0.81] for B) but not for anti-TNF.
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