Sleep-Disordered Breathing in REM Linked to Insulin Resistance
(HealthDay News) — The correlation between sleep-disordered breathing (SDB) and glucose metabolism varies for rapid eye movement (REM) sleep and non-REM sleep, according to a study published in the Nov. 1 issue of the American Journal of Respiratory and Critical Care Medicine.
Hassan A. Chami, M.D., from the American University of Beirut, and colleagues characterized the association between REM-related SDB, glucose intolerance, and insulin resistance in a community-based sample of 3,310 participants. The apnea-hypopnea index (AHI) was used to quantify SDB severity during REM (AHIREM) and non-REM (AHINREM) sleep. A glucose tolerance test assessed fasting and two-hour post-challenge glucose levels in 2,264 participants; the homeostatic model assessment index for insulin resistance (HOMA-IR) was measured for 1,543 participants.
The researchers found that in models that adjusted for age, sex, race, and site, AHIREM and AHINREM correlated with fasting glycemia, postprandial glucose levels, and HOMA-IR. AHIREM was only associated with HOMA-IR and AHINREM was only associated with fasting and postprandial glucose levels after further adjustment for body mass index, waist circumference, and sleep duration.
"AHIREM is associated with insulin resistance but not with fasting glycemia or glucose intolerance," the authors write.