Short, Poor Quality Sleep Tied to Increased β-Amyloid Burden

Short, Poor Quality Sleep Tied to Increased &#946-Amyloid Burden
Short, Poor Quality Sleep Tied to Increased β-Amyloid Burden

(HealthDay News) – In older adults, shorter sleep duration and poor sleep quality are associated with increased β-amyloid (Aβ) deposition, according to a study published online Oct. 21 in JAMA Neurology.

Adam P. Spira, PhD, from the Johns Hopkins Bloomberg School of Public Health in Baltimore, and colleagues conducted a cross-sectional study involving 70 adults (mean age, 76 years) from a normative aging study to examine the correlation between self-reported sleep variables and Aβ deposition.

The researchers found that reports of shorter sleep duration correlated with greater Aβ burden, after adjustment for potential confounding variables, as measured by mean cortical and precuneus carbon 11-labeled Pittsburg compound B positron emission tomography distribution volume ratios (DVRs). There was also a correlation between reports of lower sleep quality with increased Aβ burden, measured by precuneus DVR.

"As evidence of this association accumulates, intervention trials will be needed to determine whether optimizing sleep can prevent or slow Alzheimer's disease progression," the authors write.

One author disclosed financial ties to Avid (via his institution).

Abstract
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