Serum Biomarkers Identify Early Pancreatic Cancers
(HealthDay News) – The DNA of two genes is frequently altered in patients with early-stage pancreatic cancer, modifications that can be accurately detected in cancer cells and serum, according to a study published online Oct. 2 in Clinical Cancer Research.
Joo Mi Yi, PhD, from the Dongnam Institute of Radiological and Medical Sciences in Busan, South Korea, and colleagues performed a genome-wide pharmacologic transcriptome analysis to identify cancer-specific alterations in DNA methylation in pancreatic cancers.
The researchers found that the BNC1 and ADAMTS1 genes were frequently methylated in 143 pancreatic cancers, with a frequency up to 100% for pancreatic intraepithelial neoplasia and 97% for stage I invasive cancers. These alterations could also be detected in serum from 42 patients with pancreatic cancer using nanoparticle-enabled methylation-on-beads technology. Using both markers, the overall sensitivity was 81% and overall specificity was 85% for serum testing.
"Promoter DNA methylation of BNC1 and ADAMTS1 are potential biomarkers to detect early-stage pancreatic cancers," Yi and colleagues conclude.