Screening With Fasting Glycemia can be an Alternative to 75-g GTT for GDM

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Screening with fasting glycemia results in sensitivity of 78.5%, avoids glucose loading
Screening with fasting glycemia results in sensitivity of 78.5%, avoids glucose loading

HealthDay News — Screening for gestational diabetes with fasting glycemia seems to be an acceptable alternative to universal screening with the complete 75-gram glucose tolerance test, according to a study published online January 25 in BJOG: An International Journal of Obstetrics & Gynaecology.

J. Ryser Rüetschi, from the University Hospitals of Geneva, and colleagues collected 2,298 complete 75-g glucose tolerance tests from pregnant women at 24 to 28 weeks of gestation. They simulated stopping the test if fasting glycemia was <4.4 or ≥5.1 mmol/L, thereby avoiding glucose loading and further glycemia.

The researchers found that within the population, the prevalence of gestational diabetes was 10.9%. Among 251 women with gestational diabetes, fasting glycemia was ≥5.1, between 4.4 and <5.1, and <4.4 mmol/L in 47.4, 31.1, and 21.5%, respectively. The sensitivity was 78.5% with performance of the complete test only in women with fasting glycemia between 4.4 and <5.1 mmol/L; this would avert glucose loading in 63.8% of women.

"Screening with fasting glycemia is an attractive alternative to universal screening with the complete 75-g glucose tolerance test," the authors write. "This strategy is, however, slightly less sensitive than previously reported in higher-risk populations."

Abstract
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