Salicylates Reduce Metabolic Clearance of Insulin
(HealthDay News) — Salsalate increases insulin concentrations by decreasing metabolic clearance of insulin (MCI), not by increasing insulin secretion, according to research published online Feb. 13 in Diabetes, Obesity and Metabolism.
Adela Penesova, M.D., Ph.D., of the Slovak Academy of Sciences in Bratislava, Slovakia, and colleagues conducted a substudy in 27 obese individuals without diabetes who were enrolled in a randomized, double-blind, parallel, placebo-controlled clinical trial. Participants were randomly assigned to receive salsalate (16 individuals) or placebo (11 individuals). Baseline and follow-up stepped glucose infusion (SGI) was performed, and the effect of salsalate on insulin was examined.
The researchers found that during SGI in the salsalate group, C-peptide concentrations decreased by 11 percent, and plasma insulin concentrations increased by 30 percent; this corresponded to a 30 percent reduction in MCI (P < 0.0001). At molar increments of glucose, insulin concentrations were increased by 27 percent (P = 0.02), but insulin secretion rate remained unchanged.
"In conclusion, salsalate did not alter insulin secretion, but lowered MCI, indicating that reduction in insulin clearance is a principal mechanism for increased insulin levels after salicylates administration," the authors write.