Remission of T2DM Without Bariatric Surgery Rare But Possible
Andrew J. Karter, PhD, from Kaiser Permanente Northern California in Oakland, and colleagues examined the incidence and correlates of diabetes remission in a cohort of 122,781 adults with type 2 diabetes not treated with bariatric surgery. Remission required the absence of ongoing drug treatment and was defined as partial (at least one year of subdiabetic hyperglycemia); complete (at least one year of normoglycemia); and prolonged (complete remission for at least five years).
The researchers found that the incidence density of partial, complete, or prolonged remission was 2.8, 0.24, and 0.04 remissions per 1,000 person-years, respectively. The seven-year cumulative incidence of partial remission was 1.47%, complete remission was 0.14%, and prolonged remission was 0.007%. In the whole cohort and the subgroup with new onset diabetes (less than two years since diagnosis), the seven-year cumulative incidence of achieving any remission was 1.60 and 4.6%, respectively. Correlates of remission included age >65 years, African-American race, less than two years since diagnosis, baseline hemoglobin A1c level <5.7%, and no diabetes medications at baseline, after adjustment for demographic and clinical characteristics.
"In community settings, remission of type 2 diabetes does occur without bariatric surgery, but it is very rare," the authors write.