Phentermine, Topiramate Reduce Progression to T2DM

Phentermine, Topiramate Reduce Progression to T2DM
Phentermine, Topiramate Reduce Progression to T2DM

(HealthDay News) – Over two years, phentermine and topiramate extended-release (PHEN/TPM ER) treatment plus lifestyle changes lead to significant weight loss and a considerable reduction in progression to type 2 diabetes in high-risk, overweight/obese individuals, according to a study published online Oct. 8 in Diabetes Care.

W. Timothy Garvey, MD, from the University of Alabama at Birmingham, and colleagues conducted subanalysis of a phase 3, randomized, double-blind study of overweight/obese subjects (BMI ≥27 to ≤45kg/m²) with two or more comorbidities. Participants were randomized to receive placebo, PHEN 7.5mg/TPM ER 46mg (7.5/46), or PHEN 15mg/TPM ER 92mg (15/92) plus lifestyle modifications for 108 weeks.

The researchers found that, at baseline, 475 participants had prediabetes and/or metabolic syndrome (MetS). The mean percent weight loss for these participants was 2.5%, 10.9%, and 12.1%, respectively, in the placebo, 7.5/46, and 15/92 groups after 108 weeks. Compared with placebo, there were reductions of 70.5% and 78.7% in the annualized incidence rate of type 2 diabetes for the 7.5/46 and 15/92 groups, respectively. The reductions correlated with the degree of weight loss and were accompanied by significant cardiometabolic parameter improvements. Over two years, PHEN/TPM ER was well tolerated.

"PHEN/TPM ER plus lifestyle modification produced significant weight loss and markedly reduced progression to type 2 diabetes in overweight/obese patients with prediabetes and/or MetS," the authors conclude.

Several authors disclosed financial ties to pharmaceutical companies, including VIVUS, which funded the study and manufactures PHEN/TPM ER.

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