PCOS, IVF Outcomes Vary With BMI
(HealthDay News) — For women with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization (IVF), body mass index (BMI) impacts outcomes, according to a study published in the August issue of the American Journal of Obstetrics & Gynecology.
Amelia P. Bailey, MD, from Brigham and Women's Hospital and Harvard Medical School in Boston, and colleagues conducted a retrospective cohort study to examine the effect of BMI on IVF outcomes. Data were included from 101 cycles from 79 women aged <40 years with a clinically documented diagnosis of PCOS.
The researchers found that compared with lean women with PCOS, obese women with PCOS had significantly lower odds of clinical pregnancy per cycle (odds ratio [OR], 0.31; 95% confidence interval [CI], 0.11–0.86; P=0.02) and of clinical pregnancy per embryo transfer (OR, 0.23; 95% CI, −0.08–0.68; P=0.008). The odds of live birth were significantly lower per cycle start (OR, 0.29; P=0.02) and per embryo transfer (OR, 0.23; P=0.01) for obese vs. lean women with PCOS. Among women with PCOS, increasing BMI correlated with a trend toward decreasing ovarian hyperstimulation syndrome incidence (19.6, 10.5, and 3.2% in lean, overweight, and obese women, respectively).
"PCOS is a broad syndrome, with our results demonstrating two distinct populations, lean and obese, which have different IVF outcomes including ovarian hyperstimulation syndrome risk profiles," the authors write.