Parkinson's Disease: Drug Treatment Review
the MPR take:
A review of the pharmacological management of Parkinson's disease in The Journal of the American Medical Association supports the use of levodopa and dopamine agonists to treat the motor symptoms of the disease at all stages. For motor fluctuations, dopamine agonists or agents that block dopamine metabolism work well. Other symptomatic therapies include clozapine for the treatment of hallucinations, cholinesterase inhibitors for dementia symptoms, and pramipexole and antidepressants for improving depression. Therapies outside of this evidence-based review are less well established.
Objective: To provide an evidence-based review of the initial pharmacological management of the classic motor symptoms of Parkinson disease; describe management of medication-related motor complications (such as motor fluctuations and dyskinesia), and other medication adverse effects (nausea, ...
READ FULL ARTICLE From jama.jamanetwork.com