Parkinsonism, ADHD: Common Genetic Link?
the MPR take:
A genetic mutation that disrupts dopaminergic signaling has been linked to attention deficit hyperactivity disorder (ADHD) and may also cause parkinsonism in young people. A case study published in The Journal of Clinical Investigation used dopamine transporter (DAT) single-photon emission computed tomography (DAT-SPECT) scans and a fluoro-deoxy-glucose-PET/MRI (FDG-PET/MRI) scan on an adult male with early-onset parkinsonism and ADHD. The scans revealed that the patient suffered from progressive dopaminergic neurodegeneration and DNA analysis noted two SLC6A3 genetic mutations (DAT-I312F and DAT-D421N). This study is believed to be the first to link DAT missense mutations and early-onset parkinsonism in adults and possibly other brain and psychiatric conditions like ADHD.
(University of Copenhagen - The Faculty of Health and Medical Sciences) Researchers at the University of Copenhagen and the Copenhagen University Hospital have identified a particular genetic mutation that may cause parkinsonism in young people. The mutation interferes with the brain's transport of the important signal substance dopamine and may also plays a role in mental diseases...
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