Obesity, T2D-Related Enzyme Targeted in Study
the MPR take:
The enzyme nicotinamide N-methyltransferase (NNMT), located in the fat and liver of mice, could help cells in burning energy efficiently by modifying the gene that produces the enzyme. As reported in the April 10th issue of Nature, significant amounts of NNMT were found in the fat of mice predisposed to obesity or diabetes. These mice stored the NNMT in body fat, rather than using glucose efficiently, so researchers administered a targeted genetic medication to impact the gene and reduce levels of the enzyme in the fat and liver. This reduced body fat by 47% and increased lean body mass by 15%. A 50–60% reduction in blood insulin levels was also seen, indicating improved insulin sensitivity.
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