NSAIDs Up Odds of Anastomotic Leak Post-Colorectal Resection

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NSAIDs, Anastomotic Leak
NSAIDs, Anastomotic Leak

(HealthDay News) — For patients undergoing nonelective colorectal resection, postoperative nonsteroidal anti-inflammatory drug (NSAID) administration is associated with increased odds of anastomotic leaks, according to a study published online January 21 in JAMA Surgery.

Timo W. Hakkarainen, MD, from the University of Washington Medical Center in Seattle, and colleagues examined the correlation between postoperative NSAID administration and anastomotic complications. Data were included from a retrospective cohort of 13,082 patients undergoing bariatric or colorectal surgery at 47 hospitals from 2006–2010; 24.1% received NSAIDs beginning within 24 hours after surgery.

The researchers found that the overall 90-day rate of anastomotic leaks was 4.3% for all patients (4.8 and 4.2% in the NSAID and non-NSAID group, respectively; P=0.16). NSAIDs correlated with an increased risk of anastomotic leak after risk adjustment (odds ratio, 1.24; P=0.04). This correlation was specific to nonelective colorectal surgery, with a leak rate of 12.3% in the NSAID group vs. 8.3% in the non-NSAID group (odds ratio, 1.70; P=0.01).

"To determine the role of NSAIDs in colorectal surgery, future evaluations should consider specific formulations, the dose effect, mechanism, and other relevant outcome domains, including pain control, cardiac complications, and overall recovery," the authors write.

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