No Cardiac Defect Risk with Antidepressant Use During Pregnancy
the MPR take:
A study in the New England Journal of Medicine reports that use of SSRIs and other antidepressants during pregnancy does not significantly increase the risk of congenital heart defects. Data on 64,389 women from 2000–2007 who were taking antidepressants during the first trimester of their pregnancy was assessed; the researchers found no significant association between the use of paroxetine and right ventricular outflow tract obstruction or between the use of sertraline and ventricular septal defects after adjusting for potential confounding factors such as age, comorbidity, and psychotropic medication use.
That should reassure the 8% to 13% of women who take antidepressants while expecting. Concerns about the risks of the drugs, primarily selective serotonin reuptake inhibitors (SSRIs), on the developing fetus prompted the Food and Drug Administration in 2005 to add warnings about the risk of heart defects in babies born to moms taking antidepressants.
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