Neuron Hyperactivity May Cause Depression
the MPR take:
An area of the brain associated with the regulation of emotions and behavior may be a cause of depression under stress, according to research published in the Journal of Neuroscience. Researchers examined the medial prefrontal cortex (mPFC), which is linked to emotions and behavior, and activated stress in mice to evaluate the changes in mPFC neurons. These neurons became activated in mice that were exhibiting signs of depression from the stress, but were weak in those who were not. After the once-resilient mice were engineered with neurological conditions associated with depression, the mPFC neurons too became activated. Treatments such as deep brain stimulation (DBS) and transcranial magnet stimulation (TMS) target these neurons and have shown to be successful in clinical trials.
A team of scientists looked to mice to find biological answers for these different responses and found the reason my lie deep in the brain. Researchers have long wanted to know whether hyperactivity in mPFC causes depression or if the activity in that part of the brain is a result of something else (and thus not the cause of depression).
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