More Vegetables Could Reduce Hepatocellular Carcinoma Risk
(HealthDay News) — Increased intake of vegetables, but not fruit, is associated with a reduction in the risk of hepatocellular carcinoma (HCC), according to research published in the November issue of Gastroenterology.
Yang Yang, from the Zhejiang Cancer Hospital in Hangzhou, China, and colleagues performed a meta-analysis of observational studies to quantify the correlation between vegetable and fruit consumption and risk of HCC. The authors included 19 studies involving 1,290,045 participants and 3,912 cases of HCC.
The researchers found that for individuals with high vs. low intake of vegetables, the summary relative risk for HCC was 0.72 (95% confidence interval [CI], 0.63–0.83). A 100g/day daily increase in vegetable intake correlated with a summary relative risk of 0.92 for HCC (95% CI, 0.88–0.95). The association persisted irrespective of history of hepatitis, alcohol drinking, smoking, or energy intake. For high vs. low intake of fruit, the summary relative risk for HCC was 0.93 (95% CI, 0.80–1.09); for a 100g/day daily increase in fruit intake, the summary relative risk was 0.99 (95% CI, 0.94–1.05).
"Based on a meta-analysis, increased intake of vegetables, but not fruit, is associated with lower risk for HCC," the authors write. "The findings should be confirmed by future studies with validated questionnaires and strict control of confounders."