MiRNA Expression Reprograms Fibroblasts in Ovarian Cancer

This article originally appeared here.
MiRNA Expression Reprograms Fibroblasts in Ovarian Cancer
MiRNA Expression Reprograms Fibroblasts in Ovarian Cancer

(HealthDay News) – Fibroblasts present in the stroma of ovarian cancer cells can be programmed to become cancer-associated fibroblasts by changing the expression pattern of three microRNAs (miRNAs), according to a study published online Nov. 21 in Cancer Discovery.

Anirban K. Mitra, PhD, from the University of Chicago, and colleagues compared miRNA expression in cancer-associated fibroblasts from patients with ovarian cancer and normal or tumor-adjacent fibroblasts.

The researchers found that two miRNAs were downregulated (miR-31 and miR-214) and one was upregulated (miR-155) in cancer-associated fibroblasts. Replicating this pattern of expression in normal fibroblasts converted them into cancer-associated fibroblasts, while correcting this expression pattern in cancer-associated fibroblasts converted them into normal fibroblasts. Cancer-associated fibroblasts had increased expression of chemokines known to be important for their function, particularly the chemokine C-C motif ligand 5, which was a direct target of miR-214.

"These results indicate that ovarian cancer cells reprogram fibroblasts to become cancer-associated fibroblasts though the action of miRNAs," Mitra and colleagues conclude. "Targeting these miRNAs in stromal cells could have therapeutic benefit."

Abstract
Full Text (subscription or payment may be required)