Why Patients With Metabolic Syndrome May Need More Vitamin E
(HealthDay News) — For adults, α-tocopheraol bioavailability is unaffected by dairy fat quantity but is lower in those with metabolic syndrome (MetS), according to a study published online October 7 in The American Journal of Clinical Nutrition.
Eunice Mah, PhD, from Ohio State University in Columbus, and colleagues examined dose-dependent effects of dairy fat and MetS health status on α-tocopherol pharmacokinetics in plasma and lipoproteins in a randomized crossover study. Ten healthy adults and 10 with MetS ingested encapsulated hexadeuterium-labeled (d6)-RRR-α-tocopherol with 240mL nonfat (0.2g fat), reduced-fat (4.8g fat), or whole (7.9g fat) milk. Blood was drawn at regular intervals during 72 hours.
The researchers found that participants with MetS had lower baseline plasma α-tocopherol and greater oxidized low-density lipoprotein, interleukin (IL)-6, IL-10, and C-reactive protein (P<0.05) compared with healthy participants. Increasing amounts of dairy fat provided by milk beverages had no impact on d6-α-tocopherol bioavailability, regardless of health status. Compared with healthy participants, MetS participants had lower estimated d6-α-tocopherol absorption. In addition, they had lower plasma d6-α-tocopherol area under the curve from zero to 72 hours, lower maximal concentrations, and slower rates of plasma disappearance.
"These findings support higher dietary α-tocopherol requirements for MetS adults," the authors write.